Suzetrigine Frame Trial Comparing Suzetrigine and Acetaminophen

Conditions

• Analgesic Efficacy

Eligibility Criteria

Sex

ALL

Age

21 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Suzetrigine — DRUG
  100mg - Medication is self-administered at home on an empty stomach approximately 1-6 hours prior to the procedure.
• acetaminophen — DRUG
  1000mg - Medication is self-administered at home on an empty stomach approximately 1-6 hours prior to the procedure.

Study Details

Local anesthetic infiltration is a primary source of acute pain during stereotactic procedures.

Key Dates

First listed

Apr 13, 2026

Start date

Jun 22, 2026

Status verified

Apr 2026

Primary completion

Jul 31, 2027

Completion

Jul 31, 2027

Study Design

Enrollment

80 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Arms

• Active Comparator: Acetaminophen
  acetaminophen (1000 mg) - is self-administered at home on an empty stomach approximately 1-6 hours prior to the procedure.
• Experimental: Suzetrigine
  Suzetrigine (100mg) - is self-administered at home on an empty stomach approximately 1-6 hours prior to the procedure.

Primary Outcome Measure

Visual Analog Scale (VAS-Anxiety) score [ Time Frame: Baseline ]

Central Contacts

• Wendy Jenkins, BSN RN, CCRC
  336.716.3842
  [email protected]

Locations (1)

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