Metastatic breast cancer Clinical Trials in Nashville, TN
As of September 2026, 19 paid clinical trials are recruiting for Metastatic breast cancer in Nashville, Tennessee. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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19 clinical trials for Metastatic breast cancer
·Clear filters·Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer
A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer
A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors
A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer
Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer
First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer
A Study of JNJ-101684362 (HLD-0117) in Patients With Metastatic Breast Cancer
Phase 1/2 Study to Evaluate EP0062 as Monotherapy and in Combination in Patients With Advanced or Metastatic AR+/HER-2-/ER+ Breast Cancer
Phase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors
A Study of BTX-A51 in People With Advanced Solid Tumor and Breast Cancer
TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd
Gene Signatures to Guide HR+MBC Therapy in a Diverse Cohort
Study to Evaluate the Safety and Tolerability of Camizestrant in Combination With Atirmociclib in Women With Advanced Breast Cancer
Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
Top Research Study Locations in Nashville
Researchers run research studies in Nashville, TN at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Vanderbilt University Medical Center | Colorectal Cancer, Critical Illness, Parkinson Disease | 374 |
| SCRI Oncology Partners | Breast Cancer, Colorectal Cancer, Advanced Solid Tumor | 125 |
| Vanderbilt University/Ingram Cancer Center | Stage IV Colorectal Cancer AJCC v8, Head and Neck Squamous Cell Carcinoma, Malignant Solid Neoplasm | 81 |
| Sarah Cannon Research Institute | Advanced Solid Tumor, Prostate Cancer, Advanced Solid Tumors | 63 |
| Vanderbilt University | Autoimmune Diseases, Breast Cancer, Cardiac Failure | 53 |
| Tennessee Oncology | Multiple Myeloma, Breast Cancer, Carcinoma, Non-Small-Cell Lung | 50 |
| Vanderbilt-Ingram Cancer Center | Breast Cancer, Colorectal Cancer, Endometrial Cancer | 36 |
| The Children's Hospital at TriStar Centennial | Malignant Solid Neoplasm, Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia | 26 |
| Monroe Carell Jr. Children's Hospital at Vanderbilt | Acute Kidney Injury, Acute Myeloid Leukemia, Angelman Syndrome | 13 |
| Tennessee Oncology, PLLC | Advanced Solid Tumor, Breast Cancer, Advanced Breast Cancer | 13 |
| TriStar Centennial Medical Center | Coronary Artery Disease, Acute Lower Limb Arterial Occlusion, Acute Myeloid Leukemia (AML) | 13 |
| Vanderbilt Breast Center at One Hundred Oaks | Metastatic Malignant Solid Neoplasm, Advanced Malignant Solid Neoplasm, Anatomic Stage III Breast Cancer AJCC v8 | 13 |
| Sarah Cannon Research Institute Oncology Partners | Advanced Cancer, Advanced NRAS-Mutant Melanoma, Advanced NRAS-Mutant Solid Tumors | 10 |
| Tennessee Valley Healthcare System Nashville Campus, Nashville, TN | Cardiovascular Disease, Acute Kidney Injury (AKI), Aging | 10 |
| Ascension Saint Thomas | Coronary Artery Disease, Mitral Regurgitation, Acute or Chronic Coronary Artery Disease | 9 |
| GSK Investigational Site | Neoplasms, Multiple Myeloma, Irritable Bowel Syndrome | 9 |
| Henry-Joyce Cancer Clinic | Colorectal Neoplasms, Advanced Renal Cell Carcinoma, Advanced or Metastatic Renal Cell Carcinoma | 8 |
| Vanderbilt Eye Institute | Geographic Atrophy (GA), Macular Edema Secondary to Inflammation, Age - Related Macular Degeneration (AMD) | 8 |
| Meharry Medical College | ARDS, Cardiovascular Diseases, Cognitive Impairment, Mild | 7 |
| Tennessee Retina, PC | Neovascular Age-Related Macular Degeneration (nAMD), Age-related Macular Degeneration (AMD), Choroidal Melanoma | 7 |
| Vanderbilt Medical Center | Acinar Cell Carcinoma, Advanced Cancer, Alzheimer Disease | 7 |
| Autonomic Dysfunction Center/ Vanderbilt University Medical Center | Autonomic Failure, Multiple System Atrophy, Pure Autonomic Failure | 6 |
