A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight

Conditions

• Obesity
• Obstructive Sleep Apnea
• Osteoarthritis, Knee
• Overweight

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Retatrutide — DRUG
  Administered SC
• Placebo — DRUG
  Administered SC

Study Details

The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA) (J1I-MC-GOA1) or who have obstructive sleep apnea (OSA) (J1I-MC-GSA1). This study will last about 89 weeks and will include up to 24 visits. Addendum (2) is optional and available to approximately 500 participants to continue treatment with retatrutide for up to an additional 24 weeks.

Key Dates

Start date

Jul 10, 2023

Status verified

Jun 2026

Primary completion

Apr 6, 2026

Completion

Apr 30, 2026

Study Design

Enrollment

2,335 participants (actual)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Retatrutide Dose 1
  Participants will receive retatrutide subcutaneously (SC).
• Experimental: Retatrutide Dose 2
  Participants will receive retatrutide SC.
• Experimental: Retatrutide Dose 3
  Participants will receive retatrutide SC.
• Placebo Comparator: Placebo
  Participants will receive placebo.
• Experimental: Retatrutide Extension Period
  Participants will receive retatrutide after the placebo-controlled 80 week treatment period for an additional 24 weeks.

Primary Outcome Measure

Percent Change From Baseline in Body Weight [ Time Frame: Baseline, Week 80 ]

Locations (39)

Related coverage on Hipa.ai

• Retatrutide Phase 3 Trial for Obesity and Overweight Completes Primary Study
  Retatrutide · Apr 30, 2026 · ClinicalTrials.gov

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