Paid Clinical Trials in North Carolina

North Carolina has 2,939 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

2,939 clinical trials

↓ Download CSV

A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis

for CKD

19 locations incl. Chula Vista

Sponsor: Renibus Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07355062·Phase 3·Recruiting

Apply to this trial

Royal Ancient Oats™ Study

for Healthy Participants

1 location in Kannapolis

Sponsor: Standard Process Inc.

Sex: All·Age: 35 - 65·Accepts healthy volunteers

Code: NCT07371598·Recruiting

Apply to this trial

A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

for Chronic Idiopathic Constipation (CIC)

Drug: Tenapanor

109 locations incl. Foley

Sponsor: Ardelyx

Sex: All·Age: 18 - 80

Code: NCT07382167·Phase 3·Recruiting

Apply to this trial

A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy

for Large B-cell Lymphoma

38 locations incl. Gilbert

Sponsor: Lyell Immunopharma, Inc.

Sex: All·Age: 18+

Code: NCT07188558·Phase 3·Recruiting

Apply to this trial

Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes

for Obesity With Diabetes

34 locations incl. Cullman

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07284901·Phase 3·Recruiting

Apply to this trial

Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression

for Acute Lymphoblastic Leukaemia

6 locations incl. Decatur

Sponsor: AstraZeneca

Sex: All·Age: 16+

Code: NCT07155226·Phase 1, Phase 2·Recruiting

Apply to this trial

Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease

for Diabetic Kidney Disease (DKD)

51 locations incl. Huntsville

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18 - 80

Code: NCT07271186·Phase 2·Recruiting

Apply to this trial

A Study of Buntanetap in Participants With PD

for Parkinson's Disease (PD)

27 locations incl. Birmingham

Sponsor: Annovis Bio Inc.

Sex: All·Age: 40 - 85

Code: NCT07284784·Phase 2, Phase 3·Recruiting

Apply to this trial

A Study of AZD0120 in Autoimmune Diseases

for Systemic Sclerosis

8 locations incl. Tucson

Sponsor: AstraZeneca

Sex: All·Age: 18 - 75

Code: NCT07295847·Phase 1·Recruiting

Apply to this trial

A Study of Migalastat in Pediatric Subjects (2 to <12 Yrs) With Fabry Disease and Amenable GLA Variants

for Fabry Disease

6 locations incl. Atlanta

Sponsor: Amicus Therapeutics

Sex: All·Age: 2 - 11

Code: NCT06904261·Phase 3·Recruiting

Apply to this trial

A Study to Assess A Change in Disease Activity and Adverse Events of Intravenous Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Adult Participants With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant

for Multiple Myeloma

Drug: Daratumumab

17 locations incl. Scottsdale

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07095452·Phase 2, Phase 3·Recruiting

Apply to this trial

SafeHeal Colovac Anastomosis Protection Device Evaluation Pivotal Study

for Colorectal Cancer

12 locations incl. Los Angeles

Sponsor: SafeHeal Inc

Sex: All·Age: 22+

Code: NCT07116668·Enrolling By Invitation

Lead Evaluation for Defibrillation and Reliability Post Approval Study

for Tachyarrhythmia

46 locations incl. Birmingham

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT07005232·Enrolling By Invitation

The ArtixASCEND Study

for Acute Lower Limb Arterial Occlusion

14 locations incl. New Haven

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT07135895·Recruiting

Apply to this trial

Assessing and Addressing Health-Related Social Needs Among Families of Children With Cancer

for Childhood Cancers

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07278414·Recruiting

Apply to this trial

Sensory Spinal Cord Stimulation

for Pain Management

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 85

Code: NCT07095036·Recruiting

Apply to this trial

Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 2

for Aging

4 locations incl. Derby

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07166861·Recruiting

Apply to this trial

A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

for Sickle Cell Disease

7 locations incl. Birmingham

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT07187973·Phase 1·Recruiting

Apply to this trial

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

for Advanced Non-Small Cell Lung Cancer

Drug: PF-08634404

184 locations incl. Bullhead City

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07222566·Phase 3·Recruiting

Apply to this trial

Low Energy Availability and Hypertension in Division I HBCU Athletes

for Vascular Stiffness

1 location in Greensboro

Sponsor: North Carolina Agriculture & Technical State University

Sex: All·Age: 18 - 26·Accepts healthy volunteers

Code: NCT07583940·Recruiting

Apply to this trial

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

for Major Depressive Disorder

32 locations incl. Phoenix

Sponsor: Syndeio Biosciences, Inc

Sex: All·Age: 18 - 64

Code: NCT07115329·Phase 2·Recruiting

Apply to this trial

Comparative Efficacy of Nipocalimab and Efgartigimod in Participants With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

