Paid Clinical Trials in Illinois

Illinois has 2,847 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,519 clinical trials

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Evaluating the Efficacy of a Vocational Counseling Intervention to Improve Occupational Functioning and Employment Quality Among Veterans With Mental Health and Substance Use Disorders

for Unemployment

Sites in Hines +2 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07097376·Recruiting·Listed Jul 2025

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Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

for Urothelial Cancer

Sites in Peoria, Niles +6 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT07129993·Phase 2, Phase 3·Recruiting·Listed Aug 2025

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Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade Glioma

for Ependymoma

1 location in Chicago

Sponsor: Cerenome

Sex: All·Age: 6 - 21

Code: NCT07061626·Phase 1·Recruiting·Listed Jul 2025

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A Phase 1/2 Study of the Safety and Efficacy of MVX-220 in Angelman Syndrome

for Angelman Syndrome

Sites in Chicago +2 more locations

Sponsor: MavriX Bio, LLC

Sex: All·Age: 4 - 50

Code: NCT07181837·Phase 1, Phase 2·Recruiting·Listed Sep 2025

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A Phase 3 Randomized Clinical Trial to Investigate the Safety and Efficacy of Palopegteriparatide at Doses Greater Than 30 μg/Day in Adult Participants With Hypoparathyroidism

for Hypoparathyroidism

Drug: Palopegteriparatide

Sites in Chicago +6 more locations

Sponsor: Ascendis Pharma Bone Diseases A/S

Sex: All·Age: 18+

Code: NCT07081997·Phase 3·Recruiting·Listed Jul 2025

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Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

for Chronic Inflammatory Demyelinating Polyneuropathy

Sites in Chicago +32 more locations

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18+

Code: NCT07032662·Phase 2·Recruiting·Listed Jun 2025

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Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

for Hypertriglyceridemia

Sites in Springfield +6 more locations

Sponsor: Marea Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07028749·Phase 2·Recruiting·Listed Jun 2025

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A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis

for Atopic Dermatitis

Sites in Skokie +22 more locations

Sponsor: Apogee Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07003425·Phase 2·Recruiting·Listed Jun 2025

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DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

for Endometrial Cancer

Drug: Rilvegostomig

Sites in Evanston, Arlington Heights +45 more locations

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT06989112·Phase 3·Recruiting·Listed May 2025

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A Study to Determine if BHV-8000 is Effective, Safe and Tolerable as a Treatment for Adults Living With Early Parkinson's Disease

for Parkinson Disease

Sites in Chicago +18 more locations

Sponsor: Biohaven Therapeutics Ltd.

Sex: All·Age: 40 - 80

Code: NCT06976268·Phase 2, Phase 3·Recruiting·Listed May 2025

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A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE

for Lupus Erythematosus, Systemic

Sites in Chicago +13 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 70

Code: NCT06897930·Phase 1, Phase 2·Recruiting·Listed Mar 2025

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Paired-Ring Mitral Annuloplasty Ring Sizing Device

for Heart Valve Diseases

1 location in Glenview

Sponsor: Endeavor Health

Sex: All·Age: 18+

Code: NCT06965725·Recruiting·Listed May 2025

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A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

for Cardiovascular Disease

Sites in Chicago, Arlington Heights +308 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07000357·Phase 3·Recruiting·Listed Jun 2025

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A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

for HER2-positive Gastric Cancer

Drug: Rilvegostomig

Sites in Chicago, Evanston +44 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06764875·Phase 3·Recruiting·Listed Jan 2025

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Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Drug: Rilvegostomig

Sites in Chicago +31 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06921785·Phase 3·Recruiting·Listed Apr 2025

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Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response

for Arthritis, Psoriatic

Sites in Springfield +35 more locations

Sponsor: MoonLake Immunotherapeutics AG

Sex: All·Age: 18+

Code: NCT06641089·Phase 3·Recruiting·Listed Oct 2024

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Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL

for B-cell Non-Hodgkin Lymphoma

Sites in Chicago +15 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06526793·Phase 2·Recruiting·Listed Jul 2024

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Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

for Heart Failure and Impaired Kidney Function

Drug: Dapagliflozin

Sites in Chicago, Peoria +108 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06307652·Phase 3·Recruiting·Listed Mar 2024

