Hepatology Clinical Trials

Recruiting hepatology studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat hepatology. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting hepatology studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting hepatology trials

Within

Screening Cardiometabolic Opportunities Using Transformative Echocardiography Artificial Intelligence (SCOUT Echo-AI)

for MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease

6 sites incl. Los Angeles

Sponsor: Kaiser Permanente

Sex: All·Age: 18+

Code: NCT07216859

Liver Steatosis in Pediatric CD Patients

for Celiac Disease in Children

Sponsor: University of Palermo

Sex: All·Age: 1 - 14

Code: NCT06206616

Apply to this trial

SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease

for Non-Alcoholic Fatty Liver Disease

1 site in Chicago

Sponsor: Justin Ryder

Sex: All·Age: 12 - 20

Code: NCT03867487·Phase 2

TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE)

for Surgery

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 50 - 80

Code: NCT07653594

Development of a Risk Prediction Model for Immune-Targeted Therapy-Related Diarrhea in Patients With Hepatocellular Carcinoma Based on TCM Constitutional Types: A Prospective Cohort Study

for Liver Cancer

Sponsor: Affiliated Hospital of Chengde Medical University

Sex: All·Age: 18+

Code: NCT07741903

Human Models of Selective Insulin Resistance: Pancreatic Clamp

for Insulin Resistance

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65

Code: NCT06558422·Phase 1

Erlotinib for Hepatocellular Carcinoma Chemoprevention

for Cirrhosis, Liver

1 site in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT04172779·Phase 2

Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry

for Pancreas Cancer

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07732686

Hypothyroidism and Liver Fibrosis Severity in MASLD

for Metabolic Dysfunction-Associated Steatotic Liver Disease

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07793279

Microbiota trAnSplant ThERaPy In hEpatiC Encephalopathy (MASTERPIECE)

for Hepatic Encephalopathy

3 sites incl. West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 21+

Code: NCT07528690·Phase 2

Yttrium-90 Radiation Segmentectomy for Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 22+

Code: NCT07110233

Cemiplimab +/- Fianlimab Post Y90 Radioembolization in Patients With Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 site in Richmond

Sponsor: Virginia Commonwealth University

Sex: All·Age: 18+

Code: NCT07365839·Phase 1

Scheduled Meditation for Improving Postoperative Outcomes in Patients Undergoing Pancreatectomy

for Hepatocellular Carcinoma

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07608458

Prospective Evaluation of Hepatocellular Carcinoma Surveillance in At-Risk Patients (Screening HCC)

for Hepatocellular Carcinoma

Sponsor: D'Or Institute for Research and Education

Sex: All·Age: 18+

Code: NCT07764835

Patients With Hepatocellular Carcinoma (HCC)

for Hepatocellular Carcinoma

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07690683

Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer

for Bladder Cancer

3 sites incl. Boston

Sponsor: Lumina Pharmaceuticals Inc

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07781852·EARLY_Phase 1

Biomarker and Mechanism Study of Systemic Therapy in Unresectable HCC

for Hepatocellular Carcinoma

Sponsor: Shanghai Zhongshan Hospital

Sex: All·Age: 18+

Code: NCT07786792

A Randomized Controlled Trial Evaluating Different Doses of Oral Zinc Supplementation in Combination With Targeted Immunotherapy for Unresectable or Advanced Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sponsor: Anhui Provincial Hospital

Sex: All·Age: 18 - 75

Code: NCT07793695·Phase 2

A Prospective, Single-Arm, Open-Label Clinical Study of the Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy Combined With Targeted Therapy and a PD-1 Inhibitor in Patients With Postoperative Hepatocellular Carcinoma and Microvascular Invasion

for Liver Cancer

Sponsor: Zhai Wenlong

Sex: All·Age: 18 - 80

Code: NCT07790419·Phase 4

Evaluation of a Modified Bowel Preparation Regimen in Cirrhotic Patients Undergoing Colonoscopy

for Cirrhosis

Sponsor: Hospital do Divino Espírito Santo de Ponta Delgada

Sex: All·Age: 18+

Code: NCT07668778·Phase 3

Preoperative 3D Magnetic Resonance Elastography for Predicting Surgical Risk in Patients Undergoing Hepatectomy

for Hepatic Cancer

Sponsor: Second Affiliated Hospital of Xi'an Jiaotong University

Sex: All·Age: 18 - 80

Code: NCT07704203

YMN-136 Vaccine for Patients With Advanced Hepatobiliary and Pancreatic Malignancies

for Liver Cancer

Sponsor: West China Hospital

Sex: All·Age: 18 - 75

Code: NCT07763301·Phase 1

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A Study of TACE in Combination With SHR-8068, Adebrelimab, and Bevacizumab Versus TACE in Participants With Incurable Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sponsor: Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07691762·Phase 3

