Paid Clinical Trials in Chicago, IL

As of July 2026, 2,152 paid clinical trials are recruiting in Chicago, Illinois. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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1,897 clinical trials

An Observational Study of Individuals With Isolated Dystonia

for Isolated/Primary Dystonia That Affects More Than One Region of the Body

Sites in Chicago +28 more locations

Sponsor: Vima Therapeutics

Sex: All·Age: 12 - 65

Code: NCT07111663·Recruiting·Listed Aug 2025

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IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)

for Advanced Melanoma

Drug: Nivolumab

Sites in Chicago +32 more locations

Sponsor: Immunocore Ltd

Sex: All·Age: 18+

Code: NCT06112314·Phase 3·Recruiting·Listed Nov 2023

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Zenith® Fenestrated+ Clinical Study

for Aortic Aneurysm, Abdominal

Sites in Chicago, Maywood +28 more locations

Sponsor: Cook Research Incorporated

Sex: All·Age: 18+

Code: NCT04875429·Recruiting·Listed May 2021

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J-Valve Transfemoral Pivotal Study

for Aortic Valve Regurgitation

Sites in Chicago, Glenview +32 more locations

Sponsor: JC Medical, Inc., an affiliate of Edwards Lifesciences LLC

Sex: All·Age: 18+

Code: NCT06455787·Recruiting·Listed Jun 2024

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A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancer

for Gastroesophageal-junction Cancer

Sites in Chicago +28 more locations

Sponsor: Shanghai Henlius Biotech

Sex: All·Age: 18+

Code: NCT06532006·Phase 3·Recruiting·Listed Aug 2024

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Real-world Experience on Using Nemolizumab in the Treatment of Moderate-to- Severe Prurigo Nodularis in Adults

for Prurigo Nodularis

Drug: Nemolizumab

Sites in Chicago +38 more locations

Sponsor: Galderma R&D

Sex: All·Age: 18+

Code: NCT06988618·Recruiting·Listed May 2025

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Shield Post-Approval Study Protocol

for Colo-rectal Cancer

Sites in Chicago, Oak Lawn +43 more locations

Sponsor: Guardant Health, Inc.

Sex: All·Age: 45 - 81·Accepts healthy volunteers

Code: NCT06880055·Recruiting·Listed Mar 2025

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A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Chicago, Maywood +42 more locations

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT05735184·Phase 1·Recruiting·Listed Feb 2023

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A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma

for Choroidal Melanoma

Sites in Chicago +33 more locations

Sponsor: Aura Biosciences

Sex: All·Age: 18+

Code: NCT06007690·Phase 3·Recruiting·Listed Aug 2023

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A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

for Gastrointestinal Stromal Tumor (GIST)

Sites in Chicago +31 more locations

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06655246·Phase 1·Recruiting·Listed Oct 2024

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Endovascular AAA Intervention Using the GORE® EXCLUDER® Conformable AAA Endoprosthesis or Iliac Branch Endoprosthesis

for AAA - Abdominal Aortic Aneurysm

Sites in Chicago, Evanston +54 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06218875·Recruiting·Listed Jan 2024

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Study to Evaluate the Efficacy and Safety of Deuruxolitinib in Adolescents With Severe Alopecia Areata

for Alopecia Areata

Sites in Chicago +53 more locations

Sponsor: Sun Pharmaceutical Industries, Inc.

Sex: All·Age: 12 - 17

Code: NCT07133308·Phase 3·Recruiting·Listed Aug 2025

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A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants

for Hypothyroidism

Sites in Chicago +129 more locations

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT06345339·Phase 2, Phase 3·Recruiting·Listed Apr 2024

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A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)

for Extensive Stage-small Cell Lung Cancer

Drug: Atezolizumab

Sites in Chicago +24 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06362252·Phase 1, Phase 2·Recruiting·Listed Apr 2024

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Trial to Evaluate the Safety and Effectiveness of Treatment With COMS One Device in Subjects With Diabetic Foot Ulcers

for Diabetic Foot Ulcer

Sites in Chicago, O'Fallon +24 more locations

Sponsor: Piomic Medical

Sex: All·Age: 22 - 90

Code: NCT05758545·Recruiting·Listed Mar 2023

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EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

for Breast Cancer

Sites in Chicago +52 more locations

Sponsor: Exact Sciences Corporation

Sex: All·Age: 18+

Code: NCT06401421·Recruiting·Listed May 2024

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MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

for Breast Cancer

Sites in Chicago, Oak Lawn +111 more locations

Sponsor: Agendia

Sex: All·Age: 18+

Code: NCT03053193·Recruiting·Listed Feb 2017

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Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type

for Agitation

Sites in Chicago +26 more locations

Sponsor: Suven Life Sciences Limited

Sex: All·Age: 50 - 90

Code: NCT05397639·Phase 3·Recruiting·Listed May 2022

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A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).

