MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
for Lumbar Spinal Stenosis
Sites in Springfield, Lebanon +2386 more locations
Sponsor: Stryker Instruments
Sex: All·Age: 18+
Code: NCT03072927·Recruiting·Listed Mar 2017
Clinical Trials at Mercy Hospital Springfield
As of September 2026, 57 paid clinical trials are recruiting at Mercy Hospital Springfield, located at 1229 E SEMINOLE ST, SPRINGFIELD, MO 65804-2227, phone (417) 820-5089 in Springfield, Missouri. Active studies at this site cover conditions such as Obesity, Overweight and Malignant Solid Neoplasm. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.
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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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57 clinical trials at Mercy Hospital Springfield
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Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
for Pulmonary Hypertension
Sites in Springfield, Hannibal +35 more locations
Sponsor: Tempus AI
Sex: All·Age: 18+
Code: NCT06911632·Recruiting·Listed Apr 2025
Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
for Ampulla of Vater Carcinoma
Sites in Springfield, Branson +346 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT07283939·Recruiting·Listed Dec 2025
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
for Breast Cancer
Sites in Springfield, Branson +1087 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 18 - 60
Code: NCT05879926·Phase 3·Recruiting·Listed May 2023
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
for Head and Neck Squamous Cell Carcinoma
Sites in Springfield, Branson +461 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT02734537·Phase 2·Recruiting·Listed Apr 2016
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
for Stage III Colon Cancer
Sites in Springfield, Branson +923 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas
for Intracranial Meningioma
Sites in Springfield, Branson +446 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT02523014·Phase 2·Recruiting·Listed Aug 2015
mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma
for Advanced Esophageal Adenocarcinoma
Drug: Nivolumab
Sites in Springfield, Branson +626 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT05677490·Phase 3·Recruiting·Listed Jan 2023
Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer
for Advanced Endometrial Carcinoma
Drug: Bevacizumab
Sites in Springfield, Columbia +266 more locations
Sponsor: National Cancer Institute (NCI)
Sex: Female·Age: 18+
Code: NCT07198074·Phase 3·Recruiting·Listed Sep 2025
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
for Acute Lymphoblastic Leukemia
Sites in Springfield, Branson +612 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 40 - 75·Accepts healthy volunteers
Code: NCT05334069·Recruiting·Listed Apr 2022
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
for Advanced Malignant Solid Neoplasm
Sites in Springfield, Sullivan +427 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: All ages
Code: NCT05564377·Phase 2·Recruiting·Listed Oct 2022
Family Communications After Genetic Testing
for Colon Adenocarcinoma
Sites in Springfield, Branson +308 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT07143487·Recruiting·Listed Aug 2025
Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
for Adenocarcinoma of the Colon
Sites in Springfield, Branson +331 more locations
Sponsor: NRG Oncology
Sex: All·Age: 45 - 70
Code: NCT05080673·Recruiting·Listed Oct 2021
Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer
for Miscellaneous Neoplasm, Nos
Sites in Springfield, Branson +308 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT07091617·Recruiting·Listed Jul 2025
Ramucirumab and Paclitaxel or FOLFIRI in Advanced Small Bowel Cancers
for Metastatic Small Intestinal Adenocarcinoma
Sites in Springfield, Branson +397 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT04205968·Phase 2·Recruiting·Listed Dec 2019
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
for Acral Lentiginous Melanoma
Drug: Ipilimumab
Sites in Springfield, Branson +301 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT04511013·Phase 2·Recruiting·Listed Aug 2020
APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
for Pancreatic Acinar Cell Carcinoma
Drug: Olaparib
Sites in Springfield, Lee's Summit +256 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT04858334·Phase 2·Recruiting·Listed Apr 2021
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial
for Plasma Cell Myeloma
Sites in Springfield, Branson +303 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT04566328·Phase 3·Recruiting·Listed Sep 2020
Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial
for Metastatic Renal Cell Carcinoma
Sites in Springfield, Columbia +278 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT05327686·Phase 2·Recruiting·Listed Apr 2022
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study
for Muscle Invasive Bladder Urothelial Carcinoma
Sites in Springfield, Columbia +441 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT05987241·Phase 2, Phase 3·Recruiting·Listed Aug 2023
Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma
for Smoldering Plasma Cell Myeloma
Drug: Daratumumab
Sites in Springfield, Joplin +482 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT03937635·Phase 3·Recruiting·Listed May 2019
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
for Anatomic Stage II Breast Cancer AJCC v8
Sites in Springfield, Columbia +777 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT05812807·Phase 3·Recruiting·Listed Apr 2023
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
for Locally Advanced Cervical Adenocarcinoma
Sites in Springfield, Joplin +318 more locations
Sponsor: National Cancer Institute (NCI)
Sex: Female·Age: 18+
Code: NCT07061977·Phase 3·Recruiting·Listed Jul 2025
Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program
for Cigarette Smoking-Related Carcinoma
