A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity

Part of paid clinical trials in Montgomery, Alabama.

Sponsor
Novo Nordisk A/S
Study ID
NCT07639021
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • NNC0662-0419 — DRUG
    NNC0662-0419 will be administered subcutaneously.
  • Semaglutide — DRUG
    Semaglutide will be administered subcutaneously.
  • NNC0662-0419 Placebo — DRUG
    Placebo matched to NNC0662-0419 will be administered subcutaneously.
  • Semaglutide placebo — DRUG
    Placebo matched to semaglutide will be administered subcutaneously.

Study Details

The purpose of the study is to find out if NNC0662-0419 is safe and effective for treating participants living with obesity.

Key Dates

Start date
Jun 9, 2026
Status verified
Jun 2026
Primary completion
Jul 12, 2027
Completion
Jul 12, 2027

Study Design

Enrollment
230 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: NNC0662-0419
    Participants will receive NNC0662-0419 administered subcutaneously in a dose-escalation manner.
  • Placebo Comparator: NNC0662-0419 placebo
    Participants will receive NNC0662-0419 placebo administered subcutaneously in a dose-escalation manner.
  • Experimental: Semaglutide
    Participants will receive semaglutide administered subcutaneously in a dose-escalation manner.
  • Placebo Comparator: Semaglutide placebo
    Participants will receive semaglutide placebo administered subcutaneously in a dose-escalation manner.

Primary Outcome Measure

Number of gastrointestinal adverse events [ Time Frame: From week 0 to week 39 ]

Central Contacts

Locations (24)

FacilityCityStateZIPSite coordinators
Chambliss Clinical Trials, LLCMontgomeryAlabama36106-
FDRCCosta MesaCalifornia92627-
Los Angeles Institute for Metabolic ResearchLos AngelesCalifornia90015-
Encore Medical Research LLCHollywoodFlorida33024-
South Broward Research LLCMiramarFlorida33027-
West Orange EndocrinologyOcoeeFlorida34761-
Cedar-Crosse Research CenterChicagoIllinois60607-
Great Lakes Clinical TrialsChicagoIllinois60640-
Midwest Inst For Clin ResIndianapolisIndiana46260-
L-MARC Research CenterLouisvilleKentucky40213-
Endo And Metab ConsRockvilleMaryland20852-
StudyMetrix Research LLCCity of Saint PetersMissouri63303-
Great Lakes Medical ResearchWestfieldNew York14787-
KDCILM, LLC & Accellacare US, Inc.WilmingtonNorth Carolina28401-
Family Practice Center of Wadsworth Inc.WadsworthOhio44281-9236-
UPA Ctr Weight and Eating DisPhiladelphiaPennsylvania19104-
Clinical Res CollaborativeCumberlandRhode Island02864-
Holston Medical Group_BristolBristolTennessee37620-
Holston Medical GroupKingsportTennessee37660-
Clinical Research AssociatesNashvilleTennessee37203-
PlanIt Research, PLLCHoustonTexas77079-
Pinnacle Clinical ResearchSan AntonioTexas78222-
National Clin Res Inc.RichmondVirginia23294-
Rainier Clin Res Ctr IncRentonWashington98057-

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