IKS04 Regimen in Advanced Solid Tumors That Express CA242
for Colorectal Cancer
Sites in Nashville +3 more locations
Sponsor: Iksuda Therapeutics Ltd.
Sex: All·Age: 18+
Code: NCT07738939·Phase 1·Not Yet Recruiting·Listed Jul 31, 2026
Colorectal cancer Clinical Trials in Nashville, TN
As of August 2026, 38 paid clinical trials are recruiting for Colorectal cancer in Nashville, Tennessee. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Nashville
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
39 clinical trials for Colorectal cancer
·Clear filters· Email me when a new colorectal cancer trial opens in Nashville, TN.
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
for Intestinal Neoplasms
Drug: PF-08634404
Sites in Nashville +199 more locations
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT07222800·Phase 3·Recruiting·Listed Oct 2025
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
for Colorectal Neoplasms
Sites in Nashville +107 more locations
Sponsor: Seagen, a wholly owned subsidiary of Pfizer
Sex: All·Age: 18+
Code: NCT05253651·Phase 3·Recruiting·Listed Feb 2022
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
for Colorectal Neoplasms
Drug: Amivantamab
Sites in Nashville, Chattanooga +65 more locations
Sponsor: Janssen Research & Development, LLC
Sex: All·Age: 18+
Code: NCT06750094·Phase 3·Recruiting·Listed Dec 2024
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
for Colorectal Neoplasms
Drug: Amivantamab
Sites in Nashville +79 more locations
Sponsor: Janssen Research & Development, LLC
Sex: All·Age: 18+
Code: NCT06662786·Phase 3·Recruiting·Listed Oct 2024
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
for Metastatic Breast Cancer
Drug: Zongertinib
Sites in Nashville, Memphis +24 more locations
Sponsor: Boehringer Ingelheim
Sex: All·Age: 18+
Code: NCT06324357·Phase 1, Phase 2·Recruiting·Listed Mar 2024
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
for Pancreatic Ductal Adenocarcinoma
Sites in Nashville +24 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT06586515·Phase 1·Recruiting·Listed Sep 2024
FOG-001 in Locally Advanced or Metastatic Solid Tumors
for Cancer
Sites in Nashville +29 more locations
Sponsor: Parabilis Medicines, Inc.
Sex: All·Age: 18+
Code: NCT05919264·Phase 1, Phase 2·Recruiting·Listed Jun 2023
A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer
for Colorectal Cancer
Sites in Nashville, Memphis +30 more locations
Sponsor: Takeda
Sex: All·Age: 18+
Code: NCT06562543·Phase 4·Recruiting·Listed Aug 2024
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
for Colorectal Cancer
Sites in Nashville +31 more locations
Sponsor: Revolution Medicines, Inc.
Sex: All·Age: 18+
Code: NCT06445062·Phase 1, Phase 2·Recruiting·Listed Jun 2024
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
for Advanced Solid Tumor
Sites in Nashville +30 more locations
Sponsor: PMV Pharmaceuticals, Inc
Sex: All·Age: 12+
Code: NCT04585750·Phase 1, Phase 2·Recruiting·Listed Oct 2020
A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
for Esophageal Squamous Cell Carcinoma
Sites in Nashville +14 more locations
Sponsor: IDEAYA Biosciences
Sex: All·Age: 18+
Code: NCT07503808·Phase 1·Recruiting·Listed Mar 2026
A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors
for Breast Cancer
Sites in Nashville +4 more locations
Sponsor: Jazz Pharmaceuticals
Sex: All·Age: 18+
Code: NCT06695845·Phase 2·Recruiting·Listed Nov 2024
A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors
for Locally Advanced or Metastatic Solid Tumors
Sites in Nashville +9 more locations
Sponsor: ArriVent BioPharma, Inc.
Sex: All·Age: 18+
Code: NCT07066657·Phase 1·Recruiting·Listed Jul 2025
A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
for Colorectal Cancer
Sites in Nashville +21 more locations
Sponsor: AbbVie
Sex: All·Age: 18+
Code: NCT07023289·Phase 2·Recruiting·Listed Jun 2025
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
for Colorectal Neoplasms
Sites in Nashville +20 more locations
Sponsor: Seagen, a wholly owned subsidiary of Pfizer
Sex: All·Age: 18+
Code: NCT06131840·Phase 1·Recruiting·Listed Nov 2023
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
for Non-Small Cell Lung Cancer (NSCLC)
Drug: daraxonrasib
Sites in Nashville +19 more locations
Sponsor: Revolution Medicines, Inc.
