Behavioral health Clinical Trials in Chicago, IL
As of July 2026, 73 paid clinical trials are recruiting for Behavioral health in Chicago, Illinois. Behavioral health trials span mental-health pharmacotherapy and addiction treatment — testing new agents and therapies for depression, anxiety, opioid use disorder, alcohol use, and tobacco cessation. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Chicago
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
A Study of the Feasibility, Safety and Tolerability of Aticaprant as Adjunctive Treatment in Participants With Schizophrenia
Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression
Multi-Site Trial of Tirzepatide for Smoking Cessation
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
78 clinical trials for Behavioral health
·Clear filters·↓ Download CSVAn Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)
A Study of Brenipatide in Adult Participants With Schizophrenia
A Study of Brenipatide in Participants With Opioid Use Disorder
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
A Study of Brenipatide in Participants With Alcohol Use Disorder
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
A Trial of the Efficacy and Safety of SEP-363856 in Acutely Psychotic Participants With Schizophrenia
"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder
Study of ITI-1284 as Monotherapy Treatment in Patients With Generalized Anxiety Disorder
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia
RE104 Safety and Efficacy Study in Generalized Anxiety Disorder
A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively
Study to Evaluate LB-102 for the Treatment of Adult Patients With Acute Schizophrenia
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)
A Study to Evaluate the Effect of KarXT on Urological Safety
A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia
Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia
Study to Assess the Safety, Tolerability, and Treatment Response of GXV813 in Hospitalized Adults With Schizophrenia
Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment of Alcohol Use Disorder (AUD)
A Study to Evaluate the Safety, Tolerability, and PK of an Injectable Form of KarXT
Remotely Observed Methadone Evaluation II
Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury
E-Mindfulness Approaches for Living After Breast Cancer
Our Voices Matter: Intervention for Depression in Youth
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The Trans-Led Care Study
Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites
CLOZAPINE Response in Biotype-1
Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder
Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection
About research studies in Chicago
Chicago has approximately 2,139 recruiting research studies across a wide range of therapeutic areas. Illinois's research base includes Northwestern Medicine, Rush University Medical Center, University of Chicago Medicine, and Ann & Robert H. Lurie Children's Hospital, covering oncology, cardiology, and pediatric specialties.
Top Research Study Locations in Chicago
Researchers run research studies in Chicago, IL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Northwestern University | Prostate Adenocarcinoma, Stage IV Lung Cancer AJCC v8, Acute Myeloid Leukemia | 340 |
| University of Chicago | Heart Failure, Peripheral Artery Disease, Endometrial Cancer | 182 |
| Rush University Medical Center | Angelman Syndrome, Degenerative Disc Disease, Atrial Fibrillation | 152 |
| Ann & Robert H. Lurie Children's Hospital of Chicago | High Grade Glioma, Diffuse Intrinsic Pontine Glioma, WHO Grade III Glioma | 113 |
| University of Chicago Medical Center | Breast Cancer, Endometrial Cancer, Kidney Stone | 96 |
| Northwestern Memorial Hospital | Heart Failure, Inguinal Hernia Bilateral, Inguinal Hernia Unilateral | 87 |
| University of Chicago Comprehensive Cancer Center | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome | 87 |
| University of Illinois | Acute Myeloid Leukemia, Malignant Solid Neoplasm, Breast Cancer | 84 |
| University of Illinois at Chicago | Multiple Sclerosis, Carcinoma, Non-Small-Cell Lung, Chronic Stroke | 72 |
| Advocate Illinois Masonic Medical Center | Anatomic Stage II Breast Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Lung Non-Small Cell Carcinoma | 50 |
| The University of Chicago | Head and Neck Cancer, Malnutrition, AML With Gene Mutations | 41 |
| Shirley Ryan AbilityLab | Stroke, Multiple Sclerosis, Spinal Cord Injuries | 37 |
| Lurie Children's Hospital-Chicago | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm | 35 |
| University of Illinois Chicago | Breast Cancer Early Stage Breast Cancer (Stage 1-3), HIV Infections, Type 1 Diabetes (T1D) | 33 |
| Northwestern University Feinberg School of Medicine | Peripheral Artery Disease, Aging, Depression | 29 |
| John H Stroger Jr Hospital of Cook County | Anatomic Stage II Breast Cancer AJCC v8, Malignant Solid Neoplasm, Anatomic Stage I Breast Cancer AJCC v8 | 27 |
| Rush MD Anderson Cancer Center | Stage IVB Prostate Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 24 |
| University of Illinois Cancer Center | Breast Cancer, Gastric Cancer, Cervical Cancer | 24 |
