Managing Depressive Symptoms in ADPKD
for Autosomal Dominant Polycystic Kidney Disease
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18 - 70
Code: NCT07745920·Recruiting·Listed Aug 4, 2026
Clinical Trials at Mayo Clinic
As of August 2026, 387 paid clinical trials are recruiting at Mayo Clinic, located at 5360 KINGSBURY PL NW, ROCHESTER, MN 55901-2192, phone (507) 284-2511 in Rochester, Minnesota. Active studies at this site cover conditions such as Malignant Solid Neoplasm, Heart Failure and Multiple Myeloma. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.
View the full facility profile →
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Rochester
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Community-Informed Interventions for Equitable Congestive Heart Failure Management in Primary Care
for Congestive Heart Failure
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07730827·Recruiting·Listed Jul 28, 2026
DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
for Liver Cancer
Sites in Rochester +2 more locations
Sponsor: Maastricht University Medical Center
Sex: All·Age: 18+
Code: NCT07717437·Recruiting·Listed Jul 21, 2026
AAVrh10-PCCA Gene Therapy for Propionic Acidemia
for Propionic Acidemia
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 6 Months - 2
Code: NCT07643844·Phase 1·Recruiting·Listed Jun 2026
391 clinical trials at Mayo Clinic
·Clear filters·Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study
for Ventricular Arrythmia
Sites in Rochester +26 more locations
Sponsor: AtaCor Medical, Inc.
Sex: All·Age: 18+
Code: NCT07324031·Recruiting·Listed Jan 2026
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
for Cardiovascular Disease
Drug: Olpasiran
Sites in Rochester, Maplewood +197 more locations
Sponsor: Amgen
Sex: All·Age: 50 - 105
Code: NCT07136012·Phase 3·Recruiting·Listed Aug 2025
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
for Transthyretin Amyloid Cardiomyopathy (ATTR CM)
Drug: Coramitug
Sites in Rochester +59 more locations
Sponsor: Novo Nordisk A/S
Sex: All·Age: 18+
Code: NCT07207811·Phase 3·Recruiting·Listed Oct 2025
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
for Pediatric Migraine
Sites in Rochester +80 more locations
Sponsor: Pfizer
Sex: All·Age: 6 - 17
Code: NCT04649242·Phase 3·Recruiting·Listed Dec 2020
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
for Breast Cancer
Sites in Rochester, Mankato +167 more locations
Sponsor: Stemline Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06492616·Phase 3·Recruiting·Listed Jul 2024
A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes
for Diabetes Mellitus, Type 1
Sites in Rochester +43 more locations
Sponsor: Novo Nordisk A/S
Sex: All·Age: 18+
Code: NCT07076199·Phase 3·Recruiting·Listed Jul 2025
A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)
for Small-cell Lung Cancer
Drug: Durvalumab
Sites in Rochester, Edina +48 more locations
Sponsor: Amgen
Sex: All·Age: 18 - 99
Code: NCT07005128·Phase 3·Recruiting·Listed Jun 2025
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
for Neoplasms
Sites in Rochester, Minneapolis +76 more locations
Sponsor: Celgene
Sex: All·Age: All ages
Code: NCT03435796·Phase 2, Phase 3·Recruiting·Listed Feb 2018
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
for Lumbar Spinal Stenosis
Sites in Rochester, Burnsville +2341 more locations
Sponsor: Stryker Instruments
Sex: All·Age: 18+
Code: NCT03072927·Recruiting·Listed Mar 2017
Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis
for Primary Biliary Cholangitis
Sites in Rochester +50 more locations
Sponsor: Gilead Sciences
Sex: All·Age: 18+
Code: NCT06051617·Phase 3·Recruiting·Listed Sep 2023
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
for Pancreatic Neuroendocrine Tumor (pNET)
Sites in Rochester +39 more locations
Sponsor: Exelixis
Sex: All·Age: 18+
Code: NCT06943755·Phase 2, Phase 3·Recruiting·Listed Apr 2025
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
for Cachexia
Drug: ponsegromab
Sites in Rochester +80 more locations
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT06989437·Phase 2, Phase 3·Recruiting·Listed May 2025
A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis
for Antineutrophil Cytoplasmic Antibody-associated Vasculitis
Drug: Avacopan
Sites in Rochester, Minneapolis +56 more locations
Sponsor: Amgen
Sex: All·Age: 18 - 100
Code: NCT06072482·Phase 4·Recruiting·Listed Oct 2023
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
for Hypertension
Sites in Rochester, Bloomington +68 more locations
Sponsor: Orchestra BioMed, Inc
Sex: All·Age: 18+
Code: NCT06059638·Recruiting·Listed Sep 2023
A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer
for Hormone Receptor Positive HER-2 Negative Breast Cancer
Sites in Rochester, Minneapolis +32 more locations
Sponsor: Puma Biotechnology, Inc.
