Clinical Trials at Mercy Hospital Springfield

As of August 2026, 60 paid clinical trials are recruiting at Mercy Hospital Springfield, located at 1229 E SEMINOLE ST, SPRINGFIELD, MO 65804-2227, phone (417) 820-5089 in Springfield, Missouri. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

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60 clinical trials at Mercy Hospital Springfield

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Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Springfield, Lee's Summit +56 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500481·Phase 3·Recruiting·Listed Jul 2024

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Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer

for Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8

Sites in Springfield +40 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 18+

Code: NCT05646316·Phase 3·Recruiting·Listed Dec 2022

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Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors

for Malignant Solid Neoplasm

Sites in Springfield, Branson +586 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04871542·Recruiting·Listed May 2021

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De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

for Stage I Breast Cancer

Sites in Springfield, Joplin +705 more locations

Sponsor: NRG Oncology

Sex: All·Age: 50 - 70

Code: NCT04852887·Phase 3·Recruiting·Listed Apr 2021

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Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network, STOP-VTE Study

for Malignant Digestive System Neoplasm

Sites in Springfield, Branson +56 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07215624·Recruiting·Listed Oct 2025

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S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Springfield, Branson +584 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03723928·Recruiting·Listed Oct 2018

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

Sites in Springfield, Columbia +140 more locations

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting·Listed Apr 2019

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Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

for Colorectal Cancer Stage II

Sites in Springfield, Branson +373 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07018869·Phase 3·Recruiting·Listed Jun 2025

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Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

for Breast Carcinoma

Sites in Springfield, Joplin +462 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06418204·Recruiting·Listed May 2024

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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Springfield, Branson +913 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05929768·Phase 3·Recruiting·Listed Jul 2023

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Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

for Metastatic Malignant Neoplasm in the Liver

Sites in Springfield, Branson +378 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05040360·Phase 2·Recruiting·Listed Sep 2021

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Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

for Metastatic Lung Small Cell Carcinoma

Sites in Springfield, Joplin +146 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT04804644·Phase 3·Recruiting·Listed Mar 2021

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LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

for Advanced Colorectal Carcinoma

Sites in Springfield, Sullivan +194 more locations

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT06073431·Recruiting·Listed Oct 2023

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Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

for Colorectal Cancer

Sites in Springfield, Sullivan +140 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 60+

Code: NCT03998202·Recruiting·Listed Jun 2019

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S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

for Cardiotoxicity

Sites in Springfield, Jefferson City +142 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03418961·Phase 3·Recruiting·Listed Feb 2018

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A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

for Clinical Stage IV Cutaneous Melanoma AJCC v8

Drug: Ipilimumab

Sites in Springfield, Branson +301 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04511013·Phase 2·Recruiting·Listed Aug 2020

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Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for Metastatic Clear Cell Renal Cell Carcinoma

Sites in Springfield, Branson +338 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04510597·Phase 3·Recruiting·Listed Aug 2020

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Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

for Castration Levels of Testosterone

Sites in Springfield, Joplin +292 more locations

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT03678025·Phase 3·Recruiting·Listed Sep 2018

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Collection and Storage of Tissue and Blood Samples From Patients With Cancer

for Hematopoietic and Lymphatic System Neoplasm

Sites in Springfield, Joplin +20 more locations

Sponsor: National Cancer Institute LAO

Sex: All·Age: 2 Months+

Code: NCT02474160·Recruiting·Listed Jun 2015

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Testing the Addition of Duvelisib or CC-486 to the Usual Treatment for Peripheral T-Cell Lymphoma

for Angioimmunoblastic T-cell Lymphoma

Sites in Springfield, Chesterfield +84 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT04803201·Phase 2·Recruiting·Listed Mar 2021

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