Liver cancer Clinical Trials

Recruiting liver cancer studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat liver cancer. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting liver cancer studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting liver cancer trials

Within

TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE)

for Surgery

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 50 - 80

Code: NCT07653594

Development of a Risk Prediction Model for Immune-Targeted Therapy-Related Diarrhea in Patients With Hepatocellular Carcinoma Based on TCM Constitutional Types: A Prospective Cohort Study

for Liver Cancer

Sponsor: Affiliated Hospital of Chengde Medical University

Sex: All·Age: 18+

Code: NCT07741903

Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry

for Pancreas Cancer

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07732686

Yttrium-90 Radiation Segmentectomy for Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 22+

Code: NCT07110233

Cemiplimab +/- Fianlimab Post Y90 Radioembolization in Patients With Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 site in Richmond

Sponsor: Virginia Commonwealth University

Sex: All·Age: 18+

Code: NCT07365839·Phase 1

Scheduled Meditation for Improving Postoperative Outcomes in Patients Undergoing Pancreatectomy

for Hepatocellular Carcinoma

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07608458

Prospective Evaluation of Hepatocellular Carcinoma Surveillance in At-Risk Patients (Screening HCC)

for Hepatocellular Carcinoma

Sponsor: D'Or Institute for Research and Education

Sex: All·Age: 18+

Code: NCT07764835

Patients With Hepatocellular Carcinoma (HCC)

for Hepatocellular Carcinoma

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07690683

Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer

for Bladder Cancer

3 sites incl. Boston

Sponsor: Lumina Pharmaceuticals Inc

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07781852·EARLY_Phase 1

Biomarker and Mechanism Study of Systemic Therapy in Unresectable HCC

for Hepatocellular Carcinoma

Sponsor: Shanghai Zhongshan Hospital

Sex: All·Age: 18+

Code: NCT07786792

A Randomized Controlled Trial Evaluating Different Doses of Oral Zinc Supplementation in Combination With Targeted Immunotherapy for Unresectable or Advanced Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sponsor: Anhui Provincial Hospital

Sex: All·Age: 18 - 75

Code: NCT07793695·Phase 2

A Prospective, Single-Arm, Open-Label Clinical Study of the Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy Combined With Targeted Therapy and a PD-1 Inhibitor in Patients With Postoperative Hepatocellular Carcinoma and Microvascular Invasion

for Liver Cancer

Sponsor: Zhai Wenlong

Sex: All·Age: 18 - 80

Code: NCT07790419·Phase 4

Preoperative 3D Magnetic Resonance Elastography for Predicting Surgical Risk in Patients Undergoing Hepatectomy

for Hepatic Cancer

Sponsor: Second Affiliated Hospital of Xi'an Jiaotong University

Sex: All·Age: 18 - 80

Code: NCT07704203

YMN-136 Vaccine for Patients With Advanced Hepatobiliary and Pancreatic Malignancies

for Liver Cancer

Sponsor: West China Hospital

Sex: All·Age: 18 - 75

Code: NCT07763301·Phase 1

Apply to this trial

A Study of TACE in Combination With SHR-8068, Adebrelimab, and Bevacizumab Versus TACE in Participants With Incurable Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sponsor: Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07691762·Phase 3

YMN-A02 for Advanced Primary Hepatocellular Carcinoma.

for Hepatocellular Carcinoma

Sponsor: West China Hospital

Sex: All·Age: 18 - 70

Code: NCT07580261·Phase 1

68Ga-SorB PET/CT Imaging in Patients With Solid Tumors

for Melanoma (Skin Cancer)

Sponsor: Peking University Third Hospital

Sex: All·Age: 18 - 75

Code: NCT07760012

Apply to this trial

CHARM Hepatocellular Carcinoma MEA Study

for HepatoCellular Carcinoma

Sponsor: AstraZeneca

Sex: All·Age: All ages

Code: NCT07650773

Apply to this trial

SL-28 for Advanced Solid Tumours

for Head & Neck Cancer

Sponsor: Second Life Therapeutics

Sex: All·Age: 18+

Code: NCT07341737·Phase 1, Phase 2

Apply to this trial

GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular Cancer

for Pancreatic Cancer

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: 18 - 99

Code: NCT07627191·EARLY_Phase 1

AI-Driven Tumor Response Evaluation for Solid Tumors

for Solid Tumor Cancer

Sponsor: Shanghai Zhongshan Hospital

Sex: All·Age: 18+

Code: NCT07685548

68Ga-PSMA-11 PET-directed Radioligand Therapy in Metastatic Hepatocellular Carcinoma (HCC)

