Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Esophagus

for Esophageal Stricture

Sites in Chapel Hill +33 more locations

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561114·Phase 3·Recruiting·Listed Sep 2022

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Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Bowel

for Bowel

Sites in Chapel Hill +32 more locations

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561127·Phase 3·Recruiting·Listed Sep 2022

Apply to this trial

CAR-T Long Term Follow Up (LTFU) Study

for Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program

Sites in Durham +40 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 0 - 100

Code: NCT02445222·Phase 3·Recruiting·Listed May 2015

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Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib

for Myelofibrosis

Drug: Ruxolitinib

Sites in Durham, Winston-Salem +56 more locations

Sponsor: Kartos Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06479135·Phase 3·Recruiting·Listed Jun 2024

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Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)

for Spinal Muscular Atrophy (SMA)

Sites in Durham +41 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: All ages

Code: NCT04174157·Recruiting·Listed Nov 2019

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A Phase 2 Study of Vosoritide in Children With Idiopathic Short Stature

for Idiopathic Short Stature

Drug: Vosoritide

Sites in Chapel Hill +30 more locations

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 3 - 11

Code: NCT06382155·Phase 2·Recruiting·Listed Apr 2024

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SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

for Cancer, Metastatic

Sites in Chapel Hill, Winston-Salem +65 more locations

Sponsor: Massive Bio, Inc.

Sex: All·Age: All ages

Code: NCT03452774·Recruiting·Listed Mar 2018

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A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet in Women With Uterine Fibroids or Endometriosis

for Uterine Fibroids

Drug: Relugolix

Sites in Durham, Winston-Salem +118 more locations

Sponsor: Sumitomo Pharma Switzerland GmbH

Sex: Female·Age: 18 - 50

Code: NCT05862272·Phase 3·Recruiting·Listed May 2023

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Efficacy and Safety Study of Halneuron in the Treatment of Chemotherapy-Induced Neuropathic Pain

for Chemotherapy Induced Neuropathic Pain

Sites in Winston-Salem +24 more locations

Sponsor: Dogwood Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06848348·Phase 2·Recruiting·Listed Feb 2025

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CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)

for Relapsed Hematologic Malignancy

Drug: Emavusertib

Sites in Durham +17 more locations

Sponsor: Curis, Inc.

Sex: All·Age: 18+

Code: NCT03328078·Phase 1, Phase 2·Recruiting·Listed Nov 2017

Apply to this trial

Prospective Study to Assess a Diagnostic Aid for Cancer

for Cancer

Sites in Wilmington +34 more locations

Sponsor: Harbinger Health

Sex: All·Age: 45+

Code: NCT07046260·Recruiting·Listed Jul 2025

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Efficacy and Safety of Extended TARPEYO® Treatment Beyond 9 Months in Adult Patients With Primary IgA Nephropathy

for IgA Nephropathy

Sites in Raleigh +36 more locations

Sponsor: Calliditas Therapeutics AB

Sex: All·Age: 18+

Code: NCT06712407·Phase 4·Recruiting·Listed Dec 2024

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Fontan Udenafil Exercise Longitudinal Assessment Trial - 2

for Single Ventricle Heart Disease

Sites in Durham, Charlotte +35 more locations

Sponsor: Mezzion Pharma Co. Ltd

Sex: All·Age: 12 - 18

Code: NCT05918211·Phase 3·Recruiting·Listed Jun 2023

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NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

for Aortic Dissection

Sites in Chapel Hill, Charlotte +22 more locations

Sponsor: Endospan Ltd.

Sex: All·Age: 18+

Code: NCT04471909·Recruiting·Listed Jul 2020

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Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

for Neurotrophic Keratopathy

Sites in Durham +23 more locations

Sponsor: ReGenTree, LLC

Sex: All·Age: 18+

Code: NCT05555589·Phase 3·Recruiting·Listed Sep 2022

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A Study of CREXONT (Carbidopa and Levodopa) Extended-Release Capsules in Participants With Parkinson's Disease

for Parkinson Disease

Sites in Winston-Salem +26 more locations

Sponsor: Impax Laboratories, LLC

Sex: All·Age: 18+

Code: NCT06765668·Phase 4·Recruiting·Listed Jan 2025

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Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

for Lung Cancer Diagnosis

Sites in Raleigh +35 more locations

Sponsor: Freenome Holdings Inc.

Sex: All·Age: 50+

Code: NCT06122077·Recruiting·Listed Nov 2023

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To Evaluate the Safety and Efficacy of MANP in Subjects With Difficult to Control/ Resistant Hypertension

for Difficult to Control Hypertension

Sites in Monroe, Smithfield +24 more locations

Sponsor: E-Star BioTech, LLC

Sex: All·Age: 18 - 80

Code: NCT06343298·Phase 2·Recruiting·Listed Apr 2024

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AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

for Heart Failure

Sites in Greensboro, Asheville +35 more locations

Sponsor: Cordio Medical

Sex: All·Age: 22+

Code: NCT06378632·Recruiting·Listed Apr 2024

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MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions

for In-Stent Restenosis

Sites in Raleigh +27 more locations

Sponsor: Concept Medical Inc.

