Oxaliplatin and Bevacizumab (Avastin™) With Either Fluorouracil and Leucovorin or Capecitabine in Treating Patients With Advanced Colorectal Cancer

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Prologue Research International
Study ID
NCT00062426
Phase
PHASE3
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • bevacizumab — BIOLOGICAL
  • capecitabine — DRUG
  • fluorouracil — DRUG
  • leucovorin calcium — DRUG
  • oxaliplatin — DRUG

Study Details

RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, fluorouracil, leucovorin, and capecitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving them in different combinations may kill more tumor cells. Monoclonal antibodies, such as bevacizumab (Avastin™), can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or deliver cancer-killing substances to them. It is not yet known which regimen works better in treating advanced colorectal cancer. PURPOSE: This randomized phase III trial is to see if oxaliplatin and bevacizumab work better when combined with either fluorouracil and leucovorin or capecitabine in treating patients who have metastatic or recurrent colorectal cancer.

Key Dates

First listed
Jun 6, 2003
Start date
May 31, 2003
Status verified
Apr 2004
Completion
Feb 28, 2011

Study Design

Allocation
RANDOMIZED
Primary purpose
TREATMENT

Locations (52)

FacilityCityStateZIPSite coordinators
University of Alabama at Birmingham Comprehensive Cancer CenterBirminghamAlabama35294-3300-
Arizona Clinical Research CenterTucsonArizona85712-
California Cancer Care, Inc.GreenbraeCalifornia94904-2007-
Valley Tumor Medical GroupLancasterCalifornia93534-
Cancer and Blood Institute of the DesertRancho MirageCalifornia92270-
Rocky Mountain Cancer Centers - MidtownDenverColorado80218-
Northwestern Connecticut Oncology-Hematology AssociatesTorringtonConnecticut06790-
Lombardi Cancer Center at Georgetown University Medical CenterWashington D.C.District of Columbia20007-
Lynn Regional Cancer Center WestBoca RatonFlorida33428-
Florida Cancer SpecialistsFort MyersFlorida33901-
Florida Oncology AssociatesJacksonvilleFlorida32207-
Hematology and Oncology Consultants, P.A.OrlandoFlorida32804-
Hematology Oncology Associates of theTreasure Coast - Port St. LuciePort Saint LucieFlorida34952-
Palm Beach Cancer InstituteWest Palm BeachFlorida33401-
Peachtree Hematology and Oncology Consultants, P.C.AtlantaGeorgia30309-
North Idaho Cancer CenterCoeur d'AleneIdaho83814-
Robert H. Lurie Comprehensive Cancer Center at Northwestern UniversityChicagoIllinois60611-
Lutheran General Cancer Care CenterPark RidgeIllinois60068-1270-
West Suburban Center for Cancer CareRiver ForestIllinois60305-
Saint Anthony Medical CenterRockfordIllinois61108-
CCOP - Northern Indiana CR ConsortiumSouth BendIndiana46601-
Cedar Rapids Oncology AssociatesCedar RapidsIowa52403-1206-
CCOP - WichitaWichitaKansas67214-3882-
Greater Baltimore Medical Center and Cancer CenterBaltimoreMaryland21204-
Jackson Oncology Associates, PLLCJacksonMississippi39202-
Veterans Affairs Medical Center - Kansas CityKansas CityMissouri64128-
Deaconess Billings Clinic Cancer CenterBillingsMontana59107-5100-
Cooper Cancer Institute at Cooper University HospitalVoorhees TownshipNew Jersey08043-
Advanced Oncology AssociatesArmonkNew York10504-
North Shore Hematology/Oncology Associates, P.C.East SetauketNew York11733-
Arena Oncology AssociatesGreat NeckNew York11021-
New York University Medical CenterNew YorkNew York10016-
St. Vincents Comprehensive Cancer CenterNew YorkNew York10011-
New York Medical CollegeValhallaNew York10595-
Duke Comprehensive Cancer CenterDurhamNorth Carolina27710-
Southeastern Medical Oncology CenterGoldsboroNorth Carolina27534-
Physicians East - QuadrangleGreenvilleNorth Carolina27834-
Raleigh Hematology/Oncology Associates, P.A. - Wake PracticeRaleighNorth Carolina27609-7300-
Hematology Oncology Consultants IncColumbusOhio43235-
Hematology/Oncology of SalemSalemOregon97301-
Pennsylvania Oncology Hematology AssociatesPhiladelphiaPennsylvania19106-
Hillman Cancer Center at University of Pittsburgh Cancer InstitutePittsburghPennsylvania15232-
Charleston Hematology-Oncology, P.A.CharlestonSouth Carolina29403-
McCleod Cancer and Blood CenterJohnson CityTennessee37604-
Memphis Cancer CenterMemphisTennessee38119-
West ClinicMemphisTennessee38120-
Sarah Cannon Cancer Center at Centennial Medical CenterNashvilleTennessee37203-
Lone Star OncologyAustinTexas78759-
Medical City Dallas HospitalDallasTexas75230-
South Texas Oncology and HematologySan AntonioTexas78207-
Center for Cancer Prevention and Care at Scott and White ClinicTempleTexas76508-
Medical ConsultantsMilwaukeeWisconsin53215-3690-

Find similar trials in Birmingham, AL

By condition
Colorectal cancer
By specialty
OncologyGI oncology
By research site
University of Alabama at Birmingham Comprehensive Cancer Center· Birmingham, ALArizona Clinical Research Center· Tucson, AZCalifornia Cancer Care, Inc.· Greenbrae, CAValley Tumor Medical Group· Lancaster, CACancer and Blood Institute of the Desert· Rancho Mirage, CARocky Mountain Cancer Centers - Midtown· Denver, CO

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