Paid Clinical Trials in Illinois

Illinois has 2,847 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,519 clinical trials

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A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease

for COPD (Chronic Obstructive Pulmonary Disease)

Sites in Chicago, Winfield +132 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06283966·Phase 3·Recruiting·Listed Feb 2024

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Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

Drug: Osimertinib

Sites in Hinsdale, North Chicago +27 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06350097·Phase 3·Recruiting·Listed Apr 2024

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Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

for Non-small Cell Lung Cancer

Sites in Chicago +17 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06218914·Phase 1·Recruiting·Listed Jan 2024

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Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

Sites in Chicago +18 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 95

Code: NCT05061550·Phase 2·Recruiting·Listed Sep 2021

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NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial

for Atrial Fibrillation

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT06511505·Recruiting·Listed Jul 2024

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A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

for Breast Cancer

Drug: Durvalumab

Sites in Chicago +35 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06103864·Phase 3·Recruiting·Listed Oct 2023

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A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients

for Untreated Follicular Lymphoma

Drug: Rituximab

Sites in Peoria, Evanston +55 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06549595·Phase 3·Recruiting·Listed Aug 2024

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Cognitive Training as an Adjunct to Ketamine in Real-world Clinics

for Depression

Sites in Chicago +2 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 80

Code: NCT06526078·Recruiting·Listed Jul 2024

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Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

for Biliary Tract Cancer

Drug: Rilvegostomig

Sites in Chicago, Niles +29 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT06467357·Phase 3·Recruiting·Listed Jun 2024

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Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

for Transthyretin Amyloidosis

Sites in Chicago +32 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06465810·Recruiting·Listed Jun 2024

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Impact of Removable Cast Walker Design on Usability for Patients With Diabetic Foot Ulcers

for Diabetes Mellitus

1 location in North Chicago

Sponsor: Rosalind Franklin University of Medicine and Science

Sex: All·Age: 18+

Code: NCT05415878·Recruiting·Listed Jun 2022

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AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia

for B-cell Acute Lymphoblastic Leukemia (B-ALL)

Sites in Chicago +9 more locations

Sponsor: AstraZeneca

Sex: All·Age: 12+

Code: NCT06137118·Phase 1, Phase 2·Recruiting·Listed Nov 2023

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A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism

for Tumor Hyperinsulinism (Tumor HI)

Sites in Chicago +7 more locations

Sponsor: Rezolute

Sex: All·Age: 18+

Code: NCT06881992·Phase 3·Recruiting·Listed Mar 2025

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A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

for Metastatic Colorectal Cancer

Sites in Chicago +10 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06792695·Phase 2·Recruiting·Listed Jan 2025

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Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

for Metastatic Clear Cell Renal Cell Carcinoma

Drug: Cabozantinib

Sites in Zion +45 more locations

Sponsor: Arcus Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT07011719·Phase 3·Recruiting·Listed Jun 2025

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AZD0120 in Relapsed/Refractory Multiple Myeloma (DURGA-1)

for Relapsed/Refractory Multiple Myeloma

Sites in Chicago +33 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05850234·Phase 1, Phase 2·Recruiting·Listed May 2023

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Study of the Shockwave Medical SkyRunner Carotid Intravascular Lithotripsy (IVL) System for the Treatment of Calcified Carotid Arteries Prior to Trans-Carotid Stenting (SKYWARD Trans-Carotid IDE [Investigational Device Exemption] Study)

for Carotid Artery Calcification

Sites in Park Ridge +24 more locations

Sponsor: Shockwave Medical, Inc.

Sex: All·Age: 18+

Code: NCT07062471·Recruiting·Listed Jul 2025

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Alleviant ALLAY-HFrEF Study

for Heart Failure

Sites in Naperville +38 more locations

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 18+

Code: NCT06812533·Recruiting·Listed Feb 2025

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A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Disease on Hemodialysis With a Central Venous Catheter (Phase IIa)

for Staphylococcus Aureus

Sites in Chicago +39 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT06749457·Phase 1, Phase 2·Recruiting·Listed Dec 2024

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Non-Squamous NSCLC

for Non-squamous Non-small Cell Lung Cancer

Drug: Rilvegostomig

Sites in Chicago, Decatur +59 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06627647·Phase 3·Recruiting·Listed Oct 2024