Sex: All·Age: 18+
Code: NCT06369285·Phase 2·Recruiting·Listed Apr 2024
Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD
for Geographic Atrophy (GA)
Sites in Rochester +52 more locations
Sponsor: ONL Therapeutics
Sex: All·Age: 55+
Code: NCT06659445·Phase 2·Recruiting·Listed Oct 2024
FOG-001 in Locally Advanced or Metastatic Solid Tumors
for Cancer
Sites in Rochester, Minneapolis +28 more locations
Sponsor: Parabilis Medicines, Inc.
Sex: All·Age: 18+
Code: NCT05919264·Phase 1, Phase 2·Recruiting·Listed Jun 2023
A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer
for Advanced Breast Cancer
Sites in Rochester +36 more locations
Sponsor: Stemline Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06638307·Phase 1·Recruiting·Listed Oct 2024
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial
for Tricuspid Regurgitation
Sites in Rochester +45 more locations
Sponsor: Edwards Lifesciences
Sex: All·Age: 18+
Code: NCT04097145·Recruiting·Listed Sep 2019
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
for Progressive Pulmonary Fibrosis
Sites in Rochester, Minneapolis +72 more locations
Sponsor: United Therapeutics
Sex: All·Age: 18+
Code: NCT05943535·Phase 3·Recruiting·Listed Jul 2023
LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve
for Superficial Bladder Cancer
Sites in Rochester, Minneapolis +46 more locations
Sponsor: enGene, Inc.
Sex: All·Age: 18+
Code: NCT04752722·Phase 1, Phase 2·Recruiting·Listed Feb 2021
A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis
for Non-cystic Fibrosis Bronchiectasis
Sites in Rochester +27 more locations
Sponsor: Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA
Sex: All·Age: 18 - 80
Code: NCT06559150·Phase 2·Recruiting·Listed Aug 2024
A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis
for Primary Biliary Cholangitis (PBC)
Drug: Elafibranor
Sites in Rochester +30 more locations
Sponsor: Ipsen
Sex: All·Age: 18+
Code: NCT06016842·Phase 3·Recruiting·Listed Aug 2023
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
for Colorectal Cancer
Sites in Rochester +31 more locations
Sponsor: Revolution Medicines, Inc.
Sex: All·Age: 18+
Code: NCT06445062·Phase 1, Phase 2·Recruiting·Listed Jun 2024
Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
for Breast Neoplasms
Sites in Rochester +38 more locations
Sponsor: Natera, Inc.
Sex: All·Age: 18+
Code: NCT07214532·Recruiting·Listed Oct 2025
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)
for Acute Respiratory Distress Syndrome (ARDS)
Sites in Rochester +39 more locations
Sponsor: PPD Development, LP
Sex: All·Age: 18+
Code: NCT06703073·Phase 2·Recruiting·Listed Nov 2024
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab
for Acute Respiratory Distress Syndrome (ARDS)
Drug: Bevacizumab
Sites in Rochester +39 more locations
Sponsor: PPD Development, LP
Sex: All·Age: 18+
Code: NCT06701656·Phase 2·Recruiting·Listed Nov 2024
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart
for Acute Respiratory Distress Syndrome (ARDS)
Drug: Cohort B: paridiprubart
Sites in Rochester +39 more locations
Sponsor: PPD Development, LP
Sex: All·Age: 18+
Code: NCT06701669·Phase 2·Recruiting·Listed Nov 2024
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab
for Acute Respiratory Distress Syndrome (ARDS)
Sites in Rochester +39 more locations
Sponsor: PPD Development, LP
Sex: All·Age: 18+
Code: NCT06701682·Phase 2·Recruiting·Listed Nov 2024
VE303 for Prevention of Recurrent Clostridioides Difficile Infection
for Clostridium Difficile
Sites in Rochester, Minneapolis +54 more locations
Sponsor: Vedanta Biosciences, Inc.
