Vaccine Therapy and Chemotherapy With or Without Tetanus Toxoid Compared With Chemotherapy Alone in Treating Patients With Metastatic Colorectal Cancer

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Herbert Irving Comprehensive Cancer Center
Study ID
NCT00027833
Phase
PHASE2
Status
Unknown

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • ALVAC-CEA-B7.1 vaccine — BIOLOGICAL
  • tetanus toxoid — BIOLOGICAL
  • FOLFIRI regimen — DRUG
  • fluorouracil — DRUG
  • irinotecan hydrochloride — DRUG
  • leucovorin calcium — DRUG

Study Details

RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Tetanus toxoid may make tumor cells more sensitive to chemotherapy and vaccine therapy. PURPOSE: Randomized phase II trial to study the effectiveness of chemotherapy and vaccine therapy with or without tetanus toxoid compared with chemotherapy alone in treating patients who have metastatic colorectal cancer.

Key Dates

Start date
Dec 31, 2001
Status verified
Sep 2003

Study Design

Allocation
RANDOMIZED
Primary purpose
TREATMENT

Locations (10)

FacilityCityStateZIPSite coordinators
University of Alabama at Birmingham Comprehensive Cancer CenterBirminghamAlabama35243-
USC/Norris Comprehensive Cancer Center and HospitalLos AngelesCalifornia90033-0804-
Lombardi Cancer CenterWashington D.C.District of Columbia20007-
H. Lee Moffitt Cancer Center and Research InstituteTampaFlorida33612-9497-
Robert H. Lurie Comprehensive Cancer Center, Northwestern UniversityChicagoIllinois60611-
University of Chicago Cancer Research CenterChicagoIllinois60637-1470-
Herbert Irving Comprehensive Cancer CenterNew YorkNew York10032-
Earle A. Chiles Research Institute at Providence Portland Medical CenterPortlandOregon97213-2967-
Fox Chase Cancer CenterPhiladelphiaPennsylvania19111-
Scranton Hematology-OncologyScrantonPennsylvania18510-

Find similar trials in Birmingham, AL

By condition
Colorectal cancer
By specialty
OncologyGI oncology
By research site
University of Alabama at Birmingham Comprehensive Cancer Center· Birmingham, ALUSC/Norris Comprehensive Cancer Center and Hospital· Los Angeles, CALombardi Cancer Center· Washington D.C., DCH. Lee Moffitt Cancer Center and Research Institute· Tampa, FLRobert H. Lurie Comprehensive Cancer Center, Northwestern University· Chicago, ILUniversity of Chicago Cancer Research Center· Chicago, IL

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