Identification of Cutaneous and Blood Biomarkers Predictive of Response to Systemic Treatments During Chronic Inflammatory Skin Diseases

Sponsor
Assistance Publique - Hôpitaux de Paris
Study ID
NCT06599411
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Sampling — OTHER
    Collection of an additional volume of blood, Superficial skin biopsy, Skin swab, Hair follicle, Stool,
  • Sampling — OTHER
    Collection of an additional volume of blood, Preservation of post-operative skin remnants, Skin swab, Hair follicle, Stool

Study Details

Chronic inflammatory skin diseases constitute a heterogeneous group of pathologies. They affect the skin but also other organs (joints, lungs, muscles, etc.). Their prognosis and response to treatments is extremely variable. The discovery of prognosis factors will help to precisely guide the treatment regimen and its intensification based on individual markers. The identification of new therapeutic targets is essential to develop new innovative treatments for inflammatory skin diseases. The main objective is to identify new cellular or molecular prognostic factors associated with treatment response at 1 year in inflammatory skin diseases. The secondary objectives are a better understanding of the pathophysiology of chronic inflammatory skin diseases, the identification of new cellular, molecular and microbiological prognostic factors associated with the clinical state after 10 years of evolution and the identification of prognostic markers of drug toxicity.

Key Dates

First listed
Sep 19, 2024
Start date
Oct 20, 2025
Status verified
Jun 2026
Primary completion
Nov 20, 2035
Completion
Oct 20, 2045

Study Design

Enrollment
830 participants (estimated)

Arms

  • Arm: Patients
    Affected by inflammatory skin disease
  • Arm: Controls
    Plastic surgery patients who have had any type of surgery resulting in healthy skin remnants

Primary Outcome Measure

Therapeutic response [ Time Frame: At 1 year ]

Central Contacts

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