Clinical Trials at Mayo Clinic

As of August 2026, 387 paid clinical trials are recruiting at Mayo Clinic, located at 5360 KINGSBURY PL NW, ROCHESTER, MN 55901-2192, phone (507) 284-2511 in Rochester, Minnesota. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 10, 2026.

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391 clinical trials at Mayo Clinic

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MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

for Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

Sites in Rochester +36 more locations

Sponsor: Intellia Therapeutics

Sex: All·Age: 18 - 90

Code: NCT06128629·Phase 3·Recruiting·Listed Nov 2023

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Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury

for Acute Kidney Injury

Sites in Rochester +33 more locations

Sponsor: SeaStar Medical

Sex: All·Age: 18+

Code: NCT05758077·Recruiting·Listed Mar 2023

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CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)

for Relapsed Hematologic Malignancy

Drug: Emavusertib

Sites in Rochester +17 more locations

Sponsor: Curis, Inc.

Sex: All·Age: 18+

Code: NCT03328078·Phase 1, Phase 2·Recruiting·Listed Nov 2017

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Zenith® Fenestrated+ Clinical Study

for Aortic Aneurysm, Abdominal

Sites in Rochester +29 more locations

Sponsor: Cook Research Incorporated

Sex: All·Age: 18+

Code: NCT04875429·Recruiting·Listed May 2021

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Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis

Sites in Rochester +37 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18 - 75

Code: NCT06029972·Phase 2·Recruiting·Listed Sep 2023

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Endovascular AAA Intervention Using the GORE® EXCLUDER® Conformable AAA Endoprosthesis or Iliac Branch Endoprosthesis

for AAA - Abdominal Aortic Aneurysm

Sites in Rochester, Minneapolis +54 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06218875·Recruiting·Listed Jan 2024

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A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)

for Extensive Stage-small Cell Lung Cancer

Drug: Atezolizumab

Sites in Rochester, Minneapolis +23 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06362252·Phase 1, Phase 2·Recruiting·Listed Apr 2024

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Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

for Mesothelioma

Sites in Rochester +21 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05245500·Phase 1·Recruiting·Listed Feb 2022

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A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).

for Pediatric

Drug: Aficamten

Sites in Rochester +24 more locations

Sponsor: Cytokinetics

Sex: All·Age: 12 - 17

Code: NCT06412666·Phase 2, Phase 3·Recruiting·Listed May 2024

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SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistulas Study

for Chronic Kidney Diseases

Sites in Rochester +27 more locations

Sponsor: VenoStent

Sex: All·Age: 18+

Code: NCT06001827·Recruiting·Listed Aug 2023

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Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

for Prostate Cancer

Sites in Rochester, Minneapolis +28 more locations

Sponsor: Janux Therapeutics

Sex: Male·Age: 18 - 100

Code: NCT05519449·Phase 1·Recruiting·Listed Aug 2022

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CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.

for Epithelial Ovarian Cancer

Sites in Rochester, Minneapolis +24 more locations

Sponsor: TORL Biotherapeutics, LLC

Sex: Female·Age: 18+

Code: NCT06690775·Phase 2·Recruiting·Listed Nov 2024

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PARTNER 3 Trial - Aortic Valve-in-Valve

for Aortic Stenosis

Sites in Rochester +28 more locations

Sponsor: Edwards Lifesciences

Sex: All·Age: All ages

Code: NCT03003299·Recruiting·Listed Dec 2016

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Evaluation of the Fully Closed Loop Omnipod® System in Type 2 Diabetes

for Type 2 Diabetes Mellitus

Sites in Rochester, Minneapolis +24 more locations

Sponsor: Insulet Corporation

Sex: All·Age: 18 - 75

Code: NCT07521475·Recruiting·Listed Apr 2026

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A Study Comparing JNJ-79635322 and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Teclistamab

Sites in Rochester, Minneapolis +24 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07518186·Phase 3·Recruiting·Listed Apr 2026

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Study to Evaluate Resmetirom in Post-Liver Transplant Patients With MASH

for MASH - Metabolic Dysfunction-Associated Steatohepatitis

Sites in Rochester +15 more locations

Sponsor: Madrigal Pharmaceuticals, Inc.

Sex: All·Age: 18 - 75

Code: NCT07335601·Phase 2·Recruiting·Listed Jan 2026

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Horizon 360 Protocol for the Treatment of Paroxysmal Atrial Fibrillation With the Sphere-360™ Catheter and Affera™ Mapping and Ablation System (Horizon 360)

for Paroxysmal AF

Sites in Rochester, Minneapolis +22 more locations

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18 - 80

Code: NCT07308847·Recruiting·Listed Dec 2025

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Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain

for Osteoarthritis Knee Pain

Sites in Rochester +20 more locations

Sponsor: Saol Therapeutics Inc

Sex: All·Age: 40+

Code: NCT07226258·Phase 3·Recruiting·Listed Nov 2025

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Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

for Glioblastoma

Sites in Rochester +10 more locations

Sponsor: Alpheus Medical, Inc.

