Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,479 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 4, 2026.

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3,012 clinical trials

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A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis

for Arthritis, Psoriatic

Sites in Philadelphia +15 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07321873·Phase 2·Recruiting·Listed Jan 2026

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Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis

for Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis

Drug: Vamifeport

Sites in York +18 more locations

Sponsor: CSL Behring

Sex: All·Age: 18+

Code: NCT07332091·Phase 2·Recruiting·Listed Jan 2026

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A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

for Huntington Disease

Sites in Philadelphia, Pittsburgh +32 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 21 - 70

Code: NCT07326709·Phase 3·Recruiting·Listed Jan 2026

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A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast Cancer

for Advanced Breast Cancer

Sites in Bethlehem, Sayre +18 more locations

Sponsor: TerSera Therapeutics LLC

Sex: Female·Age: 18 - 55

Code: NCT07310420·Phase 1·Recruiting·Listed Dec 2025

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AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

for Obesity

Drug: NNC0487-0111

Sites in Philadelphia +21 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07339423·Phase 3·Recruiting·Listed Jan 2026

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Pivotal Study of the SUpira System in Patients Undergoing High-Risk Percutaneous COronaRy InTervention (HRPCI)

for Coronary Artery Disease

Sites in Philadelphia, York +17 more locations

Sponsor: Supira Medical

Sex: All·Age: 18 - 90

Code: NCT07296744·Recruiting·Listed Dec 2025

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CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors

for Locally Advanced / Metastatic Solid Tumors

Sites in Pittsburgh +14 more locations

Sponsor: Crescent Biopharma, Inc.

Sex: All·Age: 18+

Code: NCT07335497·Phase 1, Phase 2·Recruiting·Listed Jan 2026

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A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

for NSCLC Adenocarcinoma

Sites in Philadelphia +16 more locations

Sponsor: IDEAYA Biosciences

Sex: All·Age: 18+

Code: NCT07277413·Phase 1·Recruiting·Listed Dec 2025

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A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)

for Ovarian Neoplasms

Sites in Philadelphia +25 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: Female·Age: 18+

Code: NCT07318558·Phase 3·Recruiting·Listed Jan 2026

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Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

for Amyotrophic Lateral Sclerosis

Sites in Philadelphia +17 more locations

Sponsor: Prilenia

Sex: All·Age: 18 - 80

Code: NCT07322003·Phase 3·Recruiting·Listed Jan 2026

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Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)

for Atrial Fibrillation (AF)

Sites in Philadelphia, Pittsburgh +20 more locations

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18+

Code: NCT07298473·Recruiting·Listed Dec 2025

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Phase 2A/B Efficacy and Safety of Dabogratinib in Participants With Low Grade Upper Tract Urothelial Carcinoma

for Low Grade Upper Tract Urothelial Carcinoma

Sites in Radnor +16 more locations

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT07265947·Phase 2·Recruiting·Listed Dec 2025

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A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy

for Spinal Muscular Atrophy (SMA)

Sites in Philadelphia +14 more locations

Sponsor: argenx

Sex: All·Age: 5 - 17

Code: NCT07287982·Phase 2·Recruiting·Listed Dec 2025

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A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201)

for Chronic Lymphocytic Leukemia (CLL)

Sites in Pittsburgh +24 more locations

Sponsor: Nurix Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07221500·Phase 2·Recruiting·Listed Oct 2025

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Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain

for Osteoarthritis Knee Pain

Sites in Altoona, Sewickley +20 more locations

Sponsor: Saol Therapeutics Inc

Sex: All·Age: 40+

Code: NCT07226258·Phase 3·Recruiting·Listed Nov 2025

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AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction

for Corneal Edema

Sites in Plymouth Meeting, Cynwyd +10 more locations

Sponsor: Aurion Biotech

Sex: All·Age: 18+

Code: NCT07368959·Phase 3·Recruiting·Listed Jan 2026

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A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)

for Cervical Cancer

Sites in Philadelphia, Willow Grove +23 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: Female·Age: 18+

Code: NCT07216703·Phase 3·Recruiting·Listed Oct 2025

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A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

for Asthma

Drug: Brenipatide

Sites in Pittsburgh +16 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07219173·Phase 2·Recruiting·Listed Oct 2025

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A Study of Praliciguat in Participants With Focal Segmental Glomerulosclerosis (FSGS)

for Focal Segmental Glomerulosclerosis

Sites in Butler, Bridgeville +22 more locations

Sponsor: Akebia Therapeutics

Sex: All·Age: 18+

Code: NCT07268638·Phase 2·Recruiting·Listed Dec 2025

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A Study to Investigate the Clinical Effect and the Safety of PRX-115 Infused Intravenously at Different Dosing Regimens, With and Without Methotrexate, Versus Placebo in Adults Gout Patients (RELEASE)

for Gout

Sites in Duncansville +17 more locations

Sponsor: Protalix

Sex: All·Age: 18+

Code: NCT07280156·Phase 2·Recruiting·Listed Dec 2025

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A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

for Major Depressive Disorder (MDD)

Sites in Media +22 more locations

Sponsor: Draig Therapeutics Ltd

Sex: All·Age: 18 - 75

Code: NCT07300969·Phase 2·Recruiting·Listed Dec 2025

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A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

for Human Immunodeficiency Virus Type 1 (HIV-1) Infection

Sites in Philadelphia +22 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07266831·Phase 2, Phase 3·Recruiting·Listed Dec 2025

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Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations

for Non-Small-Cell Lung Cancer

Sites in Philadelphia +19 more locations

Sponsor: ArriVent BioPharma, Inc.

