Paid Clinical Trials in Chicago, IL

As of September 2026, 2,139 paid clinical trials are recruiting in Chicago, Illinois. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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1,881 clinical trials

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A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)

for Chronic Graft-Versus-Host Disease (cGVHD)

Sites in Chicago +25 more locations

Sponsor: Deciphera Pharmaceuticals, LLC

Sex: All·Age: 18+

Code: NCT06619561·Phase 2·Recruiting·Listed Oct 2024

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PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

for Aortic Stenosis, Calcific

Sites in Chicago, Lisle +48 more locations

Sponsor: Edwards Lifesciences

Sex: All·Age: 65+

Code: NCT04889872·Recruiting·Listed May 2021

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Autologous Hair Follicle Derived Secretome as Adjunct to Aesthetic Procedures

for Post Procedural Erythema

Sites in Chicago +19 more locations

Sponsor: Acorn Biolabs Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06477172·Recruiting·Listed Jun 2024

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US National OCS Heart Perfusion (OHP) Registry

for Heart Transplant

Sites in Chicago +36 more locations

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT05915299·Recruiting·Listed Jun 2023

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Real-world Experience Using Nemolizumab in the Treatment of Moderate-to-Severe Atopic Dermatitis in Adolescents & Adults

for Atopic Dermatitis

Drug: Nemolizumab

Sites in Chicago +57 more locations

Sponsor: Galderma R&D

Sex: All·Age: 12+

Code: NCT06988605·Recruiting·Listed May 2025

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CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.

for Epithelial Ovarian Cancer

Sites in Chicago +25 more locations

Sponsor: TORL Biotherapeutics, LLC

Sex: Female·Age: 18+

Code: NCT06690775·Phase 2·Recruiting·Listed Nov 2024

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A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)

for Chronic Graft-versus-host-disease

Sites in Chicago +12 more locations

Sponsor: Syndax Pharmaceuticals

Sex: All·Age: 2+

Code: NCT04710576·Phase 2·Recruiting·Listed Jan 2021

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(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

for Advanced Gastrointestinal Stromal Tumors

Sites in Chicago +7 more locations

Sponsor: Cogent Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05208047·Phase 3·Recruiting·Listed Jan 2022

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Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Esophagus

for Esophageal Stricture

Sites in Chicago +33 more locations

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561114·Phase 3·Recruiting·Listed Sep 2022

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Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Bowel

for Bowel

Sites in Chicago +32 more locations

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561127·Phase 3·Recruiting·Listed Sep 2022

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CAR-T Long Term Follow Up (LTFU) Study

for Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program

Sites in Chicago +40 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 0 - 100

Code: NCT02445222·Phase 3·Recruiting·Listed May 2015

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Tissue Repair Gel in Venous Leg Ulcers (US)

for Venous Leg Ulcer

Sites in Chicago, Springfield +25 more locations

Sponsor: TR Therapeutics

Sex: All·Age: 18+

Code: NCT06707090·Phase 3·Recruiting·Listed Nov 2024

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A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

for Treatment Resistant Depression

Sites in Chicago +33 more locations

Sponsor: atai Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06524830·Phase 2·Recruiting·Listed Jul 2024

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SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

for Cancer, Metastatic

Sites in Chicago +66 more locations

Sponsor: Massive Bio, Inc.

Sex: All·Age: All ages

Code: NCT03452774·Recruiting·Listed Mar 2018

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PARTNER 3 Trial - Aortic Valve-in-Valve

for Aortic Stenosis

Sites in Chicago +28 more locations

Sponsor: Edwards Lifesciences

Sex: All·Age: All ages

Code: NCT03003299·Recruiting·Listed Dec 2016

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A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet in Women With Uterine Fibroids or Endometriosis

for Uterine Fibroids

Drug: Relugolix

Sites in Chicago, Schaumburg +118 more locations

Sponsor: Sumitomo Pharma Switzerland GmbH

Sex: Female·Age: 18 - 50

Code: NCT05862272·Phase 3·Recruiting·Listed May 2023

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CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)

for Relapsed Hematologic Malignancy

Drug: Emavusertib

Sites in Chicago +17 more locations

Sponsor: Curis, Inc.

Sex: All·Age: 18+

Code: NCT03328078·Phase 1, Phase 2·Recruiting·Listed Nov 2017

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Fontan Udenafil Exercise Longitudinal Assessment Trial - 2

for Single Ventricle Heart Disease

Sites in Chicago +36 more locations

Sponsor: Mezzion Pharma Co. Ltd

Sex: All·Age: 12 - 18

Code: NCT05918211·Phase 3·Recruiting·Listed Jun 2023

Apply to this trial

NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

for Aortic Dissection

Sites in Chicago +23 more locations

Sponsor: Endospan Ltd.

