Heart disease Clinical Trials in Cleveland, OH

As of July 2026, 57 paid clinical trials are recruiting for Heart disease in Cleveland, Ohio. Heart disease research tests new drug therapies, device-based interventions, and lifestyle programs for heart failure, atrial fibrillation, hypertension, and coronary disease — including therapies that reduce hospitalization and cardiovascular death. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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59 clinical trials for Heart disease

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OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP)

for Hypertension

1 location in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 50+

Code: NCT05293756·Recruiting·Listed Mar 2022

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Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

for Diabetic Nephropathies

Drug: Sotagliflozin

Sites in Cleveland +12 more locations

Sponsor: Alessandro Doria

Sex: All·Age: 18 - 75

Code: NCT06217302·Phase 3·Recruiting·Listed Jan 2024

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Vascular Events In Patients Undergoing Same-day Noncardiac Surgery (VALIANCE) Study

for Preoperative Care

Sites in Cleveland +4 more locations

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All·Age: 45+

Code: NCT04973397·Recruiting·Listed Jul 2021

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Remote Monitoring in Pregnant Women With Congenital Heart Disease Using Wrist Wearables

for Congenital Heart Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Female·Age: 18+

Code: NCT06818760·Recruiting·Listed Feb 2025

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Left vs Left Randomized Clinical Trial

for Heart Failure

Sites in Cleveland, Cincinnati +55 more locations

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting·Listed Dec 2022

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TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

for Atrial Fibrillation

Drug: Tirzepatide

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 80

Code: NCT06802081·Phase 2·Recruiting·Listed Jan 2025

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Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

for Atrial Fibrillation

Sites in Cleveland +1 more location

Sponsor: The Cleveland Clinic

Sex: All·Age: 22+

Code: NCT07122947·Recruiting·Listed Aug 2025

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Vascular Lab Resource (VLR) Biorepository

for Cardiovascular Diseases

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT05628948·Recruiting·Listed Nov 2022

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A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure

for Heart Failure

Sites in Cleveland +1 more location

Sponsor: Tufts Medical Center

Sex: All·Age: 18 - 100

Code: NCT05627440·Recruiting·Listed Nov 2022

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Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

for Acute Myocardial Infarction

Sites in Cleveland +12 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT05701358·Recruiting·Listed Jan 2023

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The GUARDIAN Trial

for Blood Pressure

Sites in Cleveland +1 more location

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 45+

Code: NCT04884802·Recruiting·Listed May 2021

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Intracardiac Echocardiography Guided Watchman Device Implant

for Atrial Fibrillation

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06007872·Recruiting·Listed Aug 2023

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Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation

for Heart Failure

Sites in Cleveland +3 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06291922·Recruiting·Listed Mar 2024

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The Oxford Risk Factors And Non-Invasive Imaging Study

for Cardiovascular Diseases

Sites in Cleveland +2 more locations

Sponsor: University of Oxford

Sex: All·Age: 18 - 99

Code: NCT05169333·Recruiting·Listed Dec 2021

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Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"

for Heart Failure

1 location in Cleveland

Sponsor: NHS Greater Glasgow and Clyde

Sex: All·Age: 40+

Code: NCT05919342·Recruiting·Listed Jun 2023

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Product Surveillance Registry

for Cardiac Rhythm Disorders

Sites in Cleveland, Columbus +127 more locations

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT01524276·Recruiting·Listed Feb 2012

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Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

for Arrhythmia

Sites in Cleveland, Toledo +83 more locations

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT00271180·Recruiting·Listed Dec 2005

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Conditions in Heart disease (Cleveland, OH)

Heart failure· 26 Cardiovascular disease (general)· 20 Atrial fibrillation· 14 Coronary artery disease· 13 Hypertension (high blood pressure)· 7 Congenital heart disease· 3 Myocardial infarction (heart attack)· 1