MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
for Lumbar Spinal Stenosis
Sites in Guilford, North Haven +2367 more locations
Sponsor: Stryker Instruments
Sex: All·Age: 18+
Code: NCT03072927·Recruiting·Listed Mar 2017
Paid Clinical Trials in Guilford, CT
As of August 2026, 51 paid clinical trials are recruiting in Guilford, Connecticut. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Guilford offers studies at sites including Smilow Cancer Hospital Care Center - Guilford for conditions such as Anatomic Stage II Breast Cancer AJCC v8, Breast Cancer, Stage IV Lung Cancer AJCC v8, Recurrent Lung Non-Small Cell Carcinoma. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Guilford
Trials by drug in Guilford
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51 clinical trials
A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.
for Breast Cancer
Sites in Guilford, North Haven +100 more locations
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT07062965·Phase 3·Recruiting·Listed Jul 2025
A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer
for Breast Cancer
Sites in Guilford, North Haven +132 more locations
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT06966453·Phase 1, Phase 2·Recruiting·Listed May 2025
Skin Color Matching in Head and Neck Reconstructive Surgery
for Head and Neck Cancer
Sites in Guilford, New Haven & Milford
Sponsor: Yale University
Sex: All·Age: 18+
Code: NCT07431099·Recruiting·Listed Feb 2026
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
for Breast Cancer
Sites in Guilford, North Haven +1098 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 18 - 60
Code: NCT05879926·Phase 3·Recruiting·Listed May 2023
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
for Lung Non-Small Cell Carcinoma
Sites in Guilford, North Haven +632 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT04267848·Phase 3·Recruiting·Listed Feb 2020
Time to BBVNA Relief
for Low Back Pain
Sites in Guilford, New Haven & Old Saybrook
Sponsor: Yale University
Sex: All·Age: 18+
Code: NCT07433634·Recruiting·Listed Feb 2026
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
for Stage III Colon Cancer
Sites in Guilford, North Haven +913 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
for Anatomic Stage II Breast Cancer AJCC v8
Sites in Guilford, North Haven +777 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT05812807·Phase 3·Recruiting·Listed Apr 2023
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
for Anatomic Stage I Breast Cancer AJCC v8
Sites in Guilford, North Haven +591 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT06876714·Phase 3·Recruiting·Listed Mar 2025
Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial
for Advanced Hepatocellular Carcinoma
Sites in Guilford, North Haven +136 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT07166406·Phase 3·Recruiting·Listed Sep 2025
Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer
for Advanced Lung Non-Squamous Non-Small Cell Carcinoma
Drug: Bevacizumab
Sites in Guilford, North Haven +325 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT04181060·Phase 3·Recruiting·Listed Nov 2019
Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer
for Anatomic Stage II Breast Cancer AJCC v8
Drug: Durvalumab
Sites in Guilford, North Haven +532 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT06058377·Phase 3·Recruiting·Listed Sep 2023
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
for Head and Neck Squamous Cell Carcinoma
Sites in Guilford, North Haven +464 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT02734537·Phase 2·Recruiting·Listed Apr 2016
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial
for Extensive Stage Lung Small Cell Carcinoma
Drug: Atezolizumab
Sites in Guilford, North Haven +268 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT04402788·Phase 2, Phase 3·Recruiting·Listed May 2020
Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer
for Clear Cell Renal Cell Carcinoma
Sites in Guilford, New Haven +406 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT06661720·Phase 3·Recruiting·Listed Oct 2024
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study
for Muscle Invasive Bladder Urothelial Carcinoma
Sites in Guilford, North Haven +445 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT05987241·Phase 2, Phase 3·Recruiting·Listed Aug 2023
Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer
for Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma
