Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention

Sponsor
Chinese University of Hong Kong
Study ID
NCT03875625
Status
Recruiting
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Conditions

  • Abdominal Subcutaneous Fat
  • Brown Fat
  • Diabetes Mellitus
  • Insulin Resistance
  • Metabolic Disease
  • Non-Alcoholic Fatty Liver Disease
  • Obesity, Morbid

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Bariatric surgery — PROCEDURE
    Use of the normal bariatric surgery procedures commonly conducted in our hospital, such as: Laparoscopic Roux-en-Y gastric bypass (RYGB) and Laparoscopic sleeve gastrectomy (LSG)
  • Dietitian led life style modification intervention — BEHAVIORAL
    Intensive 6 months life style changes supervised by diatitians.
  • Conventional care (control) — BEHAVIORAL
    receive routine care

Study Details

The study is aimed * To quantify the change of adipose tissues, triglyceride in liver and pancreas and cholesterol after lifestyle intervention or bariatric surgery. * To test the hypothesis that Brown fat is an independent biomarker for the development of Non Alcoholic Fat Liver Disease (NAFLD) * To study the association among Brown fat, NAFLD and obesity.

Key Dates

First listed
Mar 15, 2019
Start date
Apr 1, 2019
Status verified
Feb 2025
Primary completion
Dec 31, 2025
Completion
Jun 30, 2026

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Morbid obesity- Bariatric surgery group
    Morbid obese subjects who will consent to bariatric surgery
  • Experimental: Morbid obesity-Dietitian led life style intervention group
    Morbid obese subjects who will not consent to bariatric surgery but instead opt for dietitian led life style intervention
  • Experimental: Mild obesity-Dietitian led life style intervention group
    Mild- Moderate subjects assigned through a randomized controlled trial to the dietitian led life style intervention
  • Experimental: Mild obesity-Conventional care group (control)
    Mild- Moderate subjects assigned through a randomized controlled trial to conventional care

Primary Outcome Measure

Use of modified Dixon Magnetic Resonance Imaging method to measure the response of adipose tissue in different organs following life style modification program or Bariatric surgery [ Time Frame: one year ]

Central Contacts

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