Oncology Clinical Trials in Durham, NC

As of September 2026, 206 paid clinical trials are recruiting for Oncology in Durham, North Carolina. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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206 clinical trials for Oncology

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Cognitive Behavioral Theory-assisted Virtual Reality for Chronic CANcer Pain (VR-CAN)

for Cancer

Sites in Durham +1 more location

Sponsor: Medstar Health Research Institute

Sex: All·Age: 18+

Code: NCT07318519·Recruiting·Listed Jan 2026

Apply to this trial

A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer

for Prostate Cancer

Sites in Durham +11 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: Male·Age: 18+

Code: NCT06457919·Phase 1, Phase 2·Recruiting·Listed Jun 2024

Apply to this trial

IL-17 Blockade to Decrease irAEs (REPLAY)

for Metastatic Melanoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07237594·Phase 1·Recruiting·Listed Nov 2025

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Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

Sites in Durham, Chapel Hill +3 more locations

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05145400·Phase 2·Recruiting·Listed Dec 2021

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Cryocompression to Reduce Chemotherapy-induced Peripheral Neuropathy in Gynecologic Cancer - COHORT 2

for Gynecologic Cancer

Sites in Durham +3 more locations

Sponsor: Duke University

Sex: Female·Age: 18+

Code: NCT06139458·Recruiting·Listed Nov 2023

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Preserving Physical Function in Older Adults With Cancer: Impact of an Optimizing Nutrition Intervention Applied Before and After Surgery

for Cancer

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 55+

Code: NCT05912257·Recruiting·Listed Jun 2023

Apply to this trial

Improving Outcomes in Early Menopause After Cancer

for Early Menopause

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 44

Code: NCT06982677·Recruiting·Listed May 2025

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A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study

for Hematopoietic and Lymphatic System Neoplasm

Sites in Durham, Winston-Salem +74 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 15 - 20

Code: NCT06410209·Phase 2·Recruiting·Listed May 2024

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REVITALIZE: RCT to Reduce Fatigue in Adults With Ovarian Cancer on PARP Inhibitors

for Ovarian Cancer

Sites in Durham +5 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18+

Code: NCT06710548·Recruiting·Listed Nov 2024

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Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

for High Grade Glioma

Drug: Ribociclib

Sites in Durham +10 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05843253·Phase 2·Recruiting·Listed May 2023

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Characterizing the Microvascular Environment of Bladder Cancer With Super-Resolution Ultrasound Localization Microscopy

for Bladder Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06986304·Recruiting·Listed May 2025

Apply to this trial

SDM POSSIBLE: A Breast Cancer Treatment Decision Aid for Women 70+ With Low-Risk Stage I Breast Cancers

for Breast Cancer

Sites in Durham +10 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06896474·Recruiting·Listed Mar 2025

Apply to this trial

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

for High Grade Glioma

Sites in Durham +8 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: Up to 21

Code: NCT04655404·EARLY_Phase 1·Recruiting·Listed Dec 2020

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Exercise and Soft Tissue Sarcoma

for Soft Tissue Sarcoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 85

Code: NCT04921917·Recruiting·Listed Jun 2021

Apply to this trial

Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers

for Lung Carcinoma

Sites in Durham +15 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06196008·Recruiting·Listed Jan 2024

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Pilot Study of Mindset Moments Among Adolescent and Young Adult Cancer Survivors

for Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 19 - 25·Accepts healthy volunteers

Code: NCT06732375·Recruiting·Listed Dec 2024

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Engage Psychosocial Intervention for Cancer Symptoms

for Advanced Breast Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06555588·Recruiting·Listed Aug 2024

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Cervical Cancer Detection Using Optical Spectroscopy

for Cervical Cancer

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT00900575·Recruiting·Listed May 2009

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Pilot Study for Speculum Free Cervical Cancer Screening

for Cervical Cancer

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 21 - 65·Accepts healthy volunteers

Code: NCT04107181·Recruiting·Listed Sep 2019

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Trans-Rectal Ultrasound of the Female Pelvis for Real-Time MRI-US Fusion Based Needle Tracking

for Uterine Cancer

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 90

Code: NCT05977621·Recruiting·Listed Aug 2023

Apply to this trial

Cancer and Mild Cognitive Impairment Dyadic Intervention

for Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 100

Code: NCT05144516·Recruiting·Listed Dec 2021

Apply to this trial

Role of Ablative Radiotherapy in the Management of Metastatic Disease: A Patient Data Registry

for Oligometastasis

Sites in Durham, Cary & Raleigh

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT04085029·Recruiting·Listed Sep 2019

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TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

for BRCA1 Gene Mutation

Sites in Durham +10 more locations

Sponsor: University Medical Center Nijmegen

Sex: Female·Age: 25 - 50

Code: NCT04294927·Recruiting·Listed Mar 2020

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Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors

for Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 39

Code: NCT06371768·Recruiting·Listed Apr 2024

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Key Longitudinal Associations With Risk and Glioblastoma Outcomes

for Glioblastoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06625684·Recruiting·Listed Oct 2024

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Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

for Head and Neck Cancer

Sites in Durham +3 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05793151·Recruiting·Listed Mar 2023