Sex: All·Age: 12+
Code: NCT06237452·Phase 3·Recruiting·Listed Feb 2024
DALY II USA/ MB-CART2019.1 for DLBCL
for Refractory Diffuse Large B Cell Lymphoma (DLBCL)
Sites in Rochester +27 more locations
Sponsor: Miltenyi Biomedicine GmbH
Sex: All·Age: 18+
Code: NCT04792489·Phase 2·Recruiting·Listed Mar 2021
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
for Heart Failure
Sites in Rochester, Minneapolis +55 more locations
Sponsor: Abbott Medical Devices
Sex: All·Age: 18+
Code: NCT06526195·Recruiting·Listed Jul 2024
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
for Aortic Valve Insufficiency
Sites in Rochester +31 more locations
Sponsor: Edwards Lifesciences
Sex: All·Age: All ages
Code: NCT05172973·Recruiting·Listed Dec 2021
REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE
for Aortic Stenosis
Sites in Rochester, Minneapolis +69 more locations
Sponsor: Medtronic Cardiovascular
Sex: All·Age: 18 - 105
Code: NCT06777368·Recruiting·Listed Jan 2025
A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
for Non-small Cell Lung Cancer
Sites in Rochester +22 more locations
Sponsor: Genentech, Inc.
Sex: All·Age: 18+
Code: NCT04302025·Phase 2·Recruiting·Listed Mar 2020
Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer
for Non-muscle Invasive Bladder Cancer
Sites in Rochester, Bloomington +31 more locations
Sponsor: Protara Therapeutics
Sex: All·Age: 18+
Code: NCT05951179·Phase 2·Recruiting·Listed Jul 2023
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis
for Primary Biliary Cholangitis
Sites in Rochester +29 more locations
Sponsor: Mirum Pharmaceuticals, Inc.
Sex: All·Age: 18+
Code: NCT05050136·Phase 2·Recruiting·Listed Sep 2021
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients
for Non-Small Cell Lung Cancer
Drug: Ivonescimab
Sites in Rochester, Saint Paul +74 more locations
Sponsor: Summit Therapeutics
Sex: All·Age: 18+
Code: NCT05899608·Phase 3·Recruiting·Listed Jun 2023
Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II
for Refractory Angina
Sites in Rochester, Minneapolis +63 more locations
Sponsor: Shockwave Medical, Inc.
Sex: All·Age: 18+
Code: NCT05102019·Recruiting·Listed Nov 2021
AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
for Symptomatic Heart Failure With Preserved Ejection Fraction (HFpEF)
Sites in Rochester +23 more locations
Sponsor: Cytokinetics
Sex: All·Age: 40 - 85
Code: NCT06793371·Phase 2·Recruiting·Listed Jan 2025
Common conditions studied in Rochester
- Malignant Solid Neoplasm (19 active studies)
- Heart Failure (16 active studies)
- Multiple Myeloma (16 active studies)
- Ovarian Cancer (15 active studies)
- Breast Cancer (14 active studies)
- Healthy (14 active studies)
Leading research sponsors in Rochester
- Mayo Clinic
- National Cancer Institute (NCI)
- AstraZeneca
- Eli Lilly and Company
- Children's Oncology Group
Frequently asked questions
How many paid clinical trials are currently recruiting in Rochester?
There are approximately 1,200 recruiting clinical trials in Rochester, Minnesota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Rochester pay participants?
Most recruiting trials in Rochester compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Rochester?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Rochester?
The most common conditions under active study in Rochester include Malignant Solid Neoplasm (19), Heart Failure (16), Multiple Myeloma (16), Ovarian Cancer (15), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Rochester?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Rochester on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Rochester?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Rochester?
Recruiting research sites in Rochester include Mayo Clinic, Mayo Clinic in Rochester, Mayo Clinic Rochester, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Rochester right now?
The largest active categories in Rochester are Cancer & tumors (371), Cardiovascular (93), Neurology & pain (69). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
What is the address of Mayo Clinic?
Mayo Clinic is located at 5360 KINGSBURY PL NW, ROCHESTER, MN 55901-2192. Use the Google Maps link in the intro above to get directions.
How do I contact Mayo Clinic?
You can reach Mayo Clinic by phone at (507) 284-2511. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.
Browse more clinical trials
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