Paid Clinical Trials in North Carolina

North Carolina has 2,939 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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2,939 clinical trials

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A Trial of TAK-861 for the Treatment of Narcolepsy With Cataplexy

for Narcolepsy Type 1 (NT1)

11 locations incl. Redwood City

Sponsor: Takeda

Sex: All·Age: 16 - 70

Code: NCT07363720·Phase 3·Recruiting

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Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)

for Hepatitis

Drug: Larsucosterol

48 locations incl. Birmingham

Sponsor: Bausch Health Americas, Inc.

Sex: All·Age: 18+

Code: NCT07428538·Phase 3·Recruiting

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Double-blind, Randomized Clinical Trial Evaluating the Efficacy and Safety of Vormatrigine in Adults With Focal Seizures

for Focal Epilepsy

7 locations incl. Miami

Sponsor: Praxis Precision Medicines

Sex: All·Age: 18 - 85

Code: NCT07505004·Phase 3·Recruiting

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Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia

for Head and Neck Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07278557·Phase 2·Recruiting

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A Study of KT-621 Administered Orally to Adult Participants With Moderate to Severe Eosinophilic Asthma

for Eosinophilic Asthma

20 locations incl. Long Beach

Sponsor: Kymera Therapeutics, Inc.

Sex: All·Age: 18 - 75

Code: NCT07323654·Phase 2·Recruiting

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Intestinal Microbiome Transplant in ALS

for Amyotrophic Lateral Sclerosis ALS

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07017946·Phase 1, Phase 2·Recruiting

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Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

for Advanced Endometrial Carcinoma

Drug: Bevacizumab

212 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07198074·Phase 3·Recruiting

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A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma

for Squamous Cell Carcinoma of Head and Neck

8 locations incl. Birmingham

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 18 - 74

Code: NCT07219212·Phase 1·Recruiting

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A Long-Term Extension Study of IMVT-1402 in Adult Participants With Graves' Disease (GD)

for Graves' Disease

Drug: IMVT-1402

89 locations incl. Phoenix

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18+

Code: NCT07286006·Phase 2·Enrolling By Invitation

ONC-MM-2407: The Effect of Virtual Reality Headsets on Pain and Anxiety in the Peri and Post Bone Marrow Biopsy Period

for Hematologic Malignancy

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07203534·Recruiting

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Drug-Drug Interaction Study of ABP-671 in Gout Patients

for Gout Chronic

1 location in Cary

Sponsor: Atom Therapeutics Co., Ltd

Sex: All·Age: 18 - 75

Code: NCT07367971·Phase 1·Recruiting

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Inobrodib, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma Refractory

12 locations incl. San Francisco

Sponsor: CellCentric Ltd.

Sex: All·Age: 18+

Code: NCT07096778·Phase 2·Recruiting

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A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Duvakitug

14 locations incl. Colorado Springs

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184944·Phase 3·Recruiting

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Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis

for Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis

Drug: Vamifeport

18 locations incl. Gilbert

Sponsor: CSL Behring

Sex: All·Age: 18+

Code: NCT07332091·Phase 2·Recruiting

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Interscalene vs Phrenic-sparing Blocks in Obesity and Effect of Maximum Inspiratory Pressure

for Shoulder Surgery

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07216820·Recruiting

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Improving Outcomes in Early Menopause After Cancer

for Early Menopause

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 44

Code: NCT06982677·Recruiting

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A Study of DB-1324 in Advanced/Metastatic Gastrointestinal Tumors

for Gastrointestinal Cancer

4 locations incl. Port Saint Lucie

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT07263594·Phase 1, Phase 2·Recruiting

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Effects of Muscle Cooling on Motor Unit Firing of the Quadriceps

for Healthy

1 location in Winston-Salem

Sponsor: Wake Forest University

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT07381920·Recruiting

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Nutrition Awareness Among Women With Non-Metastatic Breast Cancer

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT07389967·Recruiting

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Improving Hypertension Control in Rheumatoid Arthritis

for Hypertension

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT05760898·Recruiting

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A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis