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Excision of Lymph Node Trial (EXCILYNT) (Mel69)

for Melanoma

Sites in Durham +6 more locations

Sponsor: Craig L Slingluff, Jr

Sex: All·Age: 18+

Code: NCT05839912·Recruiting·Listed May 2023

Apply to this trial

HMCT/CT2401: Abatacept GVHD Prophylaxis Following Omidubicel HCT

for Hematologic Malignancy

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06731504·EARLY_Phase 1·Recruiting·Listed Dec 2024

Apply to this trial

Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

for Metastatic Breast Cancer

Sites in Durham +2 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06795529·Recruiting·Listed Jan 2025

Apply to this trial

Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients

for Liver Cancer

2 locations in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT04933435·Recruiting·Listed Jun 2021

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A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

for Esophageal Adenocarcinoma

Sites in Durham +6 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05563766·Phase 2·Recruiting·Listed Oct 2022

Apply to this trial

ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials

for Prostate Cancer

Sites in Durham +2 more locations

Sponsor: Duke University

Sex: Male·Age: 18+

Code: NCT06141993·Recruiting·Listed Nov 2023

Apply to this trial

A Randomized Phase II Study Of Bruton Tyrosine Kinase Inhibitor With Or Without Venetoclax In Veterans With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

for Chronic Lymphocytic Leukemia

Drug: Venetoclax

Sites in Durham +3 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 80

Code: NCT06520098·Phase 2·Recruiting·Listed Jul 2024

Apply to this trial

Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma

for Mesothelioma

Drug: Tremelimumab

Sites in Durham +1 more location

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05932199·Phase 1, Phase 2·Recruiting·Listed Jul 2023

Apply to this trial

Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

for Prostate Cancer

Sites in Durham +15 more locations

Sponsor: VA Office of Research and Development

Sex: Male·Age: 18+

Code: NCT04787744·Phase 2, Phase 3·Recruiting·Listed Mar 2021

Apply to this trial

A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib

for Myelofibrosis

Drug: Ruxolitinib

Sites in Durham, Winston-Salem +28 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07623161·Phase 3·Recruiting·Listed Jun 2026

Apply to this trial

A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

for Solid Tumors

Sites in Durham +15 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07492680·Phase 2·Recruiting·Listed Mar 2026

Apply to this trial

Weight Management After Cancer for Survivors in Rural Communities

for Breast Cancer Survivorship

Sites in Durham, Henderson +3 more locations

Sponsor: Duke University

Sex: Female·Age: 18+

Code: NCT07426952·Recruiting·Listed Feb 2026

Apply to this trial

DESTINY-PANTUMOUR04

for Adenocarcinoma (NOS)

Sites in Durham, Wilson +16 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT07124000·Recruiting·Listed Aug 2025

Apply to this trial

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

for Esophageal Squamous Cell Carcinoma

Sites in Durham +9 more locations

Sponsor: Plexium, Inc.

Sex: All·Age: 18+

Code: NCT07284186·Phase 1·Recruiting·Listed Dec 2025

Apply to this trial

Conditions in Oncology (Durham, NC)

Solid tumor· 35 Breast cancer· 24 Prostate cancer· 20 Cancer (any)· 20 Non-small cell lung cancer (NSCLC)· 15 Colorectal cancer· 15 Pancreatic cancer· 12 Ovarian cancer· 11 Acute myeloid leukemia (AML)· 11 Multiple myeloma· 9 Metastatic prostate cancer· 8 Endometrial cancer· 8 Glioblastoma· 8 Chronic lymphocytic leukemia (CLL)· 8 Non-Hodgkin lymphoma· 8 Hematologic malignancy· 8 Head and neck cancer· 8 Metastatic breast cancer· 7 Glioma· 7 Melanoma· 6 Lung cancer· 5 Bladder cancer· 5 Myelodysplastic syndromes (MDS)· 5 Myelofibrosis· 5 Mantle cell lymphoma· 5 Triple-negative breast cancer· 4 Esophageal cancer· 4 Cervical cancer· 4 Follicular lymphoma· 4 Sarcoma· 4 Neuroblastoma· 4 HER2-negative breast cancer· 3 Liver cancer· 3 Kidney cancer· 3 Acute lymphoblastic leukemia· 3 Leukemia (other)· 3 Diffuse large B-cell lymphoma (DLBCL)· 3 Small lymphocytic lymphoma· 3 Osteosarcoma· 3 HER2-positive breast cancer· 2 Small cell lung cancer· 2 Gastric cancer· 2 Biliary tract cancer· 2 Fallopian tube cancer· 2 Chronic myelomonocytic leukemia· 2 Marginal zone lymphoma· 2 Thyroid cancer· 2 Metastatic colorectal cancer· 1 Colon cancer· 1 Gastroesophageal junction cancer· 1 Gastrointestinal cancer· 1 Uterine cancer· 1 Gynecologic cancer· 1 Brain metastases· 1 Myeloproliferative neoplasm· 1 Hodgkin lymphoma· 1 Burkitt lymphoma· 1 Soft tissue sarcoma· 1 Mesothelioma· 1