As of August 2026, 126 paid clinical trials are recruiting in Springfield, Missouri. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Springfield offers studies at sites including Mercy Hospital Springfield for conditions such as Obesity, Overweight, Anatomic Stage IV Breast Cancer AJCC v8, Malignant Solid Neoplasm. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Researchers run research studies in Springfield, MO at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Mercy Hospital Springfield | Anatomic Stage IV Breast Cancer AJCC v8, Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Brain | 63 |
| CoxHealth South Hospital | Malignant Solid Neoplasm, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | 48 |
| Oncology Hematology Associates | Neoplasm Metastasis, Carcinoma, Non-Small-Cell Lung, Breast Cancer | 11 |
| Clinvest Research LLC | Chronic Pain, Osteoarthritis, Knee, Chronic Low-back Pain | 6 |
| Clinvest Headlands Llc | Obesity, Overweight, Menstrual Migraine | 6 |
| GSK Investigational Site | Non-alcoholic Fatty Liver Disease, Multiple Myeloma | 3 |
| Cox Medical Center South | Atrial Fibrillation, Bronchiolitis Acute, Intracerebral Hemorrhage | 3 |
| Mercy Clinic Cancer and Hematology - Chub O'Reilly Cancer Center | Colorectal Cancer, Non-Small Cell Lung Cancer | 2 |
| Bio-Kinetic Clinical Applications, LLC dba QPS-MO | Healthy | 2 |
| ACCOMPLISH-2 Research Site | Chronic Weight Management, Obesity, Overweight | 1 |
| Clinical Study Site | Metastatic Colorectal Cancer (CRC) | 1 |
| Clinvest Research | Obesity, Osteoarthritis, Knee, Overweight | 1 |
| Cox Health | AAA - Abdominal Aortic Aneurysm | 1 |
| Cox Health South Hospital | Breast Carcinoma, Colorectal Carcinoma, Lung Non-Small Cell Carcinoma | 1 |
| Cox Medical Center | Triple Negative Breast Cancer | 1 |
| Cox Medical Center North | Fallopian Tube Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms | 1 |
| Cox Medical Center North | Non-small Cell Lung Cancer | 1 |
| Cox South Hospital | Cutaneous Melanoma, Stage II | 1 |
| CoxHealth | Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation, Ventricular Arrhythmia | 1 |
| DelRicht Clinical Research - Springfield | Chronic Idiopathic Constipation (CIC) | 1 |
| DelRicht Research | Body Weight, Nutrition Disorders, Nutritional and Metabolic Diseases | 1 |
| Headlands Research | Diabetes Mellitus, Type 2 | 1 |
| Hulston Cancer Center | Non Small Cell Lung Cancer | 1 |
| Mercy CH Chub O'Reilly Cancer Center | Metastatic Pancreatic Adenocarcinoma, Metastatic Pancreatic Cancer, Pancreatic Cancer | 1 |
| Mercy Children's Hospital - Springfield | Normal and Diseased Tissue and Body Fluids Samples | 1 |
Recruiting trials in Springfield grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
There are approximately 126 recruiting clinical trials in Springfield, Missouri listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Springfield compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Springfield include Obesity (7), Overweight (7), Anatomic Stage IV Breast Cancer AJCC v8 (5), Malignant Solid Neoplasm (5), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Springfield on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Springfield include Mercy Hospital Springfield, CoxHealth South Hospital, Oncology Hematology Associates, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Springfield are Cancer & tumors (82), Diabetes & metabolic (11), Neurology & pain (7). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.