Sex: All·Age: 18+
Code: NCT06128551·Phase 1, Phase 2·Recruiting·Listed Nov 2023
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
for Advanced Solid Tumors
Sites in Nashville +9 more locations
Sponsor: Marengo Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT05592626·Phase 1, Phase 2·Recruiting·Listed Oct 2022
A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
for Solid Tumor, Adult
Sites in Nashville +11 more locations
Sponsor: A2 Biotherapeutics Inc.
Sex: All·Age: 18+
Code: NCT06051695·Phase 1, Phase 2·Recruiting·Listed Sep 2023
Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
for Solid Tumor, Adult
Sites in Nashville +12 more locations
Sponsor: A2 Biotherapeutics Inc.
Sex: All·Age: 18+
Code: NCT04981119·Recruiting·Listed Jul 2021
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
for Metastatic Uveal Melanoma
Sites in Nashville +6 more locations
Sponsor: IDEAYA Biosciences
Sex: All·Age: 18+
Code: NCT03947385·Phase 1, Phase 2·Recruiting·Listed May 2019
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
for Pancreatic Ductal Adenocarcinoma
Sites in Nashville +12 more locations
Sponsor: Verastem, Inc.
Sex: All·Age: 18+
Code: NCT07020221·Phase 1, Phase 2·Recruiting·Listed Jun 2025
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
for Head and Neck Squamous Cell Carcinoma
Sites in Nashville +14 more locations
Sponsor: Bicara Therapeutics
Sex: All·Age: 18+
Code: NCT04429542·Phase 1·Recruiting·Listed Jun 2020
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
for Brain Cancer
Sites in Nashville, Memphis +14 more locations
Sponsor: Adela, Inc
Sex: All·Age: 40+·Accepts healthy volunteers
Code: NCT05366881·Recruiting·Listed May 2022
A Phase 1 Study Evaluating DISP-10 in Participants With Advanced Gastrointestinal Cancers
for Colorectal Cancer
Sites in Nashville +2 more locations
Sponsor: Dispatch Biotherapeutics
Sex: All·Age: 18+
Code: NCT07544589·Phase 1·Recruiting·Listed Apr 2026
A Study of JNJ-95437446 in Participants With Advanced-Stage Solid Tumors
for Colorectal Neoplasms
Sites in Nashville +3 more locations
Sponsor: Janssen Research & Development, LLC
Sex: All·Age: 18+
Code: NCT07107230·Phase 1·Recruiting·Listed Aug 2025
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
for Advanced Solid Tumors
Sites in Nashville +14 more locations
Sponsor: Vividion Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06004245·Phase 1·Recruiting·Listed Aug 2023
Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
for Diffuse Astrocytoma, IDH-Mutant
Sites in Nashville +6 more locations
Sponsor: Neonc Technologies, Inc.
Sex: All·Age: 18+
Code: NCT06047379·Phase 1, Phase 2·Recruiting·Listed Sep 2023
CT-95 in Advanced Cancers Associated With Mesothelin Expression
for Mesothelin-Expressing Tumors
Sites in Nashville +8 more locations
Sponsor: Context Therapeutics Inc.
Sex: All·Age: 18+
Code: NCT06756035·Phase 1·Recruiting·Listed Jan 2025
A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Colorectal Cancer
for Colorectal Cancer
Sites in Nashville +8 more locations
Sponsor: Criterium, Inc.
Sex: All·Age: 18+
Code: NCT06992258·Phase 2·Recruiting·Listed May 2025
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
for Cancer
Sites in Nashville +5 more locations
Sponsor: Angiex, Inc.
