Immune-Competent Cell Manifestations in Psoriatic Arthritis Achilles Tendons

Sponsor
Odense University Hospital
Study ID
NCT03248284
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Tendon biopsy procedure — PROCEDURE
    Two tendon biopsy specimens will be obtained from one Achilles tendon with enthesitis.

Study Details

Tendon pathologies (enthesitis) are a characteristic component of psoriatic arthritis (PsA), and are observed in 35% to 50% of PsA patients. The Achilles tendon is one of the most commonly affected sites. This condition often causes great morbidity and loss of quality of life, and response only suboptimal to current intervention strategies. One of the main obstacles for the development of effective treatment methods is that the disease mechanisms remain poorly understood. To our knowledge, no one has yet ascertained the presence and function of immune-competent cells and inflammatory markers in tendons tissue from PsA patients suffering from Achilles enthesitis.

Key Dates

First listed
Aug 14, 2017
Start date
Aug 21, 2017
Status verified
Mar 2025
Primary completion
Dec 31, 2026
Completion
Mar 31, 2027

Study Design

Enrollment
30 participants (estimated)

Primary Outcome Measure

Presence of Immune-competent cells and inflammatory markers [ Time Frame: Baseline ]

Central Contacts

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Psoriatic arthritis trialsRheumatology trialsAutoimmune disease trialsMusculoskeletal disorders trials

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