Behavioral health Clinical Trials in Chicago, IL
As of August 2026, 75 paid clinical trials are recruiting for Behavioral health in Chicago, Illinois. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Chicago
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
76 clinical trials for Behavioral health
·Clear filters·A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
A Study of Brenipatide in Adult Participants With Schizophrenia
A Study of Brenipatide in Participants With Opioid Use Disorder
An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
A Study of Brenipatide in Participants With Alcohol Use Disorder
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder
NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
RE104 Safety and Efficacy Study in Generalized Anxiety Disorder
A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively
Study to Evaluate LB-102 for the Treatment of Adult Patients With Acute Schizophrenia
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)
A Study to Evaluate the Effect of KarXT on Urological Safety
A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia
Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia
A Study of the Feasibility, Safety and Tolerability of Aticaprant as Adjunctive Treatment in Participants With Schizophrenia
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
Study to Assess the Safety, Tolerability, and Treatment Response of GXV813 in Hospitalized Adults With Schizophrenia
Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment and Reduction of Heavy Drinking in Individuals With of Alcohol Use Disorder (AUD)
A Study to Evaluate the Safety, Tolerability, and PK of an Injectable Form of KarXT
Remotely Observed Methadone Evaluation II
Multi-Site Trial of Tirzepatide for Smoking Cessation
Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression
E-Mindfulness Approaches for Living After Breast Cancer
Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury
Our Voices Matter: Intervention for Depression in Youth
Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder
Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older
Hip Arthroscopy Postoperative Opioid Demands
The Trans-Led Care Study
Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites
CLOZAPINE Response in Biotype-1
Top Research Study Locations in Chicago
Researchers run research studies in Chicago, IL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Northwestern University | Metastatic Malignant Solid Neoplasm, Prostate Adenocarcinoma, Stage IV Lung Cancer AJCC v8 | 346 |
| University of Chicago | Heart Failure, Peripheral Artery Disease, Gastric Cancer | 185 |
| Rush University Medical Center | Angelman Syndrome, Degenerative Disc Disease, Atrial Fibrillation | 157 |
| Ann & Robert H. Lurie Children's Hospital of Chicago | Diffuse Intrinsic Pontine Glioma, High Grade Glioma, WHO Grade III Glioma | 110 |
| University of Chicago Medical Center | Endometrial Cancer, Breast Cancer, Kidney Stone | 98 |
| University of Chicago Comprehensive Cancer Center | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome | 89 |
| Northwestern Memorial Hospital | Multiple Sclerosis, Heart Failure, Inguinal Hernia Bilateral | 85 |
| University of Illinois | Acute Myeloid Leukemia, Malignant Solid Neoplasm, Breast Cancer | 85 |
| University of Illinois at Chicago | Multiple Sclerosis, Carcinoma, Non-Small-Cell Lung, Chronic Stroke | 70 |
| Advocate Illinois Masonic Medical Center | Anatomic Stage II Breast Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Lung Non-Small Cell Carcinoma | 48 |
| The University of Chicago | Head and Neck Cancer, Malnutrition, AML With Gene Mutations | 44 |
| Shirley Ryan AbilityLab | Stroke, Multiple Sclerosis, Spinal Cord Injuries | 36 |
| University of Illinois Chicago | Breast Cancer Early Stage Breast Cancer (Stage 1-3), Type 1 Diabetes (T1D), ASCVD | 35 |
| Lurie Children's Hospital-Chicago | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm | 32 |
| Northwestern University Feinberg School of Medicine | Peripheral Artery Disease, Aging, Depression | 29 |
| Rush MD Anderson Cancer Center | Stage IVB Prostate Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 25 |
| John H Stroger Jr Hospital of Cook County | Anatomic Stage II Breast Cancer AJCC v8, Malignant Solid Neoplasm, Anatomic Stage I Breast Cancer AJCC v8 | 24 |
| Northwestern Medicine | AML - Acute Myeloid Leukemia, Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis (ALS) | 23 |
| Rush University | Preterm, AV Block, Acute Kidney Injury | 22 |
| University of Illinois Cancer Center | Breast Cancer, Gastric Cancer, Cervical Cancer | 22 |
| The University of Chicago Medical Center | Systemic Sclerosis, Acute Myeloid Leukemia, Interstitial Lung Diseases | 21 |
| University of Chicago Medicine Comprehensive Cancer Center | Carcinoma, Squamous Cell, Prostate Cancer, Acute Leukemia | 20 |
| Lurie Children's Hospital | Congenital Heart Disease (CHD), ACL Injury, ACL Tear | 18 |
| University of Chicago Medicine | Advanced Solid Tumor, Lung Cancer, Ulcerative Colitis | 16 |
| Lurie Children's Hospital of Chicago | Acute Kidney Injury, Duchenne Muscular Dystrophy, Neurofibromatosis 1 | 13 |
Active & Upcoming Studies in Chicago (2026)
Recruiting trials in Chicago grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (601 active studies)
- Futibatinib With Paclitaxel and Ramucirumab for the Treatment of Locally Advanced or Unresectable Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma · Phase 1 · Northwestern University
- Testing an Experimental Approach to Treat Patients With Plasma Cell Leukemia, The QUANTUM Trial · Phase 2 · National Cancer Institute (NCI)
Neurology & pain (149 active studies)
- Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures · Northwestern University
- COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE" · Phase 3 · Yale University
Cardiovascular (116 active studies)
- Mobile Health Management of Hypertension · University of Chicago
- PRECISION-CPR: PRecision-Controlled Ventilation in CPR · Rush University Medical Center
Diabetes & metabolic (108 active studies)
Mental health & behavior (77 active studies)
HIV / STI (33 active studies)
- A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs · NYU Langone Health
- A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
Pediatric (33 active studies)
- Reducing Disparities in Knee Arthroscopy for Adolescents · Ann & Robert H Lurie Children's Hospital of Chicago
- SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease · Phase 2 · Justin Ryder
Vaccines (19 active studies)
- A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of Age · Phase 3 · GlaxoSmithKline
- A Study to Characterize the Safety and Immunogenicity of AZD6489 in Participants 60 Years of Age and Older (ARIES) · Phase 1, Phase 2 · AstraZeneca
Eye & vision (9 active studies)
- Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS) · Phase 3 · Adverum Biotechnologies, Inc.
- A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults · Astellas Pharma Global Development, Inc.
Common conditions studied in Chicago
- Breast Cancer (35 active studies)
- Obesity (27 active studies)
- Stroke (25 active studies)
- Heart Failure (24 active studies)
- Acute Myeloid Leukemia (23 active studies)
- Hypertension (22 active studies)
Leading research sponsors in Chicago
- Northwestern University
- University of Chicago
- University of Illinois at Chicago
- National Cancer Institute (NCI)
- Rush University Medical Center
Frequently asked questions
How many paid clinical trials are currently recruiting in Chicago?
There are approximately 2,151 recruiting clinical trials in Chicago, Illinois listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Chicago pay participants?
Most recruiting trials in Chicago compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Chicago?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Chicago?
The most common conditions under active study in Chicago include Breast Cancer (35), Obesity (27), Stroke (25), Heart Failure (24), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Chicago?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Chicago on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Chicago?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Chicago?
Recruiting research sites in Chicago include Northwestern University, University of Chicago, Rush University Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Chicago right now?
The largest active categories in Chicago are Cancer & tumors (601), Neurology & pain (149), Cardiovascular (116). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.