Oncology Clinical Trials in Charleston, SC
As of August 2026, 103 paid clinical trials are recruiting for Oncology in Charleston, South Carolina. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Charleston
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Study of Autologous, Metabolically Optimized, CD137+ Tumor-Infiltrating Lymphocytes Followed by Consolidative Oral Cyclophosphamide, Bevacizumab, and Pembrolizumab
105 clinical trials for Oncology
·Clear filters·A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer
A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer
Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)
Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)
A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies
A Phase 3 Single-arm Study of UGN-104 for the Treatment of Low-grade Upper Tract Urothelial Cancer
A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)
GEMINI-NSCLC: NSCLC Biomarker Study
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
Caris Biorepository Research Protocol
A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma
A First-in-human Study of PARP1 Selective Inhibitor, IMP1734, in Participants With Advanced Solid Tumors
DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors
uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto
Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier
Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced Solid Tumors
Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
Top Research Study Locations in Charleston
Researchers run research studies in Charleston, SC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Medical University of South Carolina | Depression, Heart Failure, Parkinson Disease | 378 |
| Medical University of South Carolina (MUSC) | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 26 |
| Ralph H. Johnson VA Medical Center, Charleston, SC | Stroke, Depression, PTSD | 22 |
| Ralph H Johnson VA Medical Center | Stage IV Lung Cancer AJCC v8, Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum | 11 |
| Medical University of South Carolina Hollings Cancer Center | Brain Metastases, Cancer (With CNS Involvement), Locally Advanced Pancreatic Adenocarcinoma | 7 |
| Ralph H. Johnson VA Health Care System | Adjustment Disorders, Agitation, Alzheimer Disease | 7 |
| MUSC | Cardiovascular Diseases, Focal Epilepsy, Heart Failure | 6 |
| MUSC Hollings Cancer Center | Advanced Renal Cell Carcinoma (RCC), Advanced Solid Tumor, Cachexia | 6 |
| Hollings Cancer Center | Acute Myeloid Leukemia, Breast Cancer, Chronic Myelomonocytic Leukemia | 5 |
| GSK Investigational Site | Asthma, Chickenpox, Hypereosinophilic Syndrome | 4 |
| Hollings Cancer Center at Medical University of South Carolina | B-cell Non Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Locally Advanced Pancreatic Adenocarcinoma | 4 |
| Medical University of South Carolina University Hospital | Intracerebral Hemorrhage, Ischemic Stroke, Atrial Fibrillation | 4 |
| Bon Secours Saint Francis Hospital | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, HER2-Negative Breast Carcinoma | 3 |
| Lowcountry Lung and Critical Care, PA | Idiopathic Hypersomnia, Idiopathic Pulmonary Fibrosis (IPF), OSA | 3 |
| Medical University South Carolina | Knee Arthroplasty, Total, Lower Respiratory Tract Infection, Myasthenia Gravis | 3 |
| Medical University of South Carolina Children's Hospital | Focal Segmental Glomerulosclerosis, Rheumatic Joint Disease | 3 |
| University of South Carolina | Alpha1-Antitrypsin Deficiency, Growth Hormone Deficiency, Lupus Nephritis | 3 |
| Charleston Neuroscience Institute | NAION( Non-arteritic Anterior Ischemic Optic Neuropathy), Neovascular Age-related Macular Degeneration, Open Angle Glaucoma (OAG) | 3 |
| 30 Bee Street | Depression, Post Stroke Pain | 2 |
| 89bio Clinical Study Site | Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis | 2 |
| Akero Clinical Study Site | MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, NASH - Nonalcoholic Steatohepatitis | 2 |
| Charleston Neuroscience Institute, LLC (Charleston) | Macular Edema Secondary to Inflammation | 2 |
| Charleston VA Healthcare System | Chronic Pain, Post Traumatic Stress Disorder, Post Traumatic Stress Disorder (PTSD) | 2 |
| Charleston VA Medical Center | Cardiovascular Diseases, Cognitive Impairment, Mild, Dementia | 2 |
| Clinical Research Center of the Carolinas | Cutaneous Squamous Cell Carcinoma (CSCC), Moderate to Severe Glabellar Lines | 2 |
Active & Upcoming Studies in Charleston (2026)
Recruiting trials in Charleston grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (161 active studies)
- Study of Autologous, Metabolically Optimized, CD137+ Tumor-Infiltrating Lymphocytes Followed by Consolidative Oral Cyclophosphamide, Bevacizumab, and Pembrolizumab · Phase 2 · Medical University of South Carolina
- Cemiplimab for Clinical Stage I, 2-3.9cm, Non-Small Cell Lung Cancer · Phase 2 · Medical University of South Carolina
Mental health & behavior (59 active studies)
- PTSD and Alcohol Couples Treatment for Veterans · EARLY_Phase 1 · VA Office of Research and Development
- Treatment of Depression Post-SCI · Medical University of South Carolina
Neurology & pain (58 active studies)
- Prescriptive Infusion Algorithm (PIA) · Phase 2 · AskBio Inc
- Accelerated rTMS for Apathy in Parkinson's Disease · Medical University of South Carolina
Cardiovascular (53 active studies)
Diabetes & metabolic (15 active studies)
- A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide · Phase 3 · Novo Nordisk A/S
- Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients · Phase 1 · Medical University of South Carolina
Eye & vision (11 active studies)
- A Study to Evaluate the Efficacy and Safety of Tabirafusp Tedromer Compared to Aflibercept in Participants With DME - ALTO · Phase 3 · Kodiak Sciences Inc
- A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration · Phase 3 · Amgen
Pediatric (11 active studies)
- The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma · Phase 2 · Wake Forest University Health Sciences
- A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study · Carelon Research
Vaccines (5 active studies)
- A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of Age · Phase 3 · GlaxoSmithKline
- A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised · Phase 3 · Pfizer
HIV / STI (3 active studies)
- Engaging Pharmacists to Advance Tobacco Treatment Service Delivery · Medical University of South Carolina
- Development and Evaluation of a Virtual Reality Tool for At-Risk Trauma-Exposed Young People · Medical University of South Carolina
Common conditions studied in Charleston
- Stroke (14 active studies)
- Depression (13 active studies)
- Heart Failure (13 active studies)
- Acute Myeloid Leukemia (8 active studies)
- Cardiovascular Diseases (8 active studies)
- Obesity (8 active studies)
Leading research sponsors in Charleston
- Medical University of South Carolina
- National Cancer Institute (NCI)
- VA Office of Research and Development
- AstraZeneca
- NRG Oncology
Frequently asked questions
How many paid clinical trials are currently recruiting in Charleston?
There are approximately 682 recruiting clinical trials in Charleston, South Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Charleston pay participants?
Most recruiting trials in Charleston compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Charleston?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Charleston?
The most common conditions under active study in Charleston include Stroke (14), Depression (13), Heart Failure (13), Acute Myeloid Leukemia (8), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Charleston?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Charleston on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Charleston?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Charleston?
Recruiting research sites in Charleston include Medical University of South Carolina, Medical University of South Carolina (MUSC), Ralph H. Johnson VA Medical Center, Charleston, SC, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Charleston right now?
The largest active categories in Charleston are Cancer & tumors (161), Mental health & behavior (59), Neurology & pain (58). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.