Sex: All·Age: 18+

Code: NCT04471909·Recruiting·Listed Jul 2020

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Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

for Neurotrophic Keratopathy

Sites in Chicago +23 more locations

Sponsor: ReGenTree, LLC

Sex: All·Age: 18+

Code: NCT05555589·Phase 3·Recruiting·Listed Sep 2022

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EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

for COVID-19

Sites in Chicago +23 more locations

Sponsor: Pfizer

Sex: All·Age: 0 - 17

Code: NCT05261139·Phase 3·Recruiting·Listed Mar 2022

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Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

for Lung Cancer Diagnosis

Sites in Chicago, Deerfield +34 more locations

Sponsor: Freenome Holdings Inc.

Sex: All·Age: 50+

Code: NCT06122077·Recruiting·Listed Nov 2023

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To Evaluate the Safety and Efficacy of MANP in Subjects With Difficult to Control/ Resistant Hypertension

for Difficult to Control Hypertension

Sites in Chicago +25 more locations

Sponsor: E-Star BioTech, LLC

Sex: All·Age: 18 - 80

Code: NCT06343298·Phase 2·Recruiting·Listed Apr 2024

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AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

for Heart Failure

Sites in Chicago, Downers Grove +35 more locations

Sponsor: Cordio Medical

Sex: All·Age: 22+

Code: NCT06378632·Recruiting·Listed Apr 2024

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A Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation

for AML

Sites in Chicago +25 more locations

Sponsor: TScan Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07702578·Phase 3·Recruiting·Listed Jul 2026

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A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

for Obesity

Sites in Chicago, Skokie +32 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07595549·Phase 3·Recruiting·Listed May 2026

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A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity

for Obesity

Drug: NNC0662-0419

Sites in Chicago +23 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07639021·Phase 2·Recruiting·Listed Jun 2026

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Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

for Pancreatic Cancer

Drug: Atebimetinib

Sites in Chicago, Arlington Heights +37 more locations

Sponsor: Immuneering Corporation

Sex: All·Age: 18+

Code: NCT07562152·Phase 3·Recruiting·Listed May 2026

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Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema

for Diabetic Retinopathy

Drug: Surabgene Lomparvovec

Sites in Chicago, Oak Forest +28 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07592273·Phase 2, Phase 3·Recruiting·Listed May 2026

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A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

for Depressive Disorder, Major

Drug: Seltorexant

Sites in Chicago +30 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT07573176·Phase 3·Recruiting·Listed May 2026

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AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

for Obesity

Drug: NNC0487-0111

Sites in Chicago +16 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07571005·Phase 3·Recruiting·Listed May 2026

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AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

for Obesity

Drug: NNC0487-0111

Sites in Chicago +19 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07571109·Phase 3·Recruiting·Listed May 2026

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Efficacy of the Omnipod® 6 System Compared With the Omnipod® 5 System

for Type 2 Diabetes Mellitus

Sites in Chicago +10 more locations

Sponsor: Insulet Corporation

Sex: All·Age: 14 - 75

Code: NCT07579702·Recruiting·Listed May 2026

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A Study to Learn About the Safety of an Expanded Pneumococcal Vaccine in Healthy Infants

for Pneumococcal Disease

Sites in Chicago +20 more locations

Sponsor: Pfizer

Sex: All·Age: 42 Days - 98 Days·Accepts healthy volunteers

Code: NCT07573462·Phase 3·Recruiting·Listed May 2026

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A Phase 2 Trial of Dotinurad in Xanthine Oxidase Inhibitor (XOI) Intolerant/Uricase Failure Gout Participants

for Gout

Drug: Dotinurad

Sites in Chicago +37 more locations

Sponsor: Crystalys Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07535034·Phase 2·Recruiting·Listed Apr 2026

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A Study Comparing JNJ-79635322 and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Teclistamab

Sites in Chicago +34 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07518186·Phase 3·Recruiting·Listed Apr 2026

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Evaluation of the Fully Closed Loop Omnipod® System in Type 2 Diabetes

for Type 2 Diabetes Mellitus

Sites in Chicago +25 more locations

Sponsor: Insulet Corporation

Sex: All·Age: 18 - 75

Code: NCT07521475·Recruiting·Listed Apr 2026

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A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease

for Colitis, Ulcerative

Sites in Chicago +12 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07483073·Phase 2·Recruiting·Listed Mar 2026

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A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease

for Crohn Disease

Drug: LY4395089

Sites in Chicago +12 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07483099·Phase 2·Recruiting·Listed Mar 2026

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RE104 Safety and Efficacy Study in Generalized Anxiety Disorder

for Generalized Anxiety Disorder

Sites in Chicago +27 more locations

Sponsor: Reunion Neuroscience Inc

Sex: All·Age: 18 - 74

Code: NCT07489651·Phase 2·Recruiting·Listed Mar 2026

Apply to this trial