A Study of BMS-986528 in Participants With Refractory Rheumatoid Arthritis

Part of paid clinical trials in La Jolla, California.

Sponsor
Bristol-Myers Squibb
Study ID
NCT07412704
Phase
PHASE1/PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • BMS-986528 — DRUG
    Specified dose on specified days

Study Details

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and the preliminary evidence of disease-modifying effect of BMS-986528 in participants with refractory, difficult-to-treat rheumatoid arthritis (RA).

Key Dates

First listed
Feb 17, 2026
Start date
Sep 15, 2026
Status verified
Sep 2026
Primary completion
Oct 30, 2029
Completion
Sep 2, 2030

Study Design

Enrollment
84 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Cohort A1
  • Experimental: Cohort A2
  • Experimental: Cohort A3
  • Experimental: Cohort A4
  • Experimental: Cohort A5
  • Experimental: Cohort A6
  • Experimental: Cohort A7
  • Experimental: Cohort A8
  • Experimental: Cohort B1
  • Experimental: Cohort B2

Primary Outcome Measure

Number of participants with treatment-emergent adverse events (TEAEs) [ Time Frame: Up to Week 54 ]

Central Contacts

  • BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
    855-907-3286
    [email protected]
  • First line of the email MUST contain NCT # and Site #.

Locations (11)

FacilityCityStateZIPSite coordinators
Local Institution - 0068La JollaCalifornia92037
Site 0068
Local Institution - 0070Loma LindaCalifornia92354
Site 0070
Local Institution - 0069Palo AltoCalifornia94304-2210
Site 0069
Local Institution - 0050AuroraColorado80045
Site 0050
Colorado Blood Cancer InstituteDenverColorado80218
Richard Nash, Site 0067
303-981-2305
Local Institution - 0055South MiamiFlorida33143
Site 0055
Local Institution - 0079New YorkNew York10029
Site 0079
Local Institution - 0081New YorkNew York10016
Site 0081
Local Institution - 0066PortlandOregon97239
Site 0066
Local Institution - 0071PhiladelphiaPennsylvania19107
Site 0071
Local Institution - 0051DeSotoTexas75115-

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By research site
Local Institution - 0068· La Jolla, CALocal Institution - 0070· Loma Linda, CALocal Institution - 0069· Palo Alto, CALocal Institution - 0050· Aurora, COColorado Blood Cancer Institute· Denver, COLocal Institution - 0055· South Miami, FL

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