Cytokine Expression in Psoriasis Patients With and Without Joint Involvement

Sponsor
Poitiers University Hospital
Study ID
NCT05307809
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Accepted

Interventions

  • Blood sample collection — OTHER
    Blood sample collection
  • Skin sample collection — OTHER
    Skin sample collection

Study Details

The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution of cytokines to the presence or absence of joint involvement. This research will compare cytokines levels in sera, in PBMC culture after LPS or CD3/CD28 agonist antibodies, and in skin biopsy.

Key Dates

First listed
Apr 1, 2022
Start date
Aug 17, 2022
Status verified
May 2026
Primary completion
Aug 17, 2026
Completion
Aug 18, 2026

Study Design

Enrollment
40 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Psoriasis
  • Experimental: Psoriatic arthritis
  • Active Comparator: Controls

Primary Outcome Measure

Comparison of cytokine levels in sera, after culture of PBMC stimulated with LPS or CD3/CD28 agonist antibodies between the three groups [ Time Frame: At inclusion ]

Central Contacts

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