Sex: All·Age: 18+

Code: NCT07185997·Phase 3·Recruiting·Listed Sep 2025

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A Gaucher Disease Gene Therapy Trial With FLT201

for Gaucher Disease Type 1

Sites in Philadelphia, Pittsburgh +14 more locations

Sponsor: Spur Therapeutics

Sex: All·Age: 18+

Code: NCT07223944·Phase 3·Recruiting·Listed Nov 2025

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A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

for Ovarian Neoplasms

Sites in Philadelphia +18 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07213791·Phase 1·Recruiting·Listed Oct 2025

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Study of MRM-3379 in Male Participants With Fragile X Syndrome (BLOOM)

for Fragile X Syndrome

Sites in Media +14 more locations

Sponsor: Mirum Pharmaceuticals, Inc.

Sex: Male·Age: 13 - 45

Code: NCT07209462·Phase 2·Recruiting·Listed Oct 2025

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Phase 2b Study of RPT904 as Monotherapy in Participants With IgE-Mediated Food Allergy

for Ig-E Mediated Food Allergy

Drug: RPT904

Sites in Philadelphia, Pittsburgh +20 more locations

Sponsor: RAPT Therapeutics, Inc.

Sex: All·Age: 12 - 55

Code: NCT07220811·Phase 2·Recruiting·Listed Oct 2025

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A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea

for Functional Hypothalamic Amenorrhea (FHA)

Sites in Hershey, Erie +8 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18 - 40

Code: NCT07235917·Phase 2·Recruiting·Listed Nov 2025

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Beeline: A Phase 3 Study in GRIN-related Neurodevelopmental Disorder

for GRIN-related Neurodevelopmental Disorder

Sites in Philadelphia +16 more locations

Sponsor: GRIN Therapeutics, Inc.

Sex: All·Age: 1 Month - 18

Code: NCT07224581·Phase 3·Recruiting·Listed Nov 2025

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Sarilumab Efficacy and Safety in Adults With Early Polymyalgia Rheumatica

for Polymyalgia Rheumatica

Sites in Duncansville, Wyomissing +11 more locations

Sponsor: Sanofi

Sex: All·Age: 50+

Code: NCT07286214·Phase 4·Recruiting·Listed Dec 2025

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A Study to Learn About the Effects of Felzartamab Infusions in Adults With Kidney Transplants Who Have Late Isolated Microvascular Inflammation

for Microvascular Inflammation

Sites in Philadelphia +21 more locations

Sponsor: Biogen

Sex: All·Age: 18 - 74

Code: NCT07219043·Phase 2·Recruiting·Listed Oct 2025

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A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

for Non-small Cell Lung Cancer

Drug: Calderasib

Sites in Lancaster +10 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07190248·Phase 3·Recruiting·Listed Sep 2025

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Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants Undergoing Open Abdominal Ventral Hernia Repair

for Ventral Hernia

Sites in Hershey +10 more locations

Sponsor: AbbVie

Sex: All·Age: 18 - 80

Code: NCT07226791·Phase 2·Recruiting·Listed Nov 2025

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A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas

for Bladder Cancer

Sites in Philadelphia +14 more locations

Sponsor: EvolveImmune United, Inc

Sex: All·Age: 18+

Code: NCT07217171·Phase 1·Recruiting·Listed Oct 2025

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Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

for Glioblastoma

Sites in Hershey +10 more locations

Sponsor: Alpheus Medical, Inc.

Sex: All·Age: 18 - 80

Code: NCT07225621·Phase 2·Recruiting·Listed Nov 2025

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A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

for Breast Cancer

Drug: Giredestrant

Sites in Philadelphia, Pittsburgh +24 more locations

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT07100106·Phase 1, Phase 2·Recruiting·Listed Aug 2025

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A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis

for Clinical High Risk for Psychosis (CHR)

Sites in Philadelphia, Pittsburgh +13 more locations

Sponsor: Monument Therapeutics Limited

Sex: All·Age: 17 - 30

Code: NCT07226895·Phase 1, Phase 2·Recruiting·Listed Nov 2025

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A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight

for Urinary Incontinence,Stress

Drug: Orforglipron

Sites in Philadelphia, Erie +18 more locations

Sponsor: Eli Lilly and Company

Sex: Female·Age: 18+

Code: NCT07202884·Phase 3·Recruiting·Listed Oct 2025

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A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

for Geographic Atrophy

Sites in Bethlehem +14 more locations

Sponsor: Sanofi

Sex: All·Age: 60+

Code: NCT07215234·Phase 1, Phase 2·Recruiting·Listed Oct 2025

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A Study to Evaluate the Effect of KarXT on Urological Safety

for Schizophrenia

Drug: KarXT

Sites in Philadelphia +12 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18 - 65

Code: NCT07221877·Phase 4·Recruiting·Listed Oct 2025

Apply to this trial