Pharmacokinetic/Pharmacodynamic Drug-drug Interaction of Evogliptin 5 mg and Pioglitazone 30 mg
- Sponsor
- Dong-A ST Co., Ltd.
- Study ID
- NCT02753803
- Phase
- PHASE1
- Status
- Completed
Conditions
Eligibility Criteria
- Sex
- MALE
- Age
- 19 Years - 45 Years
- Healthy Volunteers
- Accepted
Interventions
- Evogliptin, Pioglitazone, Evogliptin+Pioglitazone — DRUGEvogliptin : Evogliptin 5mg QD Pioglitazone : Pioglitazone 30mg QD Evogliptin+Pioglitazone : Evogliptin 5mg QD + Pioglitazone 30mg QD
- Pioglitazone, Evogliptin, Evogliptin+Pioglitazone — DRUGPioglitazone : Pioglitazone 30mg QD Evogliptin : Evogliptin 5mg QD Evogliptin+Pioglitazone : Evogliptin 5mg QD + Pioglitazone 30mg QD
- Evogliptin, Evogliptin+Pioglitazone, Pioglitazone — DRUGEvogliptin : Evogliptin 5mg QD Evogliptin+Pioglitazone : Evogliptin 5mg QD + Pioglitazone 30mg QD Pioglitazone : Pioglitazone 30mg QD
- Pioglitazone, Evogliptin+Pioglitazone, Evogliptin — DRUGPioglitazone : Pioglitazone 30mg QD Evogliptin+Pioglitazone : Evogliptin 5mg QD + Pioglitazone 30mg QD Evogliptin : Evogliptin 5mg QD
- Evogliptin+Pioglitazone, Evogliptin, Pioglitazone — DRUGEvogliptin+Pioglitazone : Evogliptin 5mg QD + Pioglitazone 30mg QD Evogliptin : Evogliptin 5mg QD Pioglitazone : Pioglitazone 30mg QD
- Evogliptin+Pioglitazone, Pioglitazone, Evogliptin — DRUGEvogliptin+Pioglitazone : Evogliptin 5mg QD + Pioglitazone 30mg QD Pioglitazone : Pioglitazone 30mg QD Evogliptin : Evogliptin 5mg QD
Study Details
A randomized, open-label, multiple dosing, three-way crossover clinical trial to investigate the pharmacokinetic/pharmacodynamic drug-drug interaction of evogliptin 5 mg and pioglitazone 30 mg after oral administration in healthy male subjects
Key Dates
- First listed
- Apr 28, 2016
- Start date
- Jul 27, 2016
- Status verified
- Sep 2017
- Primary completion
- Oct 19, 2016
- Completion
- Mar 10, 2017
Study Design
- Enrollment
- 36 participants (actual)
- Allocation
- RANDOMIZED
- Intervention model
- CROSSOVER
- Primary purpose
- HEALTH_SERVICES_RESEARCH
Arms
- Experimental: A groupEvogliptin Pioglitazone Evogliptin+Pioglitazone
- Experimental: B groupPioglitazone Evogliptin Evogliptin+Pioglitazone
- Experimental: C groupEvogliptin Evogliptin+Pioglitazone Pioglitazone
- Experimental: D groupPioglitazone Evogliptin+Pioglitazone Evogliptin
- Experimental: E groupEvogliptin+Pioglitazone Evogliptin Pioglitazone
- Experimental: F groupEvogliptin+Pioglitazone Pioglitazone Evogliptin
Primary Outcome Measure
AUC [ Time Frame: 1d~6d pre-dose, 15d~20d pre-dose, 29~34d pre-dose, 7d/21d/35d pre-dose and post-dose ]
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