YMN-A02 for Advanced Primary Hepatocellular Carcinoma.

for Hepatocellular Carcinoma

Sponsor: West China Hospital

Sex: All·Age: 18 - 70

Code: NCT07580261·Phase 1

68Ga-SorB PET/CT Imaging in Patients With Solid Tumors

for Melanoma (Skin Cancer)

Sponsor: Peking University Third Hospital

Sex: All·Age: 18 - 75

Code: NCT07760012

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SL-28 for Advanced Solid Tumours

for Head & Neck Cancer

Sponsor: Second Life Therapeutics

Sex: All·Age: 18+

Code: NCT07341737·Phase 1, Phase 2

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GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular Cancer

for Pancreatic Cancer

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: 18 - 99

Code: NCT07627191·EARLY_Phase 1

Effect of Insulin Lowering on Lipogenesis

for Hyperinsulinemia

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65

Code: NCT07403604·Phase 1

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Molecular Characterization of Autoimmune Hepatitis: A Lipidomic Approach

for Autoimmune Hepatitis

Sponsor: Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis

Sex: All·Age: 18+

Code: NCT07644936

Development of a Predictive Score for the Risk of Infection in the Immediate Post-liver-transplant Period

for Cirrhosis

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18+

Code: NCT07647978

AI-Driven Tumor Response Evaluation for Solid Tumors

for Solid Tumor Cancer

Sponsor: Shanghai Zhongshan Hospital

Sex: All·Age: 18+

Code: NCT07685548

68Ga-PSMA-11 PET-directed Radioligand Therapy in Metastatic Hepatocellular Carcinoma (HCC)

for Liver Cancer

1 site in Cleveland

Sponsor: Melissa Lumish

Sex: All·Age: 18+

Code: NCT06852820·Phase 2

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HAIC-TACE Plus Apatinib and Camrelizumab for Liver Cancer

for Liver Cancer

Sponsor: Shanghai Zhongshan Hospital

Sex: All·Age: 18 - 80

Code: NCT07587034·Phase 1, Phase 2

68Ga-FAPI-PSMA PET Imaging for the Diagnosis of Solid Tumors

for Prostate Cancer

Sponsor: Peking University Cancer Hospital & Institute

Sex: All·Age: 18 - 75

Code: NCT07639801

CHARM Hepatocellular Carcinoma MEA Study

for HepatoCellular Carcinoma

Sponsor: AstraZeneca

Sex: All·Age: All ages

Code: NCT07650773

Impact of Propranolol on the Prognosis of Patients With Decompensated Cirrhosis and MELD Score > 9

for Cirrhosis

Sponsor: General Hospital of Shenyang Military Region

Sex: All·Age: 18+

Code: NCT07652203

Digitally Supported Prehabilitation Before Major Visceral Cancer Surgery

for Gastrointestinal Neoplasms

Sponsor: Ludwig Boltzmann Institute for Digital Health and Prevention

Sex: All·Age: 18+

Code: NCT07658313

Precision Navigation to Improve Community Cancer Screening Participation

for Cancer Screening

Sponsor: Hunan Cancer Hospital

Sex: All·Age: 45 - 74·Accepts healthy volunteers

Code: NCT07676383

HAIC + DEB-TACE + Toripalimab + Lenvatinib for Unresectable Intrahepatic Cholangiocarcinoma

for Liver Cancer

Sponsor: Shanghai Zhongshan Hospital

Sex: All·Age: 18 - 85

Code: NCT07685535·Phase 2

Yttrium-90 Carbon Microsphere Radioembolization in Previously Treated Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sponsor: Second Affiliated Hospital of Guangzhou Medical University

Sex: All·Age: 18+

Code: NCT07657273·Phase 2

Personalized Nutritional Intervention in Patients Undergoing TIPS Insertion for Refractory Ascites to Prevent Overt Hepatic Encephalopathy

for Cirrhosis

Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre

Sex: All·Age: 18 - 70

Code: NCT07634237

A First-in-Human Study of HH160 in Participants With Advanced or Metastatic Solid Tumors

for Solid Tumor

Sponsor: Huahui Health

Sex: All·Age: 18 - 75

Code: NCT07623369·Phase 1

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Bumetanide vs. Furosemide in Cirrhosis

for Cirrhosis

1 site in Salt Lake City

Sponsor: Stacy Johnson

Sex: All·Age: 18+

Code: NCT06941415·Phase 3

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4D-Flow MRI Assessment of Portal Hypertension and TIPS Outcomes in Cirrhosis

for Cirrhosis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07554183

Efficacy, Safety, and Tolerability of CS0159 Combined With Semaglutide in MAFLD Patients With Obesity and T2DM