| Rush University | Preterm, AV Block, Acute Kidney Injury | 23 |
| Northwestern Medicine | Urologic Diseases, AML - Acute Myeloid Leukemia, Amyotrophic Lateral Sclerosis | 21 |
| The University of Chicago Medical Center | Systemic Sclerosis, Acute Myeloid Leukemia, Ovarian Cancer | 21 |
| University of Chicago Medicine Comprehensive Cancer Center | Carcinoma, Squamous Cell, Prostate Cancer, Acute Leukemia | 19 |
| Lurie Children's Hospital | Congenital Heart Disease (CHD), ACL Injury, ACL Tear | 17 |
| University of Chicago Medicine | Advanced Solid Tumor, Lung Cancer, Ulcerative Colitis | 17 |
| Lurie Children's Hospital of Chicago | Acute Kidney Injury, Duchenne Muscular Dystrophy, Neurofibromatosis 1 | 13 |
Active & Upcoming Studies in Chicago (2026)
Recruiting trials in Chicago grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (594 active studies)
- BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion · Phase 1, Phase 2 · Northwestern University
- Futibatinib With Paclitaxel and Ramucirumab for the Treatment of Locally Advanced or Unresectable Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma · Phase 1 · Northwestern University
Neurology & pain (152 active studies)
- Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures · Northwestern University
- Behavioral Intervention for Lifestyle Physical Activity in Parkinson's Disease · University of Illinois at Chicago
Cardiovascular (113 active studies)
- Mobile Health Management of Hypertension · University of Chicago
- PRECISION-CPR: PRecision-Controlled Ventilation in CPR · Rush University Medical Center
Diabetes & metabolic (102 active studies)
Mental health & behavior (82 active studies)
- A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs · NYU Langone Health
- Effects of Stimulant Medications in PTSD · Phase 1 · University of Chicago
HIV / STI (37 active studies)
- A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs · NYU Langone Health
- A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
Pediatric (32 active studies)
- Reducing Disparities in Knee Arthroscopy for Adolescents · Ann & Robert H Lurie Children's Hospital of Chicago
- SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease · Phase 2 · Justin Ryder
Vaccines (18 active studies)
- A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Administered as Intramuscular Injection to Healthy Children 15 Months to 6 Years of Age · Phase 3 · GlaxoSmithKline
- Cognitive-Sensorimotor Function in Long-COVID · VA Office of Research and Development
Eye & vision (11 active studies)
- Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS) · Phase 3 · Adverum Biotechnologies, Inc.
- A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults · Astellas Pharma Global Development, Inc.
Common conditions studied in Chicago
- Breast Cancer (37 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Heart Failure (28 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Stroke (26 active studies). Stroke trials test acute reperfusion strategies, neuroprotective agents, and rehabilitation technologies to improve recovery.
- Acute Myeloid Leukemia (23 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
- Hypertension (23 active studies). Hypertension research tests new antihypertensive drug classes, renal denervation devices, and fixed-dose combinations for resistant disease.
- Obesity (23 active studies). Obesity trials evaluate GLP-1 and GIP receptor agonists, novel metabolic drugs, and combined lifestyle interventions for sustainable weight loss.
Leading research sponsors in Chicago
- Northwestern University
- University of Chicago
- University of Illinois at Chicago
- National Cancer Institute (NCI)
- Rush University Medical Center
Local regulations and guidelines
Clinical trials in Illinois are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Illinois studies must also comply with the Illinois Personal Information Protection Act (PIPA) and Biometric Information Privacy Act (BIPA) where applicable.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Chicago. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Chicago
Hipa.ai aggregates every recruiting study in Chicago from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Chicago?
There are approximately 2,139 recruiting clinical trials in Chicago, Illinois listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Chicago pay participants?
Most recruiting trials in Chicago compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Chicago?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Chicago?
The most common conditions under active study in Chicago include Breast Cancer (37), Heart Failure (28), Stroke (26), Acute Myeloid Leukemia (23), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Chicago?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Chicago on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Chicago?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Chicago?
Recruiting research sites in Chicago include Northwestern University, University of Chicago, Rush University Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Chicago right now?
The largest active categories in Chicago are Cancer & tumors (594), Neurology & pain (152), Cardiovascular (113). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.