Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,479 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 4, 2026.

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3,012 clinical trials

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A Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in Pediatric Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)

for Transfusion-dependent Alpha-Thalassemia

Drug: Mitapivat

Sites in Philadelphia +2 more locations

Sponsor: Agios Pharmaceuticals, Inc.

Sex: All·Age: 1 - 17

Code: NCT07506863·Phase 3·Recruiting·Listed Apr 2026

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A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 2

for Narcolepsy Type 2

Drug: ALKS 2680

Sites in Wyomissing +21 more locations

Sponsor: Alkermes, Inc.

Sex: All·Age: 18 - 70

Code: NCT07502443·Phase 3·Recruiting·Listed Mar 2026

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A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis

for Systemic Sclerosis

Drug: Nerandomilast

Sites in Philadelphia +29 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07497087·Phase 3·Recruiting·Listed Mar 2026

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Pharmacokinetics, Pharmacodynamics, Safety and Tolerability Evaluation of CTAP101 Extended-release Capsules in Pediatric Participants

for CKD Stage 3

Sites in Philadelphia +4 more locations

Sponsor: OPKO Health, Inc.

Sex: All·Age: 1 Month - 17

Code: NCT07494045·Phase 2·Recruiting·Listed Mar 2026

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HeartBeam ECG Registry

for Atrial Fibrillation

1 location in Pittsburgh

Sponsor: HeartBeam, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07501299·Recruiting·Listed Mar 2026

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A Study to Investigate Abdominal Symptoms With Camlipixant Compared With Placebo in Adults With Irritable Bowel Syndrome - Diarrhea (IBS-D) and Irritable Bowel Syndrome - Mixed (IBS-M)

for Irritable Bowel Syndrome

Sites in Pittsburgh, Harrisburg +108 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18 - 80

Code: NCT07519395·Phase 2·Recruiting·Listed Apr 2026

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A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose Chemotherapy Plus Maintenance Over a Longer Amount of Time in Patients With Newly Diagnosed Intermediate-Risk Rhabdomyosarcoma (IR RMS)

for Rhabdomyosarcoma

Sites in Philadelphia, Pittsburgh +83 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT07466316·Phase 3·Recruiting·Listed Mar 2026

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A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia

for Schizophrenia

Sites in Philadelphia +41 more locations

Sponsor: MapLight Therapeutics

Sex: All·Age: 18 - 65

Code: NCT07459647·Phase 2·Recruiting·Listed Mar 2026

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Testing the Investigational Medication Combination of Teclistamab and Pomalidomide Compared to the Usual Treatment (Carfilzomib, Pomalidomide, and Dexamethasone) for Patients With Multiple Myeloma Who Have Relapsed Shortly After Treatment

for Recurrent Multiple Myeloma

Drug: Teclistamab

1 location in Philadelphia

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07463807·Phase 1, Phase 2·Recruiting·Listed Mar 2026

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A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1

for Narcolepsy Type 1

Drug: ALKS 2680

Sites in Wyomissing +21 more locations

Sponsor: Alkermes, Inc.

Sex: All·Age: 18 - 70

Code: NCT07455383·Phase 3·Recruiting·Listed Mar 2026

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A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma

for Asthma

Drug: Depemokimab

Sites in DuBois, Wyomissing +14 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 12+

Code: NCT07456033·Phase 3·Recruiting·Listed Mar 2026

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The Improving Sleep in African American Couples Study (ISAAC)

for Obstructive Sleep Apnea (OSA)

Sites in Pittsburgh +1 more location

Sponsor: MetroHealth Medical Center

Sex: All·Age: 30+

Code: NCT07447284·Recruiting·Listed Mar 2026

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Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

Sites in Chadds Ford +62 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07441681·Phase 3·Recruiting·Listed Mar 2026

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A Prospective Study of Pediatric Participants up to 16 Years of Age With Methylmalonic Acidemia (MMA) Due to Mutations in the MMUT Gene

for Methylmalonic Acidemia (MMA)

Sites in Philadelphia & Pittsburgh

Sponsor: Genespire Srl

Sex: All·Age: Up to 16

Code: NCT07432880·Recruiting·Listed Feb 2026

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First Time in Human (FTIH) Study to Investigate the Safety and Preliminary Activity of GSK5533524 Alone or in Combination in Adult Participants With Advanced Solid Tumors

for Neoplasms

Sites in Philadelphia +1 more location

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT07438782·Phase 1·Recruiting·Listed Feb 2026

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A Study of BMS-986528 in Participants With Refractory Rheumatoid Arthritis

for Arthritis, Rheumatoid

Drug: BMS-986528

Sites in Philadelphia +9 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18 - 65

Code: NCT07412704·Phase 1, Phase 2·Recruiting·Listed Feb 2026

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Ceribell Delirium Monitor Outcomes Pilot Study

for Delirium in the Intensive Care Unit

Sites in Pittsburgh +1 more location

Sponsor: Ceribell Inc.

Sex: All·Age: 18+

Code: NCT07449416·Recruiting·Listed Mar 2026

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A Study of VV-14305 for the Treatment of Thyroid Eye Disease

for Thyroid Eye Disease (TED)

Sites in Erie +2 more locations

Sponsor: Kriya Therapeutics, Inc.