for Type 2 Diabetes

Sponsor: Shanghai Jiao Tong University School of Medicine

Sex: All·Age: 18 - 65

Code: NCT07570810

China Metastatic Liver Cancer Clinical Registry Cohort Database

for Liver Metastases

Sponsor: Anhui Provincial Hospital

Sex: All·Age: 18 - 80

Code: NCT07602504

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Maintenance Zanzalintinib and Durvalumab in Participants With Advanced Hepatocellular Cancer

for Hepatocellular Carcinoma

1 site in Cleveland

Sponsor: Amit Mahipal

Sex: All·Age: 19+

Code: NCT07226063·Phase 2

AI-Based Multimodal Integration for Tumor Microenvironment Analysis and Response Prediction in HCC Treated With TACE Plus Immunotherapy and Targeted Therapy (CHANCE2601)

for Hepatocellular Carcinoma

Sponsor: Gao-jun Teng

Sex: All·Age: 18+

Code: NCT07584317

Phase Ia/Ib Study of FXB0871 Monotherapy in Locally Advanced/Metastatic Solid Tumors

for Solid Tumors

Sponsor: Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.

Sex: All·Age: 18+

Code: NCT07558200·Phase 1

HAIC vs. TACE Combined With Sintilimab and Bevacizumab for Intermediate HCC (Beyond Up-To-Seven)

for Hepatocellular Carcinoma

Sponsor: Binkui Li

Sex: All·Age: 18+

Code: NCT07594340·Phase 3

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Microplastics, Cirrhosis and Portal Hypertension

for Cirrhosis

Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Sex: All·Age: 18 - 70

Code: NCT07280390

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Low-Dose Bevacizumab and Atezolizumab Combined With TACE-HAIC in Unresectable Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sponsor: Third Affiliated Hospital, Sun Yat-Sen University

Sex: All·Age: 18+

Code: NCT07543510

Effect of Laparoscopic Splenectomy on Renal Function in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)

for Cirrhosis

Sponsor: Northern Jiangsu People's Hospital

Sex: All·Age: 18 - 80

Code: NCT07585773

Effect of LSD on Renal Function in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)

for Cirrhosis, Liver

Sponsor: Northern Jiangsu People's Hospital

Sex: All·Age: 18 - 80

Code: NCT07585786

Effect of LSD on Lipid Profiles in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)

for Cirrhosis, Liver

Sponsor: Northern Jiangsu People's Hospital

Sex: All·Age: 18 - 80

Code: NCT07588334

Effect of Laparoscopic Splenectomy on Lipid Profiles in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)

for Cirrhosis

Sponsor: Northern Jiangsu People's Hospital

Sex: All·Age: 18 - 80

Code: NCT07588373

Sequential FOLFOX-HAIC-TACE Plus Sintilimab-Bevacizumab Neoadjuvant Therapy Versus Direct Resection in Resectable High-Risk Recurrence Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sponsor: BinYong Liang

Sex: All·Age: 18 - 75

Code: NCT07522411·Phase 1, Phase 2

Outcomes After Liver and Biliary Resection at a High-Volume Center

for Liver Neoplasms

Sponsor: Azienda USL Toscana Centro

Sex: All·Age: 18+

Code: NCT07556835

PSYLIVER-PILOTE: Involvement of the Autonomic Nervous System in Hepatocellular Carcinoma (HCC)

for Hepato Cellular Carcinoma

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18+

Code: NCT07393074

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MONTEROSA - Italian Multicenter Observational Study to Evaluate Time to Clinical Hepatic Decompensation, Quality of Life, Effectiveness, and Safety of Tremelimumab Plus Durvalumab in Patients With Advanced or Unresectable Hepatocellular Carcinoma Who Have Received no Prior Systemic Treatment.

for Hepatocellular Carcinoma

Sponsor: AstraZeneca

Sex: All·Age: 18 - 100

Code: NCT07607769

Apply to this trial

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Hepatology clinical trials — common questions

Are hepatology clinical trials free to join?

Yes. Participating in a hepatology clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a hepatology clinical trial?

Each hepatology study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a hepatology trial near me?

Use the location controls above. We'll show recruiting hepatology trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many hepatology trials are recruiting right now?

We're currently tracking roughly 203 recruiting hepatology trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Hepatology trials by city

Boston, MA Los Angeles, CA Cleveland, OH Chicago, IL San Francisco, CA Birmingham, AL Orange, CA Duarte, CA Seattle, WA Ann Arbor, MI Aurora, CO Columbus, OH

Conditions in this area

Cirrhosis / liver disease Non-alcoholic fatty liver disease (NAFLD)Liver cancer