A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3)

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Eli Lilly and Company
Study ID
NCT06653153
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
55 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Remternetug — DRUG
    Administered SC
  • Placebo — DRUG
    Administered SC

Study Details

The purpose of this study is to measure the difference in time to developing or worsening memory, thinking, or functional problems due to Alzheimer's disease occurring in participants receiving study drug compared to placebo. Participation could last up to 255 weeks including screening, a double-blind treatment period, and a double-blind observation period. In addition, eligible participants who receive placebo during the double-blind treatment period may choose to extend their study participation to receive open-label remternetug in an extension period.

Key Dates

First listed
Oct 22, 2024
Start date
Oct 24, 2024
Status verified
Nov 2025
Primary completion
Apr 30, 2029
Completion
Oct 31, 2030

Study Design

Enrollment
1,400 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Remternetug
    Remternetug administered subcutaneously (SC).
  • Placebo Comparator: Placebo
    Placebo administered SC.

Primary Outcome Measure

Time to Clinically Meaningful Progression as Measured by Clinical Dementia Rate Scale (CDR) [ Time Frame: Baseline to Time to Event up to Week 255 ]

Locations (123)

FacilityCityStateZIPSite coordinators
Parkway Medical CenterBirminghamAlabama35215-
MD First Research - ChandlerChandlerArizona85286-
Care Access - 801 South Power Road, MesaMesaArizona85206-
Banner Alzheimer's InstitutePhoenixArizona85006-
Banner Alzheimer's Institute TucsonTucsonArizona85718-
Neuro-Pain Medical CenterFresnoCalifornia93710-
Care Access - Huntington BeachHuntington BeachCalifornia92648-
Inglewood ClinicalInglewoodCalifornia90301-
Irvine Clinical ResearchIrvineCalifornia92614-
Healthy Brain ClinicLong BeachCalifornia90804-
Riverside ClinicalRiversideCalifornia92506-
Clinical Trials ResearchSacramentoCalifornia95821-
Artemis Institute for Clinical ResearchSan DiegoCalifornia92103-
Sharp Neurocognitive Research CenterSan DiegoCalifornia92123-
Ray Dolby Brain Health CenterSan FranciscoCalifornia94114-
The Neuron Clinic - San MarcosSan MarcosCalifornia92069-
Syrentis Clinical ResearchSanta AnaCalifornia92705-
Providence Medical FoundationSanta RosaCalifornia95403-
California Neuroscience Research, LLCSherman OaksCalifornia91403-
Care Access - AuroraAuroraColorado80012-
Mountain Neurological Research CenterBasaltColorado81621-
Alpine Clinical Research CenterBoulderColorado80301-
CenExel Rocky Mountain Clinical ResearchEnglewoodColorado80113-
InvicroNew HavenConnecticut06510-
Ki Health Partners, LLc, dba New England Institute for Clinical ResearchStamfordConnecticut06905-
JEM Research InstituteAtlantisFlorida33462-
VIN - AventuraAventuraFlorida33180-
Bradenton Research Center, Inc.BradentonFlorida34205-
K2 Medical Research WINTER GARDENClermontFlorida34711-
TecTum ResearchDavieFlorida33024-
Brain Matters ResearchDelray BeachFlorida33445-
Neuropsychiatric Research Center of Southwest FloridaFort MyersFlorida33912-
Indago Research & Health Center, IncHialeahFlorida33012-
K2 MEDICAL Research THE VILLAGESLady LakeFlorida32159-
ClinCloudMaitlandFlorida32751-
K2 Medical Research ORLANDOMaitlandFlorida32751-
ClinCloudMelbourneFlorida32940-
Merritt Island Medical Research, LLCMerritt IslandFlorida32952-
New Age Medical Research CorporationMiamiFlorida33186-
VIN-Andrew LermanMiamiFlorida33133-
Adult Medicine of Lake County, Inc.Mt. DoraFlorida32757-
Aqualane Clinical ResearchNaplesFlorida34105-
Suncoast Clinical Research, Inc.New Port RicheyFlorida34652-
Renstar Medical ResearchOcalaFlorida34470-
AdventHealth OrlandoOrlandoFlorida32804-
Charter Research - Winter ParkOrlandoFlorida32803-
Emerald Coast Neurology - Airport BoulevardPensacolaFlorida32504-
Progressive Medical ResearchPort OrangeFlorida32127-
Alzheimer's Research and Treatment CenterStuartFlorida34997-
Axiom Brain Health LLCTampaFlorida33609-
Care Access - TampaTampaFlorida33625-
Stedman Clinical TrialsTampaFlorida33613-
Charter Research - Lady LakeThe VillagesFlorida32162-