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An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants

for Systemic Lupus Erythematosus

Sites in Chicago +19 more locations

Sponsor: AstraZeneca

Sex: All·Age: 5 - 17

Code: NCT05835310·Phase 3·Recruiting·Listed Apr 2023

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A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

for Heart Failure

Drug: Finerenone

Sites in Peoria, Glenview +44 more locations

Sponsor: Colorado Prevention Center

Sex: All·Age: 18+

Code: NCT06024746·Phase 3·Recruiting·Listed Sep 2023

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A Study to Compare the Efficacy, Safety and Tolerability of FF/UMEC/VI With FF/VI in 12-17-year-olds With Asthma

for Asthma

Sites in Normal +19 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 12 - 17

Code: NCT05757102·Phase 3·Recruiting·Listed Mar 2023

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A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease

for Systemic Sclerosis Associated Interstitial Lung Disease

Sites in Chicago +21 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT05878717·Phase 2, Phase 3·Recruiting·Listed May 2023

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Observational Study Protocol: LIVER-R

for Hepatobiliary Cancers

Sites in Hinsdale, Evergreen Park +22 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06252753·Recruiting·Listed Feb 2024

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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Winfield, Palos Hills +66 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06883305·Phase 3·Recruiting·Listed Mar 2025

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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Evanston, Springfield +60 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06878261·Phase 3·Recruiting·Listed Mar 2025

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Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression

for Acute Lymphoblastic Leukaemia

Sites in Decatur +4 more locations

Sponsor: AstraZeneca

Sex: All·Age: 16+

Code: NCT07155226·Phase 1, Phase 2·Recruiting·Listed Sep 2025

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Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

for Metastatic Malignant Solid Neoplasm

Sites in Chicago +17 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05372614·Phase 1·Recruiting·Listed May 2022

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Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

for Endometrial Carcinoma

Sites in Chicago, Evanston +327 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT05256225·Phase 3·Recruiting·Listed Feb 2022

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A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

for Locally Advanced Head and Neck Squamous Cell Carcinoma

Sites in Niles +44 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06129864·Phase 3·Recruiting·Listed Nov 2023

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Testing the Addition of Duvelisib or CC-486 to the Usual Treatment for Peripheral T-Cell Lymphoma

for Angioimmunoblastic T-cell Lymphoma

Sites in Chicago, Urbana +84 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT04803201·Phase 2·Recruiting·Listed Mar 2021

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Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

for Advanced Breast Cancer

Drug: Camizestrant

Sites in Chicago, Evanston +38 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06380751·Phase 3·Recruiting·Listed Apr 2024

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Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE

for Hereditary Angioedema (HAE)

Sites in Wheaton +12 more locations

Sponsor: Pharvaris Netherlands B.V.

Sex: All·Age: 12+

Code: NCT06679881·Phase 3·Recruiting·Listed Nov 2024

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A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

for Accelerated Phase Myeloproliferative Neoplasm

Drug: Iadademstat

Sites in Chicago, Orland Park +29 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06661915·Phase 2·Recruiting·Listed Oct 2024

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Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

for Viral Lung Infection and Acute Respiratory Failure

Sites in Evanston +35 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05624450·Phase 3·Recruiting·Listed Nov 2022

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A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee

for Osteoarthritis (OA) of the Knee

Sites in Chicago +26 more locations

Sponsor: Pacira Pharmaceuticals, Inc

Sex: All·Age: 45 - 80

Code: NCT06884865·Phase 2·Recruiting·Listed Mar 2025

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Preventative Screening and Health Coaching in a Food Insecure Population

for Cardiovascular Disease Prevention

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 40 - 75

Code: NCT06907524·Recruiting·Listed Apr 2025

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A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

for Prostate Cancer

Drug: Saruparib

Sites in Chicago, Chicago Ridge +35 more locations

Sponsor: AstraZeneca

Sex: Male·Age: 18+

Code: NCT06952803·Phase 3·Recruiting·Listed May 2025

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Our Peers - Empowerment and Navigational Support - Community Living (OP-ENS-CL): A Peer Navigator Intervention for Adults With Acquired Physical Disabilities

for Disabled Persons

2 locations in Chicago

Sponsor: Susan Magasi

Sex: All·Age: 18+

Code: NCT06941233·Recruiting·Listed Apr 2025

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A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure

for Chronic Kidney Disease and Hypertension

Drug: Dapagliflozin

Sites in Maywood, Rockford +115 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06742723·Phase 3·Recruiting·Listed Dec 2024

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A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of Creatinine in a Non Interventional Cohort

for Chronic Kidney Disease

Sites in Chicago +3 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07024823·Phase 1·Recruiting·Listed Jun 2025

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