IL-6 Regulation of Substrate Metabolism and Influence of Obesity

Sponsor
Rigshospitalet, Denmark
Study ID
NCT03967691
Status
Completed

Conditions

Eligibility Criteria

Sex
MALE
Age
18 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

  • Tocilizumab infusion — DRUG
    Tocilizumab (8mg/kg body weight diluted to 100 ml NaCl 0.9%) will be infused over 1 hour
  • Saline 0.9% — DRUG
    100 ml NaCl 0.9% will be infused over 1 hour

Study Details

The aim of the study is to investigate the effects of blocking IL-6 signaling with tocilizumab on lipid, glucose and protein metabolism during rest and exercise in healthy and obese humans. Interleukin-6 is a molecule produced by a variety of cells and impacts on energy metabolism during fasting and fed conditions. Systemic IL-6 levels are low but increase acutely in response to fasting, exercise and infection, and also chronically in response to obesity and other conditions of lowgrade inflammation.Our recent human intervention study showed that IL-6 receptor blockade prevents exercise training from reducing visceral fat mass. Whether IL-6 receptor blockade directly regulates lipolysis and/or lipid oxidation in humans is however unclear. Therefore, this study will be performed to investigate the physiological role of IL-6 on lipid, glucose and protein metabolism in humans.

Key Dates

Start date
Jun 12, 2019
Status verified
Oct 2020
Primary completion
Apr 3, 2020
Completion
Apr 3, 2020

Study Design

Enrollment
22 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: Saline infusion
    Subjects will be infused with saline (placebo) on study day 1
  • Active Comparator: Tocilizumab infusion
    Subjects will be infused with tocilizumab on study day 2
  • Other: Saline infusion under tocilizumab influence
    Subjects will be infused withsaline (but still under the influence of tocilizumab) on study day 3

Primary Outcome Measure

Lipolytic rate [ Time Frame: 0-28 days ]

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