A Trial of Casdozokitug in Combination With Toripalimab Plus Bevacizumab in Participants With Unresectable and/or Locally Advanced or Metastatic Hepatocellular Carcinoma

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
Coherus Oncology, Inc.
Study ID
NCT06679985
Phase
PHASE2
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Casdozokitug — DRUG
    Solution for infusion
  • Toripalimab — DRUG
    Solution for infusion
  • Bevacizumab — DRUG
    Solution for infusion

Study Details

The main goals of this study are to evaluate the safety and efficacy of casdozokitug in combination with toripalimab plus bevacizumab and to define a recommended dose for casdozokitug in combination with toripalimab plus bevacizumab.

Key Dates

First listed
Nov 8, 2024
Start date
Dec 20, 2024
Status verified
Apr 2026
Primary completion
Sep 30, 2027
Completion
Sep 30, 2027

Study Design

Enrollment
72 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm A: Casdozokitug Lower Dose + Toripalimab + Bevacizumab
  • Experimental: Arm B: Casdozokitug Higher dose + Toripalimab + Bevacizumab
  • Active Comparator: Arm C: Toripalimab + Bevacizumab

Primary Outcome Measure

Number of Participants with Treatment-emergent Adverse Events (TEAEs) [ Time Frame: From date of first dose to 90 days after date of last dose (Up to approximately 27 months) ]

Locations (25)

FacilityCityStateZIPSite coordinators
Mayo Clinic - ScottsdaleScottsdaleArizona85259-
University of Arizona - Cancer CenterTucsonArizona85719-
Beverly Hills Cancer CenterBeverly HillsCalifornia90211-
City of HopeDuarteCalifornia91010-
City of Hope at Irvine LennarIrvineCalifornia92618-
Cancer & Blood Specialty ClinicLakewoodCalifornia90712-
USC Norris Comprehensive Cancer CenterLos AngelesCalifornia90089-
Sarcoma Oncology CenterSanta MonicaCalifornia90403-
Mayo Clinic - JacksonvilleJacksonvilleFlorida32224-
The Winship Cancer Institute Emory UniversityAtlantaGeorgia30322-
Mountain States Tumor Institute at St. Luke's Regional Medical CenterBoiseIdaho83712-
University of Kansas Cancer CenterKansas CityKansas66160-
UofL Health Brown Cancer CenterLouisvilleKentucky40202-
University of Mississippi Medical CenterJacksonMississippi39216-
Christus St. Vincent Regional Medical CenterSanta FeNew Mexico87505-
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer CenterNew YorkNew York10021-
Montefiore Medical CenterThe BronxNew York10467-
University of North Carolina (UNC) - Chapel HillChapel HillNorth Carolina27599-
University Hospitals Cleveland Medical CenterClevelandOhio44106-
The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solovev Research Institute (OSUCCC - James)ColumbusOhio43210-
University of Pittsburgh Medical Center (UPMC) - Hillman Cancer CenterPittsburghPennsylvania15232-
Prisma Health Cancer InstituteGreenvilleSouth Carolina29605-
Virginia Cancer SpecialistsFairfaxVirginia22031-
Virginia Oncology AssociatesNorfolkVirginia23502-
UW Carbone Cancer Center - Cancer ConnectMadisonWisconsin53706-

Find similar trials in Scottsdale, AZ

By condition
Liver cancer
By specialty
OncologyGI oncologyHepatology
By research site
Mayo Clinic - Scottsdale· Scottsdale, AZUniversity of Arizona - Cancer Center· Tucson, AZBeverly Hills Cancer Center· Beverly Hills, CACity of Hope· Duarte, CACity of Hope at Irvine Lennar· Irvine, CACancer & Blood Specialty Clinic· Lakewood, CA

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