Regulation of Muscle Protein Phenotype in Humans With Obesity

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
Mayo Clinic
Study ID
NCT04700800
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Exercise — OTHER
    Exercise at 65% of heart rate reserve

Study Details

A hallmark of muscle changes in obesity is an altered muscle fiber type profile, characterized by a reduced proportion of Type I fibers - a shift associated with adverse obesity-related health outcomes. This alteration can be linked to changes in the expression of myosin heavy chain (MHC) protein isoforms in the skeletal muscle of individuals with obesity. The investigators aim to modulate the metabolism of muscle MHC isoforms to uncover the biological mechanisms underlying this disrupted expression pattern in muscle of humans with obesity.

Key Dates

Start date
Oct 7, 2021
Status verified
Sep 2025
Primary completion
Oct 2, 2024
Completion
Oct 2, 2024

Study Design

Enrollment
48 participants (actual)
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Subjects with obesity
    Exercise followed by infusion of amino acids
  • Active Comparator: Lean Subjects
    Exercise followed by infusion of amino acids

Primary Outcome Measure

Whole-Muscle Protein Synthesis [ Time Frame: 9 Hours ]

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic in ArizonaScottsdaleArizona85259-

Find similar trials in Scottsdale, AZ

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Mayo Clinic in Arizona· Scottsdale, AZ

Related Studies