Sex: All·Age: 18+
Code: NCT06440005·Phase 1·Recruiting·Listed Jun 2024
A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy
for Neuroendocrine Tumors
Sites in Nashville +3 more locations
Sponsor: Chimeric Therapeutics
Sex: All·Age: 18 - 85
Code: NCT06055439·Phase 1, Phase 2·Recruiting·Listed Sep 2023
A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (FRUITFUL)
for Colon Cancer
Sites in Nashville +13 more locations
Sponsor: SCRI Development Innovations, LLC
Sex: All·Age: 18+
Code: NCT07011576·Phase 2·Recruiting·Listed Jun 2025
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
for Non-small Cell Lung Cancer
Sites in Nashville +19 more locations
Sponsor: Institut de Recherches Internationales Servier
Sex: All·Age: 18+
Code: NCT05786924·Phase 1, Phase 2·Recruiting·Listed Mar 2023
Gastrointestinal Biomarkers in Tissue and Biological Fluid Samples From Colorectal Cancer Patients
for Colorectal Cancer
2 locations in Nashville
Sponsor: Vanderbilt University Medical Center
Sex: All·Age: 18+
Code: NCT00899626·Recruiting·Listed May 2009
Preserving Fertility After Colorectal Cancer Study
for Colorectal Cancer
1 location in Nashville
Sponsor: Andreana Holowatyj, PhD, MSCI
Sex: All·Age: 18 - 49
Code: NCT05239338·Recruiting·Listed Feb 2022
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
for Non-small Cell Lung Cancer
Sites in Nashville +17 more locations
Sponsor: AstraZeneca
Sex: All·Age: 18+
Code: NCT06218914·Phase 1·Recruiting·Listed Jan 2024
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
for Endometrial Cancer
Sites in Nashville +10 more locations
Sponsor: AstraZeneca
Sex: All·Age: 18 - 130
Code: NCT05489211·Phase 2·Recruiting·Listed Aug 2022
A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
for Non-small Cell Lung Cancer
Sites in Nashville +13 more locations
Sponsor: AstraZeneca
Sex: All·Age: 18+
Code: NCT05877599·Phase 1·Recruiting·Listed May 2023
Top Research Study Locations in Nashville
Researchers run research studies in Nashville, TN at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Vanderbilt University Medical Center | Colorectal Cancer, Critical Illness, Parkinson Disease | 372 |
| SCRI Oncology Partners | Breast Cancer, Colorectal Cancer, Advanced Solid Tumor | 129 |
| Vanderbilt University/Ingram Cancer Center | Head and Neck Squamous Cell Carcinoma, Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | 81 |
| Sarah Cannon Research Institute | Advanced Solid Tumor, Advanced Solid Tumors, Colorectal Cancer | 62 |
| Vanderbilt University | Breast Cancer, Cardiac Failure, Graft Rejection | 54 |
| Tennessee Oncology | Multiple Myeloma, Breast Cancer, Carcinoma, Non-Small-Cell Lung | 49 |
| Vanderbilt-Ingram Cancer Center | Breast Cancer, Colorectal Cancer, Endometrial Cancer | 36 |
| The Children's Hospital at TriStar Centennial | Malignant Solid Neoplasm, Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia | 27 |
| TriStar Centennial Medical Center | Coronary Artery Disease, Acute Lower Limb Arterial Occlusion, Acute Myeloid Leukemia (AML) | 16 |
| Tennessee Oncology, PLLC | Advanced Solid Tumor, Breast Cancer, Advanced Breast Cancer | 13 |
| Vanderbilt Breast Center at One Hundred Oaks | Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Malignant Solid Neoplasm, Advanced Malignant Solid Neoplasm | 13 |
| Monroe Carell Jr. Children's Hospital at Vanderbilt | Acute Kidney Injury, Acute Myeloid Leukemia, Angelman Syndrome | 12 |
| Tennessee Valley Healthcare System Nashville Campus, Nashville, TN | Cardiovascular Disease, Acute Kidney Injury (AKI), Aging | 10 |
| Ascension Saint Thomas | Coronary Artery Disease, Mitral Regurgitation, Acute or Chronic Coronary Artery Disease | 9 |
| GSK Investigational Site | Neoplasms, Multiple Myeloma, Irritable Bowel Syndrome | 9 |
| Sarah Cannon Research Institute Oncology Partners | Advanced Solid Tumors, Advanced Cancer, Advanced NRAS-Mutant Melanoma | 9 |
| Henry-Joyce Cancer Clinic | Colorectal Neoplasms, Breast Cancer, Colonic Diseases | 8 |
| Tennessee Retina, PC | Geographic Atrophy, Neovascular Age-Related Macular Degeneration (nAMD), Age-related Macular Degeneration (AMD) | 8 |
| Vanderbilt Eye Institute | Geographic Atrophy (GA), Macular Edema Secondary to Inflammation, Age - Related Macular Degeneration (AMD) | 8 |
| Centennial Medical Center | Cardiovascular Diseases, Coronary Artery Disease, Heart Failure | 7 |
| Vanderbilt Medical Center | Acinar Cell Carcinoma, Advanced Cancer, Alzheimer Disease | 7 |
| Autonomic Dysfunction Center/ Vanderbilt University Medical Center | Autonomic Failure, Multiple System Atrophy, Pure Autonomic Failure | 6 |