Sex: All·Age: 18 - 110

Code: NCT05908331·Recruiting·Listed Jun 2023

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C-Brace Prospective Registry

for Pareses

Sites in Wilmington, Lenoir +35 more locations

Sponsor: Otto Bock Healthcare Products GmbH

Sex: All·Age: All ages

Code: NCT04640584·Recruiting·Listed Nov 2020

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Impella RP Flex with Smart Assist

for Right Ventricular (RV) Dysfunction

Sites in Winston-Salem, Wilmington +29 more locations

Sponsor: Abiomed Inc.

Sex: All·Age: All ages

Code: NCT06637644·Recruiting·Listed Oct 2024

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To Evaluate the Effect of EXPD-101/FXS7553 Compared With Placebo in Patients With COPD Over 52 Weeks of Treatment

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Shelby +19 more locations

Sponsor: Expedition Therapeutics, Inc

Sex: All·Age: 40 - 85

Code: NCT07684820·Phase 2·Recruiting·Listed Jul 2026

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A Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation

for AML

Sites in Chapel Hill +25 more locations

Sponsor: TScan Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07702578·Phase 3·Recruiting·Listed Jul 2026

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A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic Cancer

for Pancreatic Ductal Adenocarcinoma (PDAC)

Sites in Chapel Hill +23 more locations

Sponsor: Verastem, Inc.

Sex: All·Age: 18+

Code: NCT07644559·Phase 2·Recruiting·Listed Jun 2026

Apply to this trial

A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Narcolepsy

for EDS

Sites in Huntersville, Gastonia +49 more locations

Sponsor: Harmony Biosciences Management, Inc.

Sex: All·Age: 18+

Code: NCT07675135·Phase 3·Recruiting·Listed Jun 2026

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Study of EVO756 in Adults With Migraine

for Migraine

Sites in Raleigh, Asheville +24 more locations

Sponsor: Evommune, Inc.

Sex: All·Age: 18 - 64

Code: NCT07616128·Phase 2·Recruiting·Listed Jun 2026

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Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD

for Rhinovirus Infection

Sites in Kings Mountain +33 more locations

Sponsor: Altesa Biosciences, Inc.

Sex: All·Age: 40 - 85

Code: NCT07610395·Phase 2·Recruiting·Listed May 2026

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A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

for Obesity

Sites in Wilmington, Greensboro +32 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07595549·Phase 3·Recruiting·Listed May 2026

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A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity

for Obesity

Drug: NNC0662-0419

Sites in Wilmington +23 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07639021·Phase 2·Recruiting·Listed Jun 2026

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Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

for Pancreatic Cancer

Drug: Atebimetinib

Sites in Pinehurst +38 more locations

Sponsor: Immuneering Corporation

Sex: All·Age: 18+

Code: NCT07562152·Phase 3·Recruiting·Listed May 2026

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PRESERVE: LUPKYNIS in Combination With Belimumab, Obinutuzumab or Anifrolumab in Patients With Lupus Nephritis

for Lupus Nephritis

Sites in Charlotte +26 more locations

Sponsor: Aurinia Pharmaceuticals Inc.

Sex: All·Age: 18 - 75

Code: NCT07611214·Phase 4·Recruiting·Listed May 2026

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A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

for Depressive Disorder, Major

Drug: Seltorexant

Sites in Cary +30 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT07573176·Phase 3·Recruiting·Listed May 2026

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Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events

for Obesity

Sites in Wilmington, Monroe +9 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07607587·Phase 1·Recruiting·Listed May 2026

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A Phase 2 Trial of Dotinurad in Xanthine Oxidase Inhibitor (XOI) Intolerant/Uricase Failure Gout Participants

for Gout

Drug: Dotinurad

Sites in Charlotte, Shelby +36 more locations

Sponsor: Crystalys Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07535034·Phase 2·Recruiting·Listed Apr 2026

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A Clinical Study Evaluating Licaminlimab for Dry Eye Disease

for Dry Eye Disease (DED)

Sites in Shelby, Garner +10 more locations

Sponsor: Oculis

Sex: All·Age: 18+

Code: NCT07548632·Phase 2, Phase 3·Recruiting·Listed Apr 2026

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Study to Evaluate HM15275 in Subjects With Type 2 Diabetes Mellitus

for Type 2 Diabetes Mellitus

Sites in Morehead City +14 more locations

Sponsor: Hanmi Pharmaceutical Company Limited

Sex: All·Age: 18 - 75

Code: NCT07527650·Phase 2·Recruiting·Listed Apr 2026

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A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation

for Atrial Fibrillation

Sites in Raleigh +29 more locations

Sponsor: Biosense Webster, Inc.

Sex: All·Age: 18 - 80

Code: NCT07523750·Recruiting·Listed Apr 2026

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Evaluation of the Fully Closed Loop Omnipod® System in Type 2 Diabetes

for Type 2 Diabetes Mellitus

Sites in Wilmington, Asheville +24 more locations

Sponsor: Insulet Corporation

Sex: All·Age: 18 - 75

Code: NCT07521475·Recruiting·Listed Apr 2026

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AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

for Obesity

Drug: NNC0487-0111

Sites in Statesville +18 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07509307·Phase 3·Recruiting·Listed Apr 2026

Apply to this trial