Sex: All·Age: 18 - 80

Code: NCT07225621·Phase 2·Recruiting·Listed Nov 2025

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Gene Therapy for HER-Positive Cancer (SENTRY-HER2)

for HER2 Expressing Solid Tumors

Sites in Rochester +10 more locations

Sponsor: Vironexis Biotherapeutics Inc.

Sex: All·Age: 18+

Code: NCT07192432·Phase 1, Phase 2·Recruiting·Listed Sep 2025

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Inobrodib, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma Refractory

Sites in Rochester +19 more locations

Sponsor: CellCentric Ltd.

Sex: All·Age: 18+

Code: NCT07096778·Phase 2·Recruiting·Listed Jul 2025

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A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

for Colorectal Neoplasms

Sites in Rochester +20 more locations

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT06131840·Phase 1·Recruiting·Listed Nov 2023

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ATLAS (AltaValve) Pivotal Trial

for Mitral Regurgitation

Sites in Rochester, Minneapolis +34 more locations

Sponsor: 4C Medical Technologies, Inc.

Sex: All·Age: 18+

Code: NCT06465745·Recruiting·Listed Jun 2024

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Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

Sites in Rochester +24 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06899126·Phase 3·Recruiting·Listed Mar 2025

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Sacral Neuromodulation for Male Overactive Bladder (MOAB)

for Overactive Bladder

Sites in Rochester +18 more locations

Sponsor: Axonics, Inc.

Sex: Male·Age: 18+

Code: NCT06511141·Recruiting·Listed Jul 2024

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BoxX-NoAF Clinical Trial

for Post Operative Atrial Fibrillation

Sites in Rochester +23 more locations

Sponsor: AtriCure, Inc.

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT06989775·Recruiting·Listed May 2025

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Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen

for Carcinoid Syndrome

Sites in Rochester +16 more locations

Sponsor: Crinetics Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT07087054·Phase 3·Recruiting·Listed Jul 2025

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Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease

for Primary Mitochondrial Disease

Sites in Rochester +19 more locations

Sponsor: Pharming Technologies B.V.

Sex: All·Age: 18+

Code: NCT05650229·Phase 2·Recruiting·Listed Dec 2022

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Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)

for Non-small Cell Lung Cancer (NSCLC)

Sites in Rochester +11 more locations

Sponsor: Nuvation Bio Inc.

Sex: All·Age: 18+

Code: NCT07154706·Phase 3·Recruiting·Listed Sep 2025

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A Study of Pirtobrutinib in Participants With Immune Thrombocytopenia

for Immune Thrombocytopenia (ITP)

Sites in Rochester +10 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06721013·Phase 1, Phase 2·Recruiting·Listed Dec 2024

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Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)

for Central Line Associated Blood Stream Infections (CLABSI)

Sites in Rochester +15 more locations

Sponsor: CorMedix Therapeutics

Sex: All·Age: 18+

Code: NCT06822426·Phase 3·Recruiting·Listed Feb 2025

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A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases

for Systemic Lupus Erythematosus

Drug: Inebilizumab

Sites in Rochester +11 more locations

Sponsor: Amgen

Sex: All·Age: 18 - 75

Code: NCT06570798·Phase 2·Recruiting·Listed Aug 2024

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Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant

for Pre-Bronchiolitis Obliterans Syndrome

Sites in Rochester +19 more locations

Sponsor: Renovion, Inc.

Sex: All·Age: 18 - 75

Code: NCT05654922·Phase 3·Recruiting·Listed Dec 2022

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A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors

for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Drug: Cemiplimab

Sites in Rochester +22 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT03972657·Phase 1, Phase 2·Recruiting·Listed Jun 2019

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A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

for Solid Tumor

Sites in Rochester +19 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04939610·Phase 1, Phase 2·Recruiting·Listed Jun 2021

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Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

for Treatment Resistant Depression

Sites in Rochester, Minneapolis +22 more locations

Sponsor: Abbott Medical Devices

Sex: All·Age: 22 - 70

Code: NCT06423430·Recruiting·Listed May 2024

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A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)

for PIK3CA-Related Overgrowth Spectrum (PROS)

Sites in Rochester +19 more locations

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 2+

Code: NCT06789913·Phase 2·Recruiting·Listed Jan 2025

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(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

for Indolent Systemic Mastocytosis

Sites in Rochester +13 more locations

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT04910685·Phase 2, Phase 3·Recruiting·Listed Jun 2021

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ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury

for Spinal Cord Injuries

Sites in Rochester +11 more locations

Sponsor: ONWARD Medical, Inc.

Sex: All·Age: 18 - 75

Code: NCT07147296·Recruiting·Listed Aug 2025

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VTP-1000 in Adults With Celiac Disease

for Celiac Disease

Sites in Rochester +15 more locations

Sponsor: Barinthus Biotherapeutics

Sex: All·Age: 18 - 70

Code: NCT06310291·EARLY_Phase 1·Recruiting·Listed Mar 2024

Apply to this trial