Paid Clinical Trials in South Carolina

South Carolina has 1,217 paid clinical trials enrolling now across cities including Charleston, Greenville and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

Filter results

State

City

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

1,101 clinical trials

Get a weekly email when new trials open in Charleston, SC.

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability Evaluation of CTAP101 Extended-release Capsules in Pediatric Participants

for CKD Stage 3

Sites in Greenville +4 more locations

Sponsor: OPKO Health, Inc.

Sex: All·Age: 1 Month - 17

Code: NCT07494045·Phase 2·Recruiting·Listed Mar 2026

Apply to this trial

A Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH)

for Pulmonary Arterial Hypertension

Sites in Anderson +5 more locations

Sponsor: Insmed Incorporated

Sex: All·Age: 18 - 75

Code: NCT07481981·Phase 3·Recruiting·Listed Mar 2026

Apply to this trial

Efficacy and Safety Study to Evaluate SD-101 in Epidermolysis Bullosa

for Epidermolysis Bullosa (EB)

Sites in Charleston +2 more locations

Sponsor: Paradigm Therapeutics

Sex: All·Age: 28 Days - 12

Code: NCT07482787·Phase 3·Recruiting·Listed Mar 2026

Apply to this trial

Dose Ranging Study of ORKA-002 in Patients With Moderate-to-Severe Plaque Psoriasis

for Plaque Psoriasis

Sites in Charleston +28 more locations

Sponsor: Oruka Therapeutics, Inc.

Sex: All·Age: 18 - 79

Code: NCT07474792·Phase 2·Recruiting·Listed Mar 2026

Apply to this trial

A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1

for Narcolepsy Type 1

Drug: ALKS 2680

Sites in Columbia +21 more locations

Sponsor: Alkermes, Inc.

Sex: All·Age: 18 - 70

Code: NCT07455383·Phase 3·Recruiting·Listed Mar 2026

Apply to this trial

A Study to Evaluate Claudin 18.2-Directed ADC LCB02A in Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Charleston +3 more locations

Sponsor: LigaChem Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT07460375·Phase 1, Phase 2·Recruiting·Listed Mar 2026

Apply to this trial

Progesterone Preeclampsia

for Preeclampsia

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07448597·Phase 4·Recruiting·Listed Mar 2026

Apply to this trial

A Study of Lurbinectedin in Combination With Durvalumab for the Treatment of Participants With ES-SCLC

for Extensive-stage Small-cell Lung Cancer

Drug: Lurbinectedin

Sites in Rock Hill +3 more locations

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07459634·Phase 2·Recruiting·Listed Mar 2026

Apply to this trial

Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

Sites in Charleston +79 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting·Listed Feb 2026

Apply to this trial

ColoSeal™ ICD System Anastomotic Protection Pivotal Study

for Rectal Cancer Surgery

Sites in Charleston +5 more locations

Sponsor: Averto Medical, Inc.

Sex: All·Age: 22 - 75

Code: NCT07429110·Recruiting·Listed Feb 2026

Apply to this trial

A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Administered as Intramuscular Injection to Healthy Children 15 Months to 6 Years of Age

for Measles

Sites in Spartanburg, Simpsonville +15 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 15 Months - 6·Accepts healthy volunteers

Code: NCT07406360·Phase 3·Recruiting·Listed Feb 2026

Apply to this trial

Aquarius Pilot Study to Evaluate the New Axonics Trial System

for Urinary Urge Incontinence (UUI)

1 location in West Columbia

Sponsor: Axonics, Inc.

Sex: All·Age: 18+

Code: NCT07335484·Recruiting·Listed Jan 2026

Apply to this trial

A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs

for Prostate Cancer

Sites in Myrtle Beach +7 more locations

Sponsor: AstraZeneca

Sex: Male·Age: 18+

Code: NCT07336446·Phase 1, Phase 2·Recruiting·Listed Jan 2026

Apply to this trial

Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

for Non-small Cell Lung Cancer (NSCLC)

Sites in Greenville +47 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07291037·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

Trial to Evaluate the Efficacy and Safety of LYT-100 (Deupirfenidone) Compared to Pirfenidone in Adults With Idiopathic Pulmonary Fibrosis (IPF)

for Idiopathic Pulmonary Fibrosis (IPF)

Sites in Rock Hill +9 more locations

Sponsor: PureTech

Sex: All·Age: 40+

Code: NCT07284602·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

A Study of KT-621 Administered Orally to Adult Participants With Moderate to Severe Eosinophilic Asthma

for Eosinophilic Asthma

Sites in North Charleston, Rock Hill +32 more locations

Sponsor: Kymera Therapeutics, Inc.

Sex: All·Age: 18 - 75

Code: NCT07323654·Phase 2·Recruiting·Listed Jan 2026

Apply to this trial

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

for Pulmonary Hypertension Associated With HFpEF

Sites in Charleston +44 more locations

Sponsor: Tenax Therapeutics, Inc.

