Effects of Dapagliflozin on Kidney Function (Glomerular Filtration Rate) in Subjects With Type 2 Diabetes

Part of paid clinical trials in Anaheim, California.

Sponsor
AstraZeneca
Study ID
NCT00976495
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Dapagliflozin — DRUG
    Tablets, Oral, 10 mg, once daily, 12 weeks
  • Placebo — DRUG
    Tablets, Oral, 0 mg, once daily, 12 weeks
  • Hydrochlorothiazide — DRUG
    Tablets, Oral, 25 mg, once daily, 12 weeks

Study Details

The purpose of this study is to evaluate the effects of dapagliflozin on kidney function, as assessed by glomerular filtration rate.

Key Dates

Start date
Oct 31, 2009
Status verified
Jan 2017
Primary completion
Nov 30, 2010
Completion
Nov 30, 2010

Study Design

Enrollment
154 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Dapagliflozin
  • Active Comparator: Hydrochlorothiazide

Primary Outcome Measure

Adjusted Percent Change From Baseline in Glomerular Filtration Rate (GFR) at Week 12 (Modified Last Observation Carried Forward [MLOCF]) [ Time Frame: From Baseline to Week 12 ]

Locations (9)

FacilityCityStateZIPSite coordinators
Advanced Clinical Res InstAnaheimCalifornia92801-
Torrance Clinical ResearchLomitaCalifornia90717-
Elite Research InstituteMiamiFlorida33169-
Compass Research, LlcOrlandoFlorida32806-
Orlando Clinical Research CenterOrlandoFlorida32809-
University Of MichiganAnn ArborMichigan48106-
Prism ResearchSaint PaulMinnesota55114-
Memorial Hospital Of Rhode IslandPawtucketRhode Island02860-
Zablocki Veterans Affairs Medical CenterMilwaukeeWisconsin53295-

Find similar trials in Anaheim, CA

By condition
Type 2 diabetes
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Advanced Clinical Res Inst· Anaheim, CATorrance Clinical Research· Lomita, CAElite Research Institute· Miami, FLCompass Research, Llc· Orlando, FLOrlando Clinical Research Center· Orlando, FLUniversity Of Michigan· Ann Arbor, MI

Related Studies