Alzheimer's Research and Treatment CenterWellingtonFlorida33414-
Palm Beach NeurologyWest Palm BeachFlorida33407-
Conquest ResearchWinter ParkFlorida32789-
Columbus Memory Center, LLCColumbusGeorgia31909-
Care Access - DecaturDecaturGeorgia30030-
Center for Advanced Research & EducationGainesvilleGeorgia30501-
North Georgia Clinical ResearchWoodstockGeorgia30189-
Northwest Clinical TrialsBoiseIdaho83704-
Care Access - Arlington HeightsArlington HeightsIllinois60005-
Great Lakes Clinical Trials - AndersonvilleChicagoIllinois60640-
Re:Cognition Health - ChicagoChicagoIllinois60611-
Alexian Brothers Medical CenterElk Grove VillageIllinois60007-
Care Access - South IndianapolisIndianapolisIndiana46227-
Josephson Wallack Munshower Neurology, PCIndianapolisIndiana46256-
Cedar Valley Medical SpecialistsWaterlooIowa50701-
Cotton O'Neil Clinical Research CenterTopekaKansas66606-
Care Access - Lake Charles (Bayou Pines)Lake CharlesLouisiana70601-
Tandem Clinical ResearchMarreroLouisiana70072-
Acadia HospitalBangorMaine04401-
Care Access - BaltimoreBaltimoreMaryland21213-
Adams Clinical BostonBostonMassachusetts02116-
Boston Clinical TrialsBostonMassachusetts02131-
Boston Center for MemoryNewtonMassachusetts02459-
Care Access - QuincyQuincyMassachusetts02169-
MedVadis Research CorporationWalthamMassachusetts02451-
Adams Clinical WatertownWatertownMassachusetts02472-
Revival Research Institute, LLCDearbornMichigan48126-
QUEST Research InstituteFarmington HillsMichigan48334-
HealthPartners Neuroscience CenterSaint PaulMinnesota55130-
Private Practice - Dr. Ronald Louis SchwartzHattiesburgMississippi39401-
Citizens Memorial Hospital DistrictBolivarMissouri65613-
Clinical Research ProfessionalsChesterfieldMissouri63005-
University Of Nebraska Medical CenterOmahaNebraska68198-
Vector Clinical TrialsLas VegasNevada89128-
Care Access - HobokenHobokenNew Jersey07030-
The Cognitive and Research Center of New Jersey - RidgewoodRidgewoodNew Jersey07450-
The Cognitive and Research Center of New JerseySpringfieldNew Jersey07081-
Advanced Memory Research Institute of New JerseyToms RiverNew Jersey08755-
IMA Clinical ResearchAlbuquerqueNew Mexico87109-
Care Access - CharlotteCharlotteNorth Carolina28210-
Medication ManagementGreensboroNorth Carolina27405-
Monroe Biomedical ResearchMonroeNorth Carolina28112-
Care Access - LimaLimaOhio45805-
North Star Medical ResearchMiddleburg HeightsOhio44130-
Summit HeadlandsPortlandOregon97210-
Clinical Research of PhiladelphiaPhiladelphiaPennsylvania19114-
Keystone Clinical StudiesPlymouth MeetingPennsylvania19462-
Rhode Island Mood & Memory Research InstituteEast ProvidenceRhode Island02914-
Butler HospitalProvidenceRhode Island02906-
Tribe Clinical Research, LLC- GreenvilleGreenvilleSouth Carolina29607-
Palmetto Clinical ResearchSummervilleSouth Carolina29485-
Neurology Clinic, P.C.CordovaTennessee38018-
Genesis Neuroscience ClinicKnoxvilleTennessee37909-
Senior Adults Specialty ResearchAustinTexas78757-
Gadolin ResearchBeaumontTexas77702-
Kerwin Medical CenterDallasTexas75231-
Kerwin Medical Center - Oak CliffDallasTexas75216-
Care Access - GeorgetownGeorgetownTexas78633-
Care Access - HoustonHoustonTexas77054-
Next Level Urgent CareHoustonTexas77057-
The University of Texas Health Science Center at HoustonHoustonTexas77054-
El Faro Health and TherapeuticsRio Grande CityTexas78582-
Central Texas Neurology Consultants, PARound RockTexas78681-
IMA Clinical Research San AntonioSan AntonioTexas78229-
Consano Clinical Research, LLCShavano ParkTexas78231-
Care Access - Arlington 2ArlingtonVirginia22206-
Re:Cognition HealthFairfaxVirginia22031-
Eastern Virginia Medical School (EVMS) Medical GroupNorfolkVirginia23510-
Northwest Clinical Research CenterBellevueWashington98007-
Rainier Clinical Research CenterRentonWashington98057-

Find similar trials in Birmingham, AL

By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
Parkway Medical Center· Birmingham, ALMD First Research - Chandler· Chandler, AZCare Access - 801 South Power Road, Mesa· Mesa, AZBanner Alzheimer's Institute· Phoenix, AZBanner Alzheimer's Institute Tucson· Tucson, AZNeuro-Pain Medical Center· Fresno, CA

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