Sites in Springfield, Rolla +203 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT05008848·Phase 3·Recruiting·Listed Aug 2021
Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer
for Astrocytoma, IDH-Mutant, Grade 3
Drug: Vorasidenib
Sites in Springfield, Lee's Summit +115 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 12+
Code: NCT07215910·Phase 3·Recruiting·Listed Oct 2025
Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma
for Mantle Cell Lymphoma
Sites in Springfield, Lee's Summit +225 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 60+
Code: NCT05976763·Phase 3·Recruiting·Listed Aug 2023
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
for Fallopian Tube Endometrioid Adenocarcinoma
Drug: Bevacizumab
Sites in Springfield, Branson +653 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT06580314·Phase 3·Recruiting·Listed Aug 2024
Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change
for Advanced Lung Non-Small Cell Carcinoma
Drug: Osimertinib
Sites in Springfield, Branson +215 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT03191149·Phase 2·Recruiting·Listed Jun 2017
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer
for Locally Advanced Lung Non-Small Cell Carcinoma
Sites in Springfield, Joplin +444 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT05624996·Phase 3·Recruiting·Listed Nov 2022
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer
for Prostate Adenocarcinoma
Sites in Springfield, Rolla +397 more locations
Sponsor: NRG Oncology
Sex: Male·Age: 18+
Code: NCT05946213·Phase 3·Recruiting·Listed Jul 2023
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging
for Biochemically Recurrent Prostate Carcinoma
Drug: Apalutamide
Sites in Springfield, Joplin +276 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: Male·Age: 18+
Code: NCT04423211·Phase 3·Recruiting·Listed Jun 2020
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial
for Metastatic Colorectal Adenocarcinoma
Sites in Springfield, Columbia +163 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT05673148·Phase 2·Recruiting·Listed Jan 2023
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
for Hematopoietic and Lymphatic System Neoplasm
Sites in Springfield, Branson +189 more locations
Sponsor: Children's Oncology Group
Sex: Female·Age: Up to 39
Code: NCT06513962·Phase 3·Recruiting·Listed Jul 2024
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer
for Ovarian Carcinoma
Sites in Springfield, St Louis +479 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 35 - 50
Code: NCT04251052·Recruiting·Listed Jan 2020
E-Mindfulness Approaches for Living After Breast Cancer
for Breast Cancer
Sites in Springfield, St Louis +372 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18 - 50
Code: NCT06748222·Phase 3·Recruiting·Listed Dec 2024
Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer
for Refractory Differentiated Thyroid Gland Carcinoma
Sites in Springfield, Branson +284 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT06475989·Phase 3·Recruiting·Listed Jun 2024
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study
for Muscle Invasive Bladder Urothelial Carcinoma
Sites in Springfield, Joplin +206 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT07097142·Phase 3·Recruiting·Listed Jul 2025
Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment
for Plasma Cell Myeloma
Sites in Springfield, Branson +387 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: All ages
Code: NCT05561387·Phase 3·Recruiting·Listed Sep 2022
Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial
for Anatomic Stage IV Breast Cancer AJCC v8
Sites in Springfield, Lee's Summit +56 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT06500481·Phase 3·Recruiting·Listed Jul 2024
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer
for Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
Sites in Springfield +40 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 18+
Code: NCT05646316·Phase 3·Recruiting·Listed Dec 2022
Common conditions studied in Springfield
- Obesity (6 active studies)
- Overweight (6 active studies)
- Malignant Solid Neoplasm (5 active studies)
- Cancer (4 active studies)
- Neoplasm Metastasis (4 active studies)
- Anatomic Stage II Breast Cancer AJCC v8 (3 active studies)
Leading research sponsors in Springfield
- NRG Oncology
- Alliance for Clinical Trials in Oncology
- Eli Lilly and Company
- SWOG Cancer Research Network
- National Cancer Institute (NCI)
Frequently asked questions
How many paid clinical trials are currently recruiting in Springfield?
There are approximately 124 recruiting clinical trials in Springfield, Missouri listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Springfield pay participants?
Most recruiting trials in Springfield compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Springfield?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Springfield?
The most common conditions under active study in Springfield include Obesity (6), Overweight (6), Malignant Solid Neoplasm (5), Cancer (4), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Springfield?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Springfield on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Springfield?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Springfield?
Recruiting research sites in Springfield include Mercy Hospital Springfield, CoxHealth South Hospital, Oncology Hematology Associates, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Springfield right now?
The largest active categories in Springfield are Cancer & tumors (76), Diabetes & metabolic (11), Neurology & pain (7). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
What is the address of Mercy Hospital Springfield?
Mercy Hospital Springfield is located at 1229 E SEMINOLE ST, SPRINGFIELD, MO 65804-2227. Use the Google Maps link in the intro above to get directions.
How do I contact Mercy Hospital Springfield?
You can reach Mercy Hospital Springfield by phone at (417) 820-5089. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.
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