Erlotinib + Bevacizumab for PS 2 Chemotherapy Naïve Non-Small Cell Lung Cancer

Part of paid clinical trials in Galesburg, Illinois.

Sponsor
Nasser Hanna, M.D.
Study ID
NCT00367601
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The strategy for combining therapeutic agents in cancer treatments has been successful in multiple tumor types, including NSCLC. Erlotinib and bevacizumab target different pathways involved in tumor growth. Nonclinical studies have demonstrated that the combination of bevacizumab and erlotinib results in greater efficacy than either agent alone. Furthermore, because there is little to no overlap in toxicity profile between the two agents, the combination is expected to be well tolerated and may provide even greater benefit for patients who are unable to receive cytotoxic therapy.

Key Dates

First listed
Aug 23, 2006
Start date
Aug 31, 2006
Status verified
Jan 2016
Primary completion
Apr 30, 2008
Completion
Dec 31, 2008

Study Design

Enrollment
25 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: 1
    Bevacizumab + erlotinib; if no progressive disease observed, combination or single-agent treatment will continue until unacceptable toxicity or progressive disease.

Primary Outcome Measure

To Establish Rate of Non-progressive Disease at 4 Months in Patients With Advanced NSCLC Who Have Been Designated PS2 by Their Treating Physician [ Time Frame: 4 months ]

Locations (13)

FacilityCityStateZIPSite coordinators
Medical & Surgical Specialists, LLCGalesburgIllinois61401-
Cancer Care Center of Southern IndianaBloomingtonIndiana47403-
Oncology Hematology Associates of SW IndianaEvansvilleIndiana47714-
Fort Wayne Oncology & Hematology, IncFort WayneIndiana46815-
Community Regional Cancer CenterIndianapolisIndiana46256-
Indiana University Cancer CenterIndianapolisIndiana46202-
Quality Cancer Center (MCGOP)IndianapolisIndiana46202-
Arnett Cancer CareLafayetteIndiana47904-
Horizon Oncology CenterLafayetteIndiana47905-
Medical Consultants, P.C.MuncieIndiana47303-
Northern Indiana Cancer Research ConsortiumSouth BendIndiana46601-
Methodist Cancer CenterOmahaNebraska68114-
Oncology Partners NetworkCincinnatiOhio45247-

Find similar trials in Galesburg, IL

By condition
Lung cancer
By specialty
OncologyLung oncologyLung disease
By research site
Medical & Surgical Specialists, LLC· Galesburg, ILCancer Care Center of Southern Indiana· Bloomington, INOncology Hematology Associates of SW Indiana· Evansville, INFort Wayne Oncology & Hematology, Inc· Fort Wayne, INCommunity Regional Cancer Center· Indianapolis, INIndiana University Cancer Center· Indianapolis, IN

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