Effect of Genetic Polymorphisms on the Clinical Response to SGLT2 Inhibitors in Heart Failure Patients

Part of paid clinical trials in Gainesville, Florida.

Sponsor
October 6 University
Study ID
NCT06201000
Status
Unknown

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

Study Details

Sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown further reductions in heart failure hospitalization, cardiovascular events, and mortality, especially for heart failure patients. The SGLT2 gene, also known as SLC5A2 (solute carrier family 5 member 2), is located on chromosome 16 and is responsible for encoding SGLT2. Several SLC5A2 mutations alter SGLT2 expression, membrane location, or transporter function. Several common genetic variations were found in the SLC5A2 gene that may affect the response to treatment with SGLT2 inhibitors.

Key Dates

Start date
Dec 27, 2023
Status verified
Feb 2024
Primary completion
Jul 1, 2024
Completion
Sep 1, 2024

Study Design

Enrollment
282 participants (estimated)

Arms

  • Arm: Heart Failure Patients with reduced or preserved Ejection Fraction
    Patients with reduced or preserved ejection fraction that have received the Guided Therapy (β-blockers, Diuretics, Angiotensin-converting enzyme (ACE) inhibitors or Angiotensin receptor blockers (ARBs) or Angiotensin Receptor-Neprilysin Inhibitor (ARNi) and Mineralocorticoid receptor antagonists (MRAs) then Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) (10 mg of dapagliflozin or empagliflozin) will be added at the study entry.

Primary Outcome Measure

Median / Mean of Left Ventricular Ejection Fraction (LVEF) among studied genetic polymorphisms [ Time Frame: 6 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of FloridaGainesvilleFlorida32610
Julio Duarte, PhD

Find similar trials in Gainesville, FL

By condition
Heart failure
By specialty
CardiologyHeart disease
By research site
University of Florida· Gainesville, FL

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