| Centennial Medical Center | Cardiovascular Diseases, Coronary Artery Disease, Heart Failure | 6 |
| Sarah Cannon Research Institute (SCRI) Oncology Partners | Advanced Solid Tumor, Metastatic Solid Tumor, Ovarian Cancer | 6 |
| Tennessee Oncology, PLLC - Investigational Drug Services | Advanced/Metastatic Urothelial Cancer, Cancer of the Prostate, Hormone Sensitive Prostate Cancer | 6 |
Active & Upcoming Studies in Nashville (2026)
Recruiting trials in Nashville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (553 active studies)
- Pilot Study of Casdatifan-Treated Refractory Renal Cell Carcinoma · EARLY_Phase 1 · Vanderbilt-Ingram Cancer Center
- PhII Study of Toripalimab Followed by Definitive CRT & Adjuvant Toripalimab in Locally Advanced ESCC · Phase 2 · Vanderbilt-Ingram Cancer Center
Cardiovascular (91 active studies)
Neurology & pain (63 active studies)
- Cholinergic Deep Brain Stimulation for Alzheimer's Disease · Vanderbilt University Medical Center
- Alzheimer's Tau Platform: Regimen A - AADvac1 · Phase 2 · Paul S. Aisen
Diabetes & metabolic (50 active studies)
- HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide · Phase 2 · Vanderbilt University Medical Center
- Transition to Ambulatory Bariatric Surgery (TABS) Trial · Vanderbilt University Medical Center
Eye & vision (18 active studies)
- A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration · Phase 3 · Amgen
- A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated · Phase 1, Phase 2 · Boehringer Ingelheim
Mental health & behavior (15 active studies)
- Cognitive Enhancement in Recurrent Depression (The COG-D-R Study) · Vanderbilt University Medical Center
- GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV · Phase 2 · Vanderbilt University Medical Center
HIV / STI (8 active studies)
- Phase 1 Study of CH505 HIV Vaccine Nanoparticles and mRNA Boosters in Healthy Adults · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV · Phase 2 · Vanderbilt University Medical Center
Vaccines (7 active studies)
- A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of Age · Phase 3 · GlaxoSmithKline
- Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS · Phase 2 · Vanderbilt University Medical Center
Pediatric (7 active studies)
- Neonatal Platelet Transfusion Threshold Trial · NICHD Neonatal Research Network
- Safety Study to Evaluate the Occurrence of EFAD in Pediatric Patients With PNAC Who Require More Than Eight Weeks of Omegaven Treatment · Fresenius Kabi
Common conditions studied in Nashville
- Breast Cancer (40 active studies)
- Colorectal Cancer (33 active studies)
- Advanced Solid Tumor (30 active studies)
- Ovarian Cancer (29 active studies)
- Prostate Cancer (25 active studies)
- Endometrial Cancer (23 active studies)
Leading research sponsors in Nashville
- Vanderbilt University Medical Center
- AstraZeneca
- Vanderbilt-Ingram Cancer Center
- National Cancer Institute (NCI)
- Eli Lilly and Company
Frequently asked questions
How many paid clinical trials are currently recruiting in Nashville?
There are approximately 1,346 recruiting clinical trials in Nashville, Tennessee listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Nashville pay participants?
Most recruiting trials in Nashville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Nashville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Nashville?
The most common conditions under active study in Nashville include Breast Cancer (40), Colorectal Cancer (33), Advanced Solid Tumor (30), Ovarian Cancer (29), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Nashville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Nashville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Nashville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Nashville?
Recruiting research sites in Nashville include Vanderbilt University Medical Center, SCRI Oncology Partners, Vanderbilt University/Ingram Cancer Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Nashville right now?
The largest active categories in Nashville are Cancer & tumors (553), Cardiovascular (91), Neurology & pain (63). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.