Drug: Duvakitug

26 locations incl. Tucson

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07185009·Phase 3·Recruiting

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Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations

for Non-small Cell Lung Cancer

29 locations incl. Fresno

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07195695·Phase 3·Recruiting

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A Study to Test DSP107 in Combination With Atezolizumab in Comparison With Fruquintinib as a New Treatment for Colorectal Cancer.

for Colorectal Cancer

Drug: Atezolizumab

6 locations incl. Aurora

Sponsor: Kahr Bio Australia Pty Ltd

Sex: All·Age: 18+

Code: NCT07235293·Phase 2·Recruiting

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Development of a Pain Control Options Menu for IUD Insertion

for IUD Insertion Pain

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 50

Code: NCT07278804·Recruiting

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Vital Coach: A Study of Resiliency in Medical Students

for Burnout

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07342673·Recruiting

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A Study of Revumenib and Mezigdomide in People With Leukemia

for Leukemia

Drug: Mezigdomide

10 locations incl. Duarte

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 12+

Code: NCT07356154·Phase 1, Phase 2·Recruiting

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Digoxin Medulloblastoma Study

for Medulloblastoma

15 locations incl. Birmingham

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 12 Months - 30

Code: NCT06701812·Phase 2·Recruiting

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Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network, STOP-VTE Study

for Malignant Digestive System Neoplasm

58 locations incl. Fort Smith

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07215624·Recruiting

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Horizon 360 Protocol for the Treatment of Paroxysmal Atrial Fibrillation With the Sphere-360™ Catheter and Affera™ Mapping and Ablation System (Horizon 360)

for Paroxysmal AF

22 locations incl. Jonesboro

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18 - 80

Code: NCT07308847·Recruiting

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A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis

for Arthritis, Psoriatic

16 locations incl. Searcy

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07321873·Phase 2·Recruiting

Apply to this trial

Mindfulness Intervention for Sleep Disturbance and Symptom Management in Hematologic Cancer Patients During and After Inpatient Treatment

for Hematologic Malignancy

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06532773·Recruiting

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Allopregnanolone (Zuranolone) in Post-stroke Depression

for Post Stroke Depression

Drug: Zuranolone

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 21 - 65

Code: NCT06759558·Phase 2·Recruiting

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Evaluation of Flexible Conductive Hearing Aids

for Conductive Hearing Loss

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 6 Months - 80·Accepts healthy volunteers

Code: NCT07222202·Recruiting

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Understanding Needs of Older Patients Prior to Starting Cancer Treatment

for Hematopoietic and Lymphatic System Neoplasm

24 locations incl. Tuscaloosa

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07225920·Enrolling By Invitation

Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis

for Multiple Sclerosis

Drug: Frexalimab

21 locations incl. Cullman

Sponsor: Sanofi

Sex: All·Age: 18 - 60

Code: NCT07325292·Phase 3·Recruiting

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Pyloric Sphincter Abnormalities in Patients With Gastroparesis Symptoms

for Gastroparesis

5 locations incl. Scottsdale

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT04661215·Recruiting

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Duke Customized Aortic Aneurysm Repair With Endovascular Stent-grafts - Duke CARES Trial

for Aortic Disorders

1 location in Durham

Sponsor: Chandler Long, MD

Sex: All·Age: 18+

Code: NCT07064460·Recruiting

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TulmiSTAR-02: A Phase I/II Open-label Study of Tulmimetostat in Combination With Darolutamide vs. Darolutamide, and Tulmimetostat With Abiraterone in Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

for Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)

Drug: Tulmimetostat

8 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: Male·Age: 18+

Code: NCT07190300·Phase 1, Phase 2·Recruiting

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Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using Long-Acting Injectable PrEP

for HIV Prevention

1 location in Durham

Sponsor: Duke University

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT07218211·Phase 4·Recruiting

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RESTORE: Comparing Two Approaches to Repeat TT Surgery Performed by Integrated Eye Care Workers (IECWs)

for Trachoma

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07322302·Recruiting

Apply to this trial