A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT05882045
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Retatrutide — DRUG
    Administered SC
  • Placebo — DRUG
    Administered SC

Study Details

The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants with obesity and established cardiovascular disease (CVD). The study will last about 113 weeks.

Key Dates

Start date
May 30, 2023
Status verified
May 2026
Primary completion
Apr 16, 2026
Completion
May 31, 2026

Study Design

Enrollment
1,946 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Retatrutide Dose 1
    Participants will receive retatrutide subcutaneously (SC).
  • Experimental: Retatrutide Dose 2
    Participants will receive retatrutide SC.
  • Placebo Comparator: Placebo
    Participants will receive placebo.

Primary Outcome Measure

Percent Change from Baseline in Body Weight [ Time Frame: Baseline, Week 80 ]

Locations (46)

FacilityCityStateZIP
Central Phoenix Medical ClinicPhoenixArizona85020
Valley Clinical Trials, Inc.CovinaCalifornia91723
Neuro-Pain Medical CenterFresnoCalifornia93710
Valley ResearchFresnoCalifornia93720
Collaborative Neuroscience Research, LLCLos AlamitosCalifornia90720
Velocity Clinical Research, WestlakeLos AngelesCalifornia90057
Valley Clinical Trials, Inc.NorthridgeCalifornia91325
Velocity Clinical Research, Panorama CityVan NuysCalifornia91405
Chase Medical Research, LLCWaterburyConnecticut06708
Indago Research & Health Center, IncHialeahFlorida33012
Clinical Neuroscience Solutions, Inc. dba CNS HealthcareJacksonvilleFlorida32256
Charter Research - Winter ParkOrlandoFlorida32803
Clinical Neuroscience Solutions, Inc.OrlandoFlorida32801
Progressive Medical ResearchPort OrangeFlorida32127
Pacific Diabetes & Endocrine CenterHonoluluHawaii96817
Elite Clinical TrialsBlackfootIdaho83221
Humphreys Diabetes CenterBoiseIdaho83702
Northwestern UniversityChicagoIllinois60611
Great Lakes Clinical Trials - GurneeGurneeIllinois60031
Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research CooperativeSpringfieldIllinois62711
Brengle Family MedicineIndianapolisIndiana46260
Iowa Diabetes and Endocrinology Research CenterWest Des MoinesIowa50265
Cotton O'Neil Diabetes & EndocrinologyTopekaKansas66606
MedVadis Research CorporationWalthamMassachusetts02451
StudyMetrix ResearchCity of Saint PetersMissouri63303
Las Vegas Medical ResearchLas VegasNevada89128
Palm Research Center TenayaLas VegasNevada89128
IMA Clinical Research WarrenWarren TownshipNew Jersey07059
Weill Cornell Medical CollegeNew YorkNew York10021
Rochester Clinical Research, LLCRochesterNew York14609
Carteret Medical GroupMorehead CityNorth Carolina28557
Cleveland ClinicClevelandOhio44195
Altoona Center For Clinical ResearchDuncansvillePennsylvania16635
UPMC Montefiore University HospitalPittsburghPennsylvania15213
Tribe Clinical Research, LLCGreenvilleSouth Carolina29607
Trial Management AssociatesMyrtle BeachSouth Carolina29572
Tribe Clinical Research - SpartanburgSpartanburgSouth Carolina29301
Pinnacle Clinical ResearchAustinTexas78757
Texas Diabetes & Endocrinology, P.A.AustinTexas78731
South Texas Clinical ResearchCorpus ChristiTexas78404
Southern Endocrinology AssociatesMesquiteTexas75149
Texas Diabetes & Endocrinology, P.A.Round RockTexas78681
Sleep Therapy Research CenterSan AntonioTexas78229
Consano Clinical Research, LLCShavano ParkTexas78231
Advanced Research InstituteOgdenUtah84405
Rainier Clinical Research CenterRentonWashington98057

Related coverage on Hipa.ai

Find similar trials in Phoenix, AZ

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Central Phoenix Medical Clinic· Phoenix, AZValley Clinical Trials, Inc.· Covina, CANeuro-Pain Medical Center· Fresno, CAValley Research· Fresno, CACollaborative Neuroscience Research, LLC· Los Alamitos, CAVelocity Clinical Research, Westlake· Los Angeles, CA

Related Studies