Sex: All·Age: 18 - 85

Code: NCT07288398·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

ENV-294 for Moderate-to-Severe Asthma: A 12-Week Study in Adults

for Asthma

Sites in North Charleston +17 more locations

Sponsor: Enveda Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07301255·Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

A Study to Investigate Efficacy and Safety of KP-001 Compared With Placebo in Patients Aged ≥2 Years With Common VM, Common LM, or KTS/CLOVES Syndrome

for Venous Malformations

1 location in Charleston

Sponsor: Kaken Pharmaceutical

Sex: All·Age: 2+

Code: NCT07285005·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis

for Coronary Artery Disease Risk Factors Multiple

Sites in Charleston +22 more locations

Sponsor: Duke University

Sex: All·Age: 30 - 60

Code: NCT07232069·Phase 3·Recruiting·Listed Nov 2025

Apply to this trial

A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

for Gastrointestinal Neoplasms

Sites in Spartanburg +47 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT07218926·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis

for Rheumatoid Arthritis

Drug: AZD1163

Sites in Myrtle Beach +21 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07276581·Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

for Sepsis

Sites in Charleston +13 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 80

Code: NCT07215702·Phase 2·Recruiting·Listed Oct 2025

Apply to this trial

Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

for Metastatic Prostate Cancer

Sites in Myrtle Beach +8 more locations

Sponsor: AstraZeneca

Sex: Male·Age: 18 - 130

Code: NCT07181161·Phase 1, Phase 2·Recruiting·Listed Sep 2025

Apply to this trial

A Study to Assess the Effectiveness and Safety of GSK3862995B in Adults With Bronchiectasis

for Bronchiectasis

Sites in Spartanburg, Anderson +29 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18 - 85

Code: NCT07201051·Phase 2·Recruiting·Listed Oct 2025

Apply to this trial

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

for HNSCC

Sites in Charleston +17 more locations

Sponsor: Normunity AccelCo, Inc.

Sex: All·Age: 18+

Code: NCT07182149·Phase 1·Recruiting·Listed Sep 2025

Apply to this trial

A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)

for Inflammatory Arthritis

Sites in Charleston +3 more locations

Sponsor: Smith & Nephew, Inc.

Sex: All·Age: 18 - 80

Code: NCT07199738·Recruiting·Listed Sep 2025

Apply to this trial

A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

for Chronic Obstructive Pulmonary Disease (COPD)

Drug: AZD6793

Sites in Spartanburg, Lancaster +70 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40+

Code: NCT07082738·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation

for Pulmonary Disease, Chronic Obstructive

Drug: Depemokimab

Sites in Greenville, Rock Hill +40 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 40 - 75

Code: NCT07177339·Phase 3·Recruiting·Listed Sep 2025

Apply to this trial

HS235 Study in Obese Participants With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction (HFpEF)

for Pulmonary Hypertension

1 location in Greenville

Sponsor: 35Pharma Inc

Sex: All·Age: 18+

Code: NCT07123779·Phase 1, Phase 2·Recruiting·Listed Aug 2025

Apply to this trial

A Study to Evaluate the Efficacy, Safety, and PK of AZD0292 Administered IV in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization

for Bronchiectasis With Pseudomonas Aeruginosa Colonization

Sites in Charleston, Rock Hill +17 more locations

Sponsor: AstraZeneca

Sex: All·Age: 12+

Code: NCT07088926·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

for Hypertriglyceridemia

Sites in Little River +6 more locations

Sponsor: Marea Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07028749·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis

for Atopic Dermatitis

Sites in Charleston +22 more locations

Sponsor: Apogee Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07003425·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

for Endometrial Cancer

Drug: Rilvegostomig

Sites in Charleston +46 more locations

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT06989112·Phase 3·Recruiting·Listed May 2025

Apply to this trial

A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

for Cardiovascular Disease

Drug: AZD0780

Sites in Charleston, North Charleston +308 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07000357·Phase 3·Recruiting·Listed Jun 2025

Apply to this trial

An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD)

for REM Sleep Behavior Disorder

Sites in Charleston +17 more locations

Sponsor: Yale University

Sex: All·Age: 50 - 80

Code: NCT06996652·Phase 2·Recruiting·Listed May 2025

Apply to this trial

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

for Heart Failure and Impaired Kidney Function

Drug: Dapagliflozin

Sites in Charleston, Lancaster +108 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06307652·Phase 3·Recruiting·Listed Mar 2024

Apply to this trial

A Study to Compare the Efficacy, Safety and Tolerability of FF/UMEC/VI With FF/VI in 12-17-year-olds With Asthma

for Asthma

Sites in Charleston +19 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 12 - 17

Code: NCT05757102·Phase 3·Recruiting·Listed Mar 2023

Apply to this trial

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Rock Hill +67 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06883305·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Columbia, Spartanburg +60 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06878261·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial