Randomized Clinical Trial of Intravitreal Bevacizumab Versus Intravitreal Bevacizumab Combined With Losartan in the Treatment of Diabetic Macular Edema

Sponsor
Tehran University of Medical Sciences
Study ID
NCT02663141
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The aim of this study is to determine whether oral losartan is effective in the treatment of diabetic macular edema (DME) as an adjuvant for intravitreal bevacizumab (IVB).

Key Dates

First listed
Jan 26, 2016
Start date
Jun 30, 2015
Status verified
Jul 2016
Primary completion
Jun 30, 2016
Completion
Jun 30, 2016

Study Design

Enrollment
57 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Losartan
    Oral losartan 50 mg daily for 6 months
  • Placebo Comparator: Placebo
    Oral placebo daily for 6 months

Primary Outcome Measure

difference in ETDRS best-corrected visual acuity (BCVA) between arms [ Time Frame: Within 6 months from therapy ]

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