11 locations incl. Fullerton

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT07217587·Phase 3·Recruiting

Apply to this trial

A Study to Learn About the Effects of Felzartamab Infusions in Adults With Kidney Transplants Who Have Late Isolated Microvascular Inflammation

for Microvascular Inflammation

18 locations incl. Loma Linda

Sponsor: Biogen

Sex: All·Age: 18 - 74

Code: NCT07219043·Phase 2·Recruiting

Apply to this trial

Beeline: A Phase 3 Study in GRIN-related Neurodevelopmental Disorder

for GRIN-related Neurodevelopmental Disorder

17 locations incl. Los Angeles

Sponsor: GRIN Therapeutics, Inc.

Sex: All·Age: 1 Month - 18

Code: NCT07224581·Phase 3·Recruiting

Apply to this trial

A Study of a Decision Tool for People Considering Breast Reconstruction Surgery

for Breast Cancer

8 locations incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07335354·Recruiting

Apply to this trial

A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

for Metastatic Non-small Cell Lung Cancer With MTAP Deletion

Drug: Navlimetostat

42 locations incl. Anchorage

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07063745·Phase 2, Phase 3·Recruiting

Apply to this trial

Yoga for Treatment of Overactive Bladder in Pediatric Patients

for Overactive Bladder

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 8 - 18

Code: NCT05895045·Recruiting

Apply to this trial

Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery

for Breast Cancer

4 locations incl. Bethesda

Sponsor: University Hospital, Basel, Switzerland

Sex: All·Age: 18+

Code: NCT07140172·Recruiting

Apply to this trial

Supraglottic Airway for Resuscitation Trial

for Neonatal Resuscitation

30 locations incl. Birmingham

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 Days+

Code: NCT07150923·Recruiting

Apply to this trial

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

for Untreated, Unresectable, or Metastatic Colorectal Cancer

Drug: Bevacizumab

49 locations incl. Tucson

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07221357·Phase 2, Phase 3·Recruiting

Apply to this trial

Hyperangulated Versus Standard Geometry Laryngoscope Blade Trial

for Acute Respiratory Failure

16 locations incl. Los Angeles

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07223762·Enrolling By Invitation

Role of Alpha-to-beta Cell Communication to Adapt Insulin Secretion to Insulin Resistance.

for Diabetes (DM)

1 location in Durham

Sponsor: David D'Alessio, M.D.

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07224334·Phase 1·Recruiting

Apply to this trial

Efficacy and Safety of KAI-9531 Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

for Obesity

Drug: Semaglutide

26 locations incl. Glendale

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07284979·Phase 3·Recruiting

Apply to this trial

Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections

for Colorectal Anastomosis

9 locations incl. New Haven

Sponsor: Medtronic - MITG

Sex: All·Age: 18+

Code: NCT07351071·Recruiting

Apply to this trial

Optimizing Pain Treatment in Children On Mechanical Ventilation

for Mechanical Ventilation

15 locations incl. Little Rock

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 2 Months - 17

Code: NCT06994442·Phase 3·Recruiting

Apply to this trial

A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis

for Atopic Dermatitis

Drug: Tapinarof

37 locations incl. Birmingham

Sponsor: Organon and Co

Sex: All·Age: 3 Months - 23 Months

Code: NCT07265479·Phase 3·Recruiting

Apply to this trial

Diagnosing Epilepsy To EffeCT Change

for Epilepsy

18 locations incl. Phoenix

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110337·Recruiting

Apply to this trial

A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease

for Degenerative Disc Disease

14 locations incl. Birmingham

Sponsor: DiscGenics, Inc.

Sex: All·Age: 18 - 75

Code: NCT07254806·Phase 3·Recruiting

Apply to this trial

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

for Breast Neoplasms

117 locations incl. Anchorage

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07174336·Phase 3·Recruiting

Apply to this trial

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of MNKD-201 in Patients With Idiopathic Pulmonary Fibrosis

for Idiopathic Pulmonary Fibrosis (IPF)

9 locations incl. Fresno

Sponsor: Mannkind Corporation

Sex: All·Age: 40 - 85

Code: NCT07344558·Phase 1·Recruiting

Apply to this trial