Patient-Derived Xenografts to Reduce Cancer Health Disparities

Part of paid clinical trials in Orange, California.

Sponsor
University of California, Davis
Study ID
NCT04410302
Status
Recruiting
Apply to this trial

Conditions

  • Bladder Carcinoma
  • Gastric Carcinoma
  • Liver and Intrahepatic Bile Duct Carcinoma
  • Lung Carcinoma
  • Malignant Neoplasm

Eligibility Criteria

Sex
ALL
Age
21 Years - 100 Years
Healthy Volunteers
Not accepted

Interventions

  • Biospecimen Collection — PROCEDURE
    Undergo collection of tumor tissue, blood, saliva, and urine samples

Study Details

This trial establishes patient-derived cancer xenografts in addressing cancer health and treatment disparities that disproportionately affect racial/ethnic minorities. Understanding the genetic and response differences among racial/ethnic minorities may help researchers enhance the precision of therapeutic treatments.

Key Dates

First listed
Jun 1, 2020
Start date
Nov 12, 2019
Status verified
Jul 2026
Primary completion
Dec 31, 2026
Completion
Jun 30, 2027

Study Design

Enrollment
500 participants (estimated)

Arms

  • Arm: Ancillary-correlative (biospecimen collection)
    Patients undergo collection of tumor tissue samples during standard of care tumor biopsy or surgical resection to establish PDXs. Patients may also undergo collection of blood, saliva, and urine samples to compare DNA abnormalities to noncancer cells in order to determine if they were present before the cancer started or developed with it.

Primary Outcome Measure

Establish and characterize at least 200 patient-derived cancer xenografts (PDXs) [ Time Frame: Up to 4 years ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
UC Irvine Health/Chao Family Comprehensive Cancer CenterOrangeCalifornia92868
Marian Waterman
[email protected]
949-824-2885
Marian Waterman (PRINCIPAL_INVESTIGATOR)
University of California Davis Comprehensive Cancer CenterSacramentoCalifornia95817
Luis G. Carvajal-Carmona
[email protected]
530-752-9654
Luis G. Carvajal-Carmona (PRINCIPAL_INVESTIGATOR)

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By research site
UC Irvine Health/Chao Family Comprehensive Cancer Center· Orange, CAUniversity of California Davis Comprehensive Cancer Center· Sacramento, CA

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