Behavioral health Clinical Trials in Chicago, IL

As of July 2026, 73 paid clinical trials are recruiting for Behavioral health in Chicago, Illinois. Behavioral health trials span mental-health pharmacotherapy and addiction treatment — testing new agents and therapies for depression, anxiety, opioid use disorder, alcohol use, and tobacco cessation. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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78 clinical trials for Behavioral health

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Evaluating The Efficacy Of Combined Cognitive Processing Therapy and Stellate Ganglion Blocks for PTSD

for PTSD

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT06570213·EARLY_Phase 1·Recruiting·Listed Aug 2024

Apply to this trial

My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life

for Cancer

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05369429·Recruiting·Listed May 2022

Apply to this trial

Test of Target Engagement of Ambiguity Aversion

for Intolerance of Uncertainty

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 25 - 60·Accepts healthy volunteers

Code: NCT06962527·Recruiting·Listed May 2025

Apply to this trial

Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSD

for Posttraumatic Headache

Sites in Chicago +2 more locations

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06608277·Phase 2·Recruiting·Listed Sep 2024

Apply to this trial

Neuromodulation and Neurorehabilitation for mTBI

for Mild Traumatic Brain Injury

Sites in Chicago +1 more location

Sponsor: Northwestern University

Sex: All·Age: 18 - 80

Code: NCT03819608·Recruiting·Listed Jan 2019

Apply to this trial

Scalable TELeheaLth Cancer CARe: The STELLAR Program to Treat Cancer Risk Behaviors

for Obesity

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05687604·Recruiting·Listed Jan 2023

Apply to this trial

StuDy AimED at Increasing AlCohol AbsTinEnce

for Alcohol Use Disorder

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 24·Accepts healthy volunteers

Code: NCT05778734·Recruiting·Listed Mar 2023

Apply to this trial

Family Support Protocol for Adolescent Internalizing Disorders

for Internalizing Disorders

Sites in Chicago +3 more locations

Sponsor: The National Center on Addiction and Substance Abuse at Columbia University

Sex: All·Age: 13 - 21

Code: NCT06413979·Recruiting·Listed May 2024

Apply to this trial

Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression

for Depression

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 60+

Code: NCT06591091·Phase 2·Recruiting·Listed Sep 2024

Apply to this trial

Community-based Approach to Lowering Stress Through Mindfulness

for Depression

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06987799·Recruiting·Listed May 2025

Apply to this trial

J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations

for HIV

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06477588·Recruiting·Listed Jun 2024

Apply to this trial

Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults

for Electronic Nicotine Delivery Systems

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 26·Accepts healthy volunteers

Code: NCT06395415·Recruiting·Listed May 2024

Apply to this trial

Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

for Schizophrenia Spectrum and Other Psychotic Disorders

Sites in Chicago +5 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 40

Code: NCT06740383·Recruiting·Listed Dec 2024

Apply to this trial

ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression

for Depression

Sites in Chicago +1 more location

Sponsor: Stanford University

Sex: All·Age: 18 - 60

Code: NCT06408246·Phase 2·Recruiting·Listed May 2024

Apply to this trial

Developing Evidence-Based Cognitive Approaches to Improve Adjustment to Vision Loss

for Depression, Anxiety

1 location in Chicago

Sponsor: The Chicago Lighthouse

Sex: All·Age: 18+

Code: NCT07073521·Recruiting·Listed Jul 2025

Apply to this trial

Evaluating Evidenced Based Options for PTSD Treatment

for PTSD - Post Traumatic Stress Disorder

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT06733376·Recruiting·Listed Dec 2024

Apply to this trial

Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset

for PTSD

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18 - 70

Code: NCT05700279·Recruiting·Listed Jan 2023

Apply to this trial

Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families

for Depression

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 12 - 55

Code: NCT06261463·Recruiting·Listed Feb 2024

Apply to this trial

Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans

for Chronic Pain

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT05094297·Recruiting·Listed Oct 2021

Apply to this trial

Fostering Optimal Regulation of Emotion for Prevention of Secondary Trauma (FOREST)

for Burnout

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05942469·Recruiting·Listed Jul 2023

Apply to this trial

Overcoming Nicotine Dependence to Enable Quitting

for Tobacco Use

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT05513872·Phase 1, Phase 2·Recruiting·Listed Aug 2022

Apply to this trial

Hip Arthroscopy Postoperative Opioid Demands

for Opioid Use

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT04094701·Recruiting·Listed Sep 2019

Apply to this trial

New Strategies to Enhance Smoking Cessation

for Smoking Cessation

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06751927·Recruiting·Listed Dec 2024

Apply to this trial

Massed Prolonged Exposure for PTSD in Substance Use Treatment

for Stress Disorders, Post-Traumatic

Sites in Chicago +3 more locations

Sponsor: Veterans Medical Research Foundation

Sex: All·Age: 18+

Code: NCT06296186·Recruiting·Listed Mar 2024

Apply to this trial

Digital InteGrated Behavioral TreatmeNt for Comorbid ObesITy and DeprEssion Among Racial and Ethnic Adults Age 50 and Older

for Obesity

Sites in Chicago +1 more location

Sponsor: University of Illinois at Chicago

Sex: All·Age: 50 - 74

Code: NCT06636058·Recruiting·Listed Oct 2024

Apply to this trial

Reducing Opioid Mortality in Illinois

for Opioid Use

Sites in Chicago, Waukegan +3 more locations

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04925427·Recruiting·Listed Jun 2021

Apply to this trial

Patient Outcome Reporting for Timely Assessments of Life With Post-Traumatic Stress Disorder

for PTSD

2 locations in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06479447·Recruiting·Listed Jun 2024

Apply to this trial

A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia

for Schizophrenia

Sites in Chicago +4 more locations

Sponsor: MapLight Therapeutics

Sex: All·Age: 18 - 65

Code: NCT07459647·Phase 2·Recruiting·Listed Mar 2026

Apply to this trial

Randomized Withdrawal Study in Patients With Schizophrenia

for Schizophrenia

Sites in Chicago +21 more locations

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT06961968·Phase 3·Recruiting·Listed May 2025

Apply to this trial

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

for Major Depressive Disorder (MDD)

Sites in Chicago +18 more locations

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT06830044·Phase 3·Recruiting·Listed Feb 2025

Apply to this trial

Study of ALTO-300 in MDD

for Major Depressive Disorder

Sites in Chicago +37 more locations

Sponsor: Alto Neuroscience

Sex: All·Age: 18 - 70

Code: NCT05922878·Phase 2·Recruiting·Listed Jun 2023

Apply to this trial

Study of ALTO-101 in Patients With Schizophrenia

for Schizophrenia

Sites in Chicago +12 more locations

Sponsor: Alto Neuroscience

Sex: All·Age: 21 - 55

Code: NCT06502964·Phase 2·Recruiting·Listed Jul 2024

Apply to this trial

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

for Major Depressive Disorder

Sites in Chicago +39 more locations

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06223880·Phase 4·Recruiting·Listed Jan 2024

Apply to this trial

Conditions in Behavioral health (Chicago, IL)

Depression· 34 Schizophrenia· 22 PTSD (post-traumatic stress disorder)· 10 Anxiety· 9 Opioid use disorder· 7 Substance use disorder· 7 Tobacco / nicotine use· 6 Alcohol use disorder· 5 ADHD· 2 Bipolar disorder· 1 Cannabis use / cannabis use disorder· 1