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Alleviant ALLAY-HF Study

for Heart Failure

Sites in Naperville +42 more locations

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 40+

Code: NCT05685303·Recruiting·Listed Jan 2023

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

Drug: Rilvegostomig

Sites in Chicago, Decatur +63 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06692738·Phase 3·Recruiting·Listed Nov 2024

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RESET-MG: A Study to Evaluate the Safety and Efficacy of CABA-201 in Participants With Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis (gMG)

Sites in Chicago +16 more locations

Sponsor: Cabaletta Bio

Sex: All·Age: 18 - 70

Code: NCT06359041·Phase 1, Phase 2·Recruiting·Listed Apr 2024

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Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma

for Asthma

Sites in Normal +95 more locations

Sponsor: AstraZeneca

Sex: All·Age: 12 - 17

Code: NCT06307665·Phase 3·Recruiting·Listed Mar 2024

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Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

for Non-Small Cell Lung Cancer

Drug: Rilvegostomig

Sites in Hinsdale +48 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06357533·Phase 3·Recruiting·Listed Apr 2024

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Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

for Advanced Solid Malignancies

Sites in Chicago +7 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT05417594·Phase 1, Phase 2·Recruiting·Listed Jun 2022

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Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

Drug: IMVT-1402

Sites in Schaumburg +47 more locations

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18 - 80

Code: NCT07039916·Phase 3·Recruiting·Listed Jun 2025

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Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

for Endometrial Cancer

Sites in Chicago, Peoria +65 more locations

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT07044336·Phase 3·Recruiting·Listed Jun 2025

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Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known as the COMPOSE Study)

for Homocystinuria

Sites in Chicago +2 more locations

Sponsor: Travere Therapeutics, Inc.

Sex: All·Age: 5 - 65

Code: NCT03406611·Phase 1, Phase 2·Recruiting·Listed Jan 2018

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Maternal Mindfulness: Depression and Postpartum Pain

for Depression, Unipolar

1 location in Champaign

Sponsor: University of Illinois at Urbana-Champaign

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05400382·Recruiting·Listed Jun 2022

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PSMA PET Combined With MRI for the Detection of PCa

for PCA

Sites in Chicago +15 more locations

Sponsor: Telix Pharmaceuticals (Innovations) Pty Limited

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT07052214·Phase 3·Recruiting·Listed Jul 2025

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

for Carcinoma, Non-Small Cell Lung

Drug: Rilvegostomig

Sites in Chicago, Decatur +37 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06868277·Phase 3·Recruiting·Listed Mar 2025

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Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Acute Lymphoblastic Leukemia

for B-cell Acute Lymphoblastic Leukemia (B-ALL)

Sites in Chicago +4 more locations

Sponsor: AstraZeneca

Sex: All·Age: 12+

Code: NCT07109219·Phase 1, Phase 2·Recruiting·Listed Aug 2025

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Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias

for Spinocerebellar Ataxia Type 1

Sites in Chicago +13 more locations

Sponsor: Lauren Moore

Sex: All·Age: 6+·Accepts healthy volunteers

Code: NCT01060371·Recruiting·Listed Feb 2010

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Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

for Heart Failure

Drug: Dapagliflozin

Sites in Chicago, Park Ridge +175 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40+

Code: NCT06677060·Phase 3·Recruiting·Listed Nov 2024

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Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma

for Clear Cell Renal Cell Carcinoma

Sites in Chicago +19 more locations

Sponsor: Xencor, Inc.

Sex: All·Age: 18+

Code: NCT05433142·Phase 1·Recruiting·Listed Jun 2022

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A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)

for Systemic Sclerosis

Sites in Chicago +14 more locations

Sponsor: Nkarta, Inc.

Sex: All·Age: 18 - 75

Code: NCT06733935·Phase 1, Phase 2·Recruiting·Listed Dec 2024

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Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)

for Pulmonary Arterial Hypertension

Sites in Chicago +28 more locations

Sponsor: Gossamer Bio USA, Inc.

Sex: All·Age: 18 - 75

Code: NCT06274801·Phase 3·Recruiting·Listed Feb 2024

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A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease

for Proteinuric Kidney Disease

Drug: MZE829

Sites in Chicago, Evanston +66 more locations

Sponsor: Maze Therapeutics

Sex: All·Age: 18 - 68

Code: NCT06830629·Phase 2·Recruiting·Listed Feb 2025

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Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)

for Excessive Sleepiness

Drug: Solriamfetol

Sites in Chicago +40 more locations

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06568367·Phase 3·Recruiting·Listed Aug 2024

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