Sites in Guilford, North Haven +314 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT06958328·Phase 3·Recruiting·Listed May 2025
Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer
for Refractory Differentiated Thyroid Gland Carcinoma
Sites in Guilford, North Haven +284 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT06475989·Phase 3·Recruiting·Listed Jun 2024
Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma
for Mantle Cell Lymphoma
Sites in Guilford, North Haven +228 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 60+
Code: NCT05976763·Phase 3·Recruiting·Listed Aug 2023
Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial
for Advanced Esophageal Adenocarcinoma
Drug: Nivolumab
Sites in Guilford, North Haven +339 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT06203600·Phase 2, Phase 3·Recruiting·Listed Jan 2024
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab
for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
Drug: Nivolumab
Sites in Guilford, North Haven +378 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 5 - 60
Code: NCT05675410·Phase 3·Recruiting·Listed Jan 2023
Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma
for Smoldering Plasma Cell Myeloma
Drug: Daratumumab
Sites in Guilford, North Haven +486 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT03937635·Phase 3·Recruiting·Listed May 2019
The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study
for Metastatic Breast Cancer
Sites in Guilford, North Haven +71 more locations
Sponsor: American Society of Clinical Oncology
Sex: All·Age: 65+
Code: NCT06377852·Phase 3·Recruiting·Listed Apr 2024
Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas
for Metastatic Dedifferentiated Liposarcoma
Sites in Guilford, New Haven +237 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT06422806·Phase 3·Recruiting·Listed May 2024
Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment
for Plasma Cell Myeloma
Sites in Guilford, North Haven +387 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: All ages
Code: NCT05561387·Phase 3·Recruiting·Listed Sep 2022
Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
for Previously Treated Non-Small Cell Lung Cancer
Sites in Guilford, North Haven +948 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT03851445·Phase 2, Phase 3·Recruiting·Listed Feb 2019
Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers
for Pancreatic Neoplasm
Sites in Guilford, North Haven +334 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 50 - 75
Code: NCT04239573·Recruiting·Listed Jan 2020
Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)
for Recurrent Lung Non-Small Cell Carcinoma
Sites in Guilford, North Haven +370 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT05642572·Phase 2·Recruiting·Listed Dec 2022
Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma
for High Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements
Sites in Guilford, New Haven +55 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT06649812·Phase 2·Recruiting·Listed Oct 2024
Testing the Combination of the Anticancer Drug Durvalumab With Chemotherapy (Gemcitabine and Cisplatin) at Improving Outcomes for High-Risk Resectable Liver Cancer Before Surgery
for Resectable Intrahepatic Cholangiocarcinoma
Drug: Durvalumab
Sites in Guilford, North Haven +50 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT06050252·Phase 2·Recruiting·Listed Sep 2023
QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer
for HER2-positive Metastatic Breast Cancer
Sites in Guilford, New Haven +35 more locations
Sponsor: Abramson Cancer Center at Penn Medicine
Sex: All·Age: 18+
Code: NCT06551116·Recruiting·Listed Aug 2024
ATEMPT 2.0: Adjuvant T-DM1 vs TH
for Breast Cancer
Sites in Guilford, North Haven +44 more locations
Sponsor: Dana-Farber Cancer Institute
Sex: All·Age: 18+
Code: NCT04893109·Phase 2·Recruiting·Listed May 2021
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
for Stage I Breast Cancer
Sites in Guilford, North Haven +705 more locations
Sponsor: NRG Oncology
Sex: All·Age: 50 - 70
Code: NCT04852887·Phase 3·Recruiting·Listed Apr 2021
Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)
for Recurrent Lung Non-Small Cell Carcinoma
Drug: Cemiplimab
Sites in Guilford, North Haven +379 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT06616584·Phase 2, Phase 3·Recruiting·Listed Sep 2024