for Pediatric

Drug: Aficamten

Sites in Chicago +24 more locations

Sponsor: Cytokinetics

Sex: All·Age: 12 - 17

Code: NCT06412666·Phase 2, Phase 3·Recruiting·Listed May 2024

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Autologous Hair Follicle Derived Secretome as Adjunct to Aesthetic Procedures

for Post Procedural Erythema

Sites in Chicago +19 more locations

Sponsor: Acorn Biolabs Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06477172·Recruiting·Listed Jun 2024

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Real-world Experience Using Nemolizumab in the Treatment of Moderate-to-Severe Atopic Dermatitis in Adolescents & Adults

for Atopic Dermatitis

Drug: Nemolizumab

Sites in Chicago +57 more locations

Sponsor: Galderma R&D

Sex: All·Age: 12+

Code: NCT06988605·Recruiting·Listed May 2025

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A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)

for Chronic Graft-versus-host-disease

Sites in Chicago +12 more locations

Sponsor: Syndax Pharmaceuticals

Sex: All·Age: 2+

Code: NCT04710576·Phase 2·Recruiting·Listed Jan 2021

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A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)

for Chronic Graft-Versus-Host Disease (cGVHD)

Sites in Chicago +25 more locations

Sponsor: Deciphera Pharmaceuticals, LLC

Sex: All·Age: 18+

Code: NCT06619561·Phase 2·Recruiting·Listed Oct 2024

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PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

for Aortic Stenosis, Calcific

Sites in Chicago, Lisle +48 more locations

Sponsor: Edwards Lifesciences

Sex: All·Age: 65+

Code: NCT04889872·Recruiting·Listed May 2021

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(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

for Advanced Gastrointestinal Stromal Tumors

Sites in Chicago +7 more locations

Sponsor: Cogent Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05208047·Phase 3·Recruiting·Listed Jan 2022

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US National OCS Heart Perfusion (OHP) Registry

for Heart Transplant

Sites in Chicago +36 more locations

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT05915299·Recruiting·Listed Jun 2023

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Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

for Prostate Cancer

Sites in Chicago +29 more locations

Sponsor: Janux Therapeutics

Sex: Male·Age: 18 - 100

Code: NCT05519449·Phase 1·Recruiting·Listed Aug 2022

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A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

for Treatment Resistant Depression

Sites in Chicago +33 more locations

Sponsor: atai Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06524830·Phase 2·Recruiting·Listed Jul 2024

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CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.

for Epithelial Ovarian Cancer

Sites in Chicago +25 more locations

Sponsor: TORL Biotherapeutics, LLC

Sex: Female·Age: 18+

Code: NCT06690775·Phase 2·Recruiting·Listed Nov 2024

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A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants

for Bronchopulmonary Dysplasia

Sites in Chicago +23 more locations

Sponsor: OHB Neonatology Ltd.

Sex: All·Age: 0 Hours - 24 Hours

Code: NCT03253263·Phase 2·Recruiting·Listed Aug 2017

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Study of ITI-1284 as Monotherapy Treatment in Patients With Generalized Anxiety Disorder

for Generalized Anxiety Disorder

Sites in Chicago +24 more locations

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 18+

Code: NCT06701903·Phase 2·Recruiting·Listed Nov 2024

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Tissue Repair Gel in Venous Leg Ulcers (US)

for Venous Leg Ulcer

Sites in Chicago, Springfield +25 more locations

Sponsor: TR Therapeutics

Sex: All·Age: 18+

Code: NCT06707090·Phase 3·Recruiting·Listed Nov 2024

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A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

for Major Depressive Disorder

Sites in Chicago +44 more locations

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18 - 74

Code: NCT06775379·Phase 3·Recruiting·Listed Jan 2025

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A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

for Stereotypical Prolonged Seizures

Sites in Chicago, Springfield +45 more locations

Sponsor: UCB Biopharma SRL

Sex: All·Age: 12+

Code: NCT05077904·Phase 3·Recruiting·Listed Oct 2021

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Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Esophagus

for Esophageal Stricture

Sites in Chicago +33 more locations

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561114·Phase 3·Recruiting·Listed Sep 2022

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Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Bowel

for Bowel

Sites in Chicago +32 more locations

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561127·Phase 3·Recruiting·Listed Sep 2022

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CAR-T Long Term Follow Up (LTFU) Study

for Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program

Sites in Chicago +40 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 0 - 100

Code: NCT02445222·Phase 3·Recruiting·Listed May 2015

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SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

for Cancer, Metastatic

Sites in Chicago +66 more locations

Sponsor: Massive Bio, Inc.

Sex: All·Age: All ages

Code: NCT03452774·Recruiting·Listed Mar 2018

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PARTNER 3 Trial - Aortic Valve-in-Valve

for Aortic Stenosis

Sites in Chicago +28 more locations

Sponsor: Edwards Lifesciences

Sex: All·Age: All ages

Code: NCT03003299·Recruiting·Listed Dec 2016

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A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet in Women With Uterine Fibroids or Endometriosis

for Uterine Fibroids

Drug: Relugolix

Sites in Chicago, Schaumburg +118 more locations

Sponsor: Sumitomo Pharma Switzerland GmbH

Sex: Female·Age: 18 - 50

Code: NCT05862272·Phase 3·Recruiting·Listed May 2023

Apply to this trial