Sex: All·Age: 18 - 80

Code: NCT07404111·Phase 1, Phase 2·Recruiting·Listed Feb 2026

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

Sites in Philadelphia, Pittsburgh +70 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting·Listed Feb 2026

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Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

for Fibromyalgia

Sites in Duncansville +50 more locations

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07398417·Phase 3·Recruiting·Listed Feb 2026

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An Evaluation of the Impact of Pharmacist Comprehensive Medication Management With Pharmacogenomic Results to Improve Depression Outcomes in Community Pharmacies.

for Pharmacogenetics

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT07373470·Recruiting·Listed Jan 2026

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A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung Cancer

for Small Cell Lung Cancer

Sites in Bethlehem +31 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07365241·Phase 3·Recruiting·Listed Jan 2026

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A Study to Find Out How Nerandomilast is Tolerated, Handled by the Body, and if it Helps Children and Adolescents With Interstitial Lung Disease (FIBRONEER-chILD)

for Fibrosing Interstitial Lung Disease

Drug: Nerandomilast

Sites in Philadelphia +6 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 2 - 17

Code: NCT07366034·Phase 3·Recruiting·Listed Jan 2026

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An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.

for Stomatitis

Sites in Wynnewood +29 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07357597·Phase 4·Recruiting·Listed Jan 2026

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52-week Open Label Safety-Tolerability Study

for Schizophrenia

Sites in Philadelphia +22 more locations

Sponsor: LB Pharmaceuticals Inc.

Sex: All·Age: 18 - 65

Code: NCT07369154·Phase 3·Recruiting·Listed Jan 2026

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A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents

for Suicide

Sites in Pittsburgh +2 more locations

Sponsor: Ksana Health

Sex: All·Age: 13 - 24

Code: NCT07348666·Recruiting·Listed Jan 2026

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First-Time-in-Human Study of GSK5471713 in Adults With mCRPC

for Neoplasms, Prostate

Sites in Philadelphia +3 more locations

Sponsor: GlaxoSmithKline

Sex: Male·Age: 18+

Code: NCT07332455·Phase 1, Phase 2·Recruiting·Listed Jan 2026

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NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease

for Graves Disease

Sites in Philadelphia +10 more locations

Sponsor: Merida Biosciences

Sex: All·Age: 18 - 65

Code: NCT07305818·Phase 1·Recruiting·Listed Dec 2025

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Donidalorsen Treatment in Children With Hereditary Angioedema

for Hereditary Angioedema (HAE)

Sites in Hershey +7 more locations

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 2 - 11

Code: NCT07298447·Phase 3·Recruiting·Listed Dec 2025

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A Study of KT-621 Administered Orally to Adult Participants With Moderate to Severe Eosinophilic Asthma

for Eosinophilic Asthma

Sites in Philadelphia, Pittsburgh +32 more locations

Sponsor: Kymera Therapeutics, Inc.

Sex: All·Age: 18 - 75

Code: NCT07323654·Phase 2·Recruiting·Listed Jan 2026

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A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)

for Amyotrophic Lateral Sclerosis

Sites in Philadelphia +6 more locations

Sponsor: Insmed Gene Therapy LLC

Sex: All·Age: 18 - 79

Code: NCT07290062·Phase 1·Recruiting·Listed Dec 2025

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Trial to Evaluate the Efficacy and Safety of LYT-100 (Deupirfenidone) Compared to Pirfenidone in Adults With Idiopathic Pulmonary Fibrosis (IPF)

for Idiopathic Pulmonary Fibrosis (IPF)

Sites in DuBois +9 more locations

Sponsor: PureTech

Sex: All·Age: 40+

Code: NCT07284602·Phase 3·Recruiting·Listed Dec 2025

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LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

for Pulmonary Hypertension Associated With HFpEF

Sites in Pittsburgh, Allentown +43 more locations

Sponsor: Tenax Therapeutics, Inc.

Sex: All·Age: 18 - 85

Code: NCT07288398·Phase 3·Recruiting·Listed Dec 2025

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Study of ENV-294 in Adults With Moderate-to-Severe Atopic Dermatitis

for Atopic Dermatitis (AD)

Sites in Camp Hill +31 more locations

Sponsor: Enveda Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07298395·Phase 2·Recruiting·Listed Dec 2025

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Neurobehavioral Changes Following Spaceflight Stressors

for Stressor, Individual

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 21 - 60·Accepts healthy volunteers

Code: NCT07293494·Recruiting·Listed Dec 2025

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Weight Bias Reducation Intervention With Nursing Students Using Simulation: The BRAVE Study

for Weight Bias

1 location in Villanova

Sponsor: Villanova University

Sex: All·Age: 18 - 35

Code: NCT07334470·Recruiting·Listed Jan 2026

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Health Advocate for Children After Liver Transplant

for Pediatric Liver Transplanted Recipients

Sites in Pittsburgh +1 more location

Sponsor: University of California, San Francisco

Sex: All·Age: 0 - 18

Code: NCT07279350·Recruiting·Listed Dec 2025

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Longitudinal Natural History Study of Retinal Function in Eyes of Patients With Diabetes

for Diabetic Retinal Disease

Sites in Monroeville +3 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18+

Code: NCT07270133·Recruiting·Listed Dec 2025

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Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

for Non-small Cell Lung Cancer (NSCLC)

Sites in Hershey, Lancaster +46 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07291037·Phase 3·Recruiting·Listed Dec 2025

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PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis

for Coronary Artery Disease Risk Factors Multiple

Sites in Philadelphia, Pittsburgh +21 more locations

Sponsor: Duke University

Sex: All·Age: 30 - 60

Code: NCT07232069·Phase 3·Recruiting·Listed Nov 2025

Apply to this trial