A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT05882045
Phase
PHASE3
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Retatrutide — DRUG
    Administered SC
  • Placebo — DRUG
    Administered SC

Study Details

The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants with obesity and established cardiovascular disease (CVD). The study will last about 113 weeks.

Key Dates

First listed
May 31, 2023
Start date
May 30, 2023
Status verified
Jul 2026
Primary completion
Apr 16, 2026
Completion
May 14, 2026

Study Design

Enrollment
1,946 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Retatrutide Dose 1
    Participants will receive retatrutide subcutaneously (SC).
  • Experimental: Retatrutide Dose 2
    Participants will receive retatrutide SC.
  • Placebo Comparator: Placebo
    Participants will receive placebo.

Primary Outcome Measure

Percent Change from Baseline in Body Weight [ Time Frame: Baseline, Week 80 ]

Locations (46)

FacilityCityStateZIPSite coordinators
Central Phoenix Medical ClinicPhoenixArizona85020-
Valley Clinical Trials, Inc.CovinaCalifornia91723-
Neuro-Pain Medical CenterFresnoCalifornia93710-
Valley ResearchFresnoCalifornia93720-
Collaborative Neuroscience Research, LLCLos AlamitosCalifornia90720-
Velocity Clinical Research, WestlakeLos AngelesCalifornia90057-
Valley Clinical Trials, Inc.NorthridgeCalifornia91325-
Velocity Clinical Research, Panorama CityVan NuysCalifornia91405-
Chase Medical Research, LLCWaterburyConnecticut06708-
Indago Research & Health Center, IncHialeahFlorida33012-
Clinical Neuroscience Solutions, Inc. dba CNS HealthcareJacksonvilleFlorida32256-
Charter Research - Winter ParkOrlandoFlorida32803-
Clinical Neuroscience Solutions, Inc.OrlandoFlorida32801-
Progressive Medical ResearchPort OrangeFlorida32127-
Pacific Diabetes & Endocrine CenterHonoluluHawaii96817-
Elite Clinical TrialsBlackfootIdaho83221-
Humphreys Diabetes CenterBoiseIdaho83702-
Northwestern UniversityChicagoIllinois60611-
Great Lakes Clinical Trials - GurneeGurneeIllinois60031-
Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research CooperativeSpringfieldIllinois62711-
Brengle Family MedicineIndianapolisIndiana46260-
Iowa Diabetes and Endocrinology Research CenterWest Des MoinesIowa50265-
Cotton O'Neil Diabetes & EndocrinologyTopekaKansas66606-
MedVadis Research CorporationWalthamMassachusetts02451-
StudyMetrix ResearchCity of Saint PetersMissouri63303-
Las Vegas Medical ResearchLas VegasNevada89128-
Palm Research Center TenayaLas VegasNevada89128-
IMA Clinical Research WarrenWarren TownshipNew Jersey07059-
Weill Cornell Medical CollegeNew YorkNew York10021-
Rochester Clinical Research, LLCRochesterNew York14609-
Carteret Medical GroupMorehead CityNorth Carolina28557-
Cleveland ClinicClevelandOhio44195-
Altoona Center For Clinical ResearchDuncansvillePennsylvania16635-
UPMC Montefiore University HospitalPittsburghPennsylvania15213-
Tribe Clinical Research, LLCGreenvilleSouth Carolina29607-
Trial Management AssociatesMyrtle BeachSouth Carolina29572-
Tribe Clinical Research - SpartanburgSpartanburgSouth Carolina29301-
Pinnacle Clinical ResearchAustinTexas78757-
Texas Diabetes & Endocrinology, P.A.AustinTexas78731-
South Texas Clinical ResearchCorpus ChristiTexas78404-
Southern Endocrinology AssociatesMesquiteTexas75149-
Texas Diabetes & Endocrinology, P.A.Round RockTexas78681-
Sleep Therapy Research CenterSan AntonioTexas78229-
Consano Clinical Research, LLCShavano ParkTexas78231-
Advanced Research InstituteOgdenUtah84405-
Rainier Clinical Research CenterRentonWashington98057-

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By research site
Central Phoenix Medical Clinic· Phoenix, AZValley Clinical Trials, Inc.· Covina, CANeuro-Pain Medical Center· Fresno, CAValley Research· Fresno, CACollaborative Neuroscience Research, LLC· Los Alamitos, CAVelocity Clinical Research, Westlake· Los Angeles, CA

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