| Meharry Medical College | ARDS, Cardiovascular Diseases, Cognitive Impairment, Mild | 6 |
| Sarah Cannon Research Institute (SCRI) Oncology Partners | Advanced Solid Tumor, Metastatic Solid Tumor, Ovarian Cancer | 6 |
| Sarah Cannon Research Institute - Pharmacy | Gastroesophageal Junction Adenocarcinoma, Advanced Cancer, Advanced Colorectal Cancer (Part 1) | 6 |
Active & Upcoming Studies in Nashville (2026)
Recruiting trials in Nashville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (561 active studies)
- Pilot Study of Casdatifan-Treated Refractory Renal Cell Carcinoma · EARLY_Phase 1 · Vanderbilt-Ingram Cancer Center
- A Study to Evaluate Adverse Events and Change in Disease Activity With Injected Etentamig Plus Oral Pomalidomide Versus Standard Therapies in Adults With Relapsed or Refractory Multiple Myeloma · Phase 3 · AbbVie
Cardiovascular (90 active studies)
- Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways · Peerbridge Health, Inc
- A Study of VARIPULSE Catheter in Participants With Persistent Atrial Fibrillation Undergoing Pulmonary Vein and Superior Vena Cava Isolation · Biosense Webster, Inc.
Neurology & pain (61 active studies)
- The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery · Phase 4 · Vanderbilt University Medical Center
- 2-Hydroxybenzylamine (2-HOBA) Study in Early Alzheimer's Patients · Phase 1, Phase 2 · MTI Biotech Inc
Diabetes & metabolic (50 active studies)
- HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide · Phase 2 · Vanderbilt University Medical Center
- Transition to Ambulatory Bariatric Surgery (TABS) Trial · Vanderbilt University Medical Center
Eye & vision (21 active studies)
- A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration · Phase 3 · Amgen
- A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated · Phase 1, Phase 2 · Boehringer Ingelheim
Mental health & behavior (16 active studies)
- Cognitive Enhancement in Recurrent Depression (The COG-D-R Study) · Vanderbilt University Medical Center
- GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV · Phase 2 · Vanderbilt University Medical Center
Vaccines (8 active studies)
- A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of Age · Phase 3 · GlaxoSmithKline
- Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS · Phase 2 · Vanderbilt University Medical Center
HIV / STI (7 active studies)
- Phase 1 Study of CH505 HIV Vaccine Nanoparticles and mRNA Boosters in Healthy Adults · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV · Phase 2 · Vanderbilt University Medical Center
Pediatric (7 active studies)
- Neonatal Platelet Transfusion Threshold Trial · NICHD Neonatal Research Network
- Safety Study to Evaluate the Occurrence of EFAD in Pediatric Patients With PNAC Who Require More Than Eight Weeks of Omegaven Treatment · Fresenius Kabi
Common conditions studied in Nashville
- Breast Cancer (43 active studies)
- Colorectal Cancer (32 active studies)
- Advanced Solid Tumor (30 active studies)
- Ovarian Cancer (28 active studies)
- Multiple Myeloma (24 active studies)
- Prostate Cancer (24 active studies)
Leading research sponsors in Nashville
- Vanderbilt University Medical Center
- AstraZeneca
- Vanderbilt-Ingram Cancer Center
- National Cancer Institute (NCI)
- Merck Sharp & Dohme LLC
Frequently asked questions
How many paid clinical trials are currently recruiting in Nashville?
There are approximately 1,355 recruiting clinical trials in Nashville, Tennessee listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Nashville pay participants?
Most recruiting trials in Nashville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Nashville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Nashville?
The most common conditions under active study in Nashville include Breast Cancer (43), Colorectal Cancer (32), Advanced Solid Tumor (30), Ovarian Cancer (28), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Nashville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Nashville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Nashville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Nashville?
Recruiting research sites in Nashville include Vanderbilt University Medical Center, SCRI Oncology Partners, Vanderbilt University/Ingram Cancer Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Nashville right now?
The largest active categories in Nashville are Cancer & tumors (561), Cardiovascular (90), Neurology & pain (61). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
Browse more clinical trials
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