Testing Teclistamab (TECVAYLI) in Combination With Iberdomide for Relapsed or Refractory Multiple Myeloma
for Recurrent Multiple Myeloma
Drug: Teclistamab
Sites in Guilford, North Haven +12 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT06465316·Phase 1·Recruiting·Listed Jun 2024
Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)
for Recurrent Lung Non-Small Cell Carcinoma
Sites in Guilford, North Haven +239 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18 Minutes+
Code: NCT06031688·Phase 2·Recruiting·Listed Sep 2023
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
for Retroperitoneal Sarcoma
Sites in Guilford, North Haven +95 more locations
Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
Sex: All·Age: 18+
Code: NCT04031677·Phase 3·Recruiting·Listed Jul 2019
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
for Anatomic Stage IV Breast Cancer AJCC v8
Sites in Guilford, North Haven +584 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT03723928·Recruiting·Listed Oct 2018
Dose-Deescalated 3-Fraction Stereotactic Body Radiotherapy For Centrally Located Lung Cancer
for Non-small Cell Lung Cancer
Sites in Guilford, New Haven +4 more locations
Sponsor: Yale University
Sex: All·Age: 18+
Code: NCT04210492·Phase 1, Phase 2·Recruiting·Listed Dec 2019
Top Research Study Locations in Guilford
Researchers run research studies in Guilford, CT at 10 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Smilow Cancer Hospital Care Center - Guilford | Anatomic Stage II Breast Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Recurrent Lung Non-Small Cell Carcinoma | 41 |
| Smilow Cancer Hospital - Guilford | Breast Cancer, Breast Neoplasms | 2 |
| SCA Guilford Surgery Center | Lumbar Spinal Stenosis | 1 |
| Shoreline Surgery Center | Head and Neck Cancer, Head and Neck Trauma | 1 |
| Smilow Cancer Hospital Care Center | HER2-positive Metastatic Breast Cancer | 1 |
| Smilow Cancer Hospital Care Center - Guiford | Leiomyosarcoma, Liposarcoma, Retroperitoneal Sarcoma | 1 |
| Smilow Cancer Hospital Care center at Guilford | Breast Cancer, HER2-positive Breast Cancer | 1 |
| Smilow Hospital Care Center, Guilford | Cutaneous Melanoma, Stage II | 1 |
| Yale New Haven Shoreline Medical Center | Opioid Use Disorder | 1 |
| Yale Spine and Pain Center - Guilford | Basivertebral Nerve Ablation, Low Back Pain, Vertebrogenic Pain Syndrome | 1 |
Active & Upcoming Studies in Guilford (2026)
Recruiting trials in Guilford grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (44 active studies)
Neurology & pain (1 active study)
- Time to BBVNA Relief · Yale University
Common conditions studied in Guilford
- Anatomic Stage II Breast Cancer AJCC v8 (4 active studies)
- Breast Cancer (4 active studies)
- Stage IV Lung Cancer AJCC v8 (4 active studies)
- Recurrent Lung Non-Small Cell Carcinoma (3 active studies)
- Anatomic Stage I Breast Cancer AJCC v8 (2 active studies)
- Anatomic Stage IIIA Breast Cancer AJCC v8 (2 active studies)
Leading research sponsors in Guilford
- SWOG Cancer Research Network
- National Cancer Institute (NCI)
- NRG Oncology
- Alliance for Clinical Trials in Oncology
- ECOG-ACRIN Cancer Research Group
Frequently asked questions
How many paid clinical trials are currently recruiting in Guilford?
There are approximately 51 recruiting clinical trials in Guilford, Connecticut listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Guilford pay participants?
Most recruiting trials in Guilford compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Guilford?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Guilford?
The most common conditions under active study in Guilford include Anatomic Stage II Breast Cancer AJCC v8 (4), Breast Cancer (4), Stage IV Lung Cancer AJCC v8 (4), Recurrent Lung Non-Small Cell Carcinoma (3), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Guilford?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Guilford on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Guilford?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Guilford?
Recruiting research sites in Guilford include Smilow Cancer Hospital Care Center - Guilford, Smilow Cancer Hospital - Guilford, SCA Guilford Surgery Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Guilford right now?
The largest active categories in Guilford are Cancer & tumors (44), Neurology & pain (1). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
Browse more clinical trials
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