Clinical Trials at Mayo Clinic
As of September 2026, 390 paid clinical trials are recruiting at Mayo Clinic, located at 5360 KINGSBURY PL NW, ROCHESTER, MN 55901-2192, phone (507) 284-2511 in Rochester, Minnesota. Active studies at this site cover conditions such as Malignant Solid Neoplasm, Breast Cancer and Heart Failure. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.
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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Rochester
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Development of a Noninvasive Metric to Measure Small Bowel Sensation - The Small Intestine Stress Test
Islet Function in Gestational Diabetes
A Trial to Assess the Efficacy and Safety of Engasertib in Participants With Moderate to Severe Hereditary Hemorrhagic Telangiectasia (HHT)
Managing Depressive Symptoms in ADPKD
Community-Informed Interventions for Equitable Congestive Heart Failure Management in Primary Care
396 clinical trials at Mayo Clinic
·Clear filters·Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
VE303 for Prevention of Recurrent Clostridioides Difficile Infection
Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial
Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™
FOG-001 in Locally Advanced or Metastatic Solid Tumors
A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis
SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer
Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)
A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer
LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve
A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis
Zenith® Fenestrated+ Clinical Study
Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab
Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
DALY II USA/ MB-CART2019.1 for DLBCL
AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
Common conditions studied in Rochester
- Malignant Solid Neoplasm (20 active studies)
- Breast Cancer (15 active studies)
- Heart Failure (15 active studies)
- Ovarian Cancer (15 active studies)
- Multiple Myeloma (14 active studies)
- Healthy (13 active studies)
Leading research sponsors in Rochester
- Mayo Clinic
- National Cancer Institute (NCI)
- AstraZeneca
- Eli Lilly and Company
- Children's Oncology Group
Frequently asked questions
How many paid clinical trials are currently recruiting in Rochester?
There are approximately 1,222 recruiting clinical trials in Rochester, Minnesota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Rochester pay participants?
Most recruiting trials in Rochester compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Rochester?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Rochester?
The most common conditions under active study in Rochester include Malignant Solid Neoplasm (20), Breast Cancer (15), Heart Failure (15), Ovarian Cancer (15), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Rochester?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Rochester on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Rochester?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Rochester?
Recruiting research sites in Rochester include Mayo Clinic, Mayo Clinic in Rochester, Mayo Clinic Rochester, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Rochester right now?
The largest active categories in Rochester are Cancer & tumors (384), Cardiovascular (90), Neurology & pain (67). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
What is the address of Mayo Clinic?
Mayo Clinic is located at 5360 KINGSBURY PL NW, ROCHESTER, MN 55901-2192. Use the Google Maps link in the intro above to get directions.
How do I contact Mayo Clinic?
You can reach Mayo Clinic by phone at (507) 284-2511. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.