for Liver Cancer

1 site in Cleveland

Sponsor: Melissa Lumish

Sex: All·Age: 18+

Code: NCT06852820·Phase 2

Apply to this trial

HAIC-TACE Plus Apatinib and Camrelizumab for Liver Cancer

for Liver Cancer

Sponsor: Shanghai Zhongshan Hospital

Sex: All·Age: 18 - 80

Code: NCT07587034·Phase 1, Phase 2

68Ga-FAPI-PSMA PET Imaging for the Diagnosis of Solid Tumors

for Prostate Cancer

Sponsor: Peking University Cancer Hospital & Institute

Sex: All·Age: 18 - 75

Code: NCT07639801

Digitally Supported Prehabilitation Before Major Visceral Cancer Surgery

for Gastrointestinal Neoplasms

Sponsor: Ludwig Boltzmann Institute for Digital Health and Prevention

Sex: All·Age: 18+

Code: NCT07658313

Precision Navigation to Improve Community Cancer Screening Participation

for Cancer Screening

Sponsor: Hunan Cancer Hospital

Sex: All·Age: 45 - 74·Accepts healthy volunteers

Code: NCT07676383

HAIC + DEB-TACE + Toripalimab + Lenvatinib for Unresectable Intrahepatic Cholangiocarcinoma

for Liver Cancer

Sponsor: Shanghai Zhongshan Hospital

Sex: All·Age: 18 - 85

Code: NCT07685535·Phase 2

Yttrium-90 Carbon Microsphere Radioembolization in Previously Treated Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sponsor: Second Affiliated Hospital of Guangzhou Medical University

Sex: All·Age: 18+

Code: NCT07657273·Phase 2

A First-in-Human Study of HH160 in Participants With Advanced or Metastatic Solid Tumors

for Solid Tumor

Sponsor: Huahui Health

Sex: All·Age: 18 - 75

Code: NCT07623369·Phase 1

Apply to this trial

China Metastatic Liver Cancer Clinical Registry Cohort Database

for Liver Metastases

Sponsor: Anhui Provincial Hospital

Sex: All·Age: 18 - 80

Code: NCT07602504

Apply to this trial

Maintenance Zanzalintinib and Durvalumab in Participants With Advanced Hepatocellular Cancer

for Hepatocellular Carcinoma

1 site in Cleveland

Sponsor: Amit Mahipal

Sex: All·Age: 19+

Code: NCT07226063·Phase 2

AI-Based Multimodal Integration for Tumor Microenvironment Analysis and Response Prediction in HCC Treated With TACE Plus Immunotherapy and Targeted Therapy (CHANCE2601)

for Hepatocellular Carcinoma

Sponsor: Gao-jun Teng

Sex: All·Age: 18+

Code: NCT07584317

Phase Ia/Ib Study of FXB0871 Monotherapy in Locally Advanced/Metastatic Solid Tumors

for Solid Tumors

Sponsor: Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.

Sex: All·Age: 18+

Code: NCT07558200·Phase 1

HAIC vs. TACE Combined With Sintilimab and Bevacizumab for Intermediate HCC (Beyond Up-To-Seven)

for Hepatocellular Carcinoma

Sponsor: Binkui Li

Sex: All·Age: 18+

Code: NCT07594340·Phase 3

Apply to this trial

Low-Dose Bevacizumab and Atezolizumab Combined With TACE-HAIC in Unresectable Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sponsor: Third Affiliated Hospital, Sun Yat-Sen University

Sex: All·Age: 18+

Code: NCT07543510

Sequential FOLFOX-HAIC-TACE Plus Sintilimab-Bevacizumab Neoadjuvant Therapy Versus Direct Resection in Resectable High-Risk Recurrence Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sponsor: BinYong Liang

Sex: All·Age: 18 - 75

Code: NCT07522411·Phase 1, Phase 2

Outcomes After Liver and Biliary Resection at a High-Volume Center

for Liver Neoplasms

Sponsor: Azienda USL Toscana Centro

Sex: All·Age: 18+

Code: NCT07556835

MONTEROSA - Italian Multicenter Observational Study to Evaluate Time to Clinical Hepatic Decompensation, Quality of Life, Effectiveness, and Safety of Tremelimumab Plus Durvalumab in Patients With Advanced or Unresectable Hepatocellular Carcinoma Who Have Received no Prior Systemic Treatment.

for Hepatocellular Carcinoma

Sponsor: AstraZeneca

Sex: All·Age: 18 - 100

Code: NCT07607769

Apply to this trial

Theranostic Approach by Early Multigene Sequencing in Advanced Poor Prognosis Cancers

for Breast Cancer

Sponsor: University Hospital, Lille

Sex: All·Age: 18+

Code: NCT06958224

MRG006A Combination Therapy for Advanced Hepatocellular Carcinoma (Phase I/II)

for Hepatocellular Carcinoma

Sponsor: Lepu Biopharma Co., Ltd.

Sex: All·Age: 18+

Code: NCT07479485·Phase 1, Phase 2

Apply to this trial

Targeting Ischemia-Induced Autophagy Dependence in Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 site in Philadelphia

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05842174·Phase 1, Phase 2

Apply to this trial

Cytokine Armored GPC3 Specific Chimeric Antigen Receptor Expressing T-cells in Adults With Solid Tumors

for Solid Tumor (Excluding CNS)

1 site in Seattle

Sponsor: Seattle Children's Hospital

Sex: All·Age: 21+

Code: NCT07224568·Phase 1

3D Liver Volumetry

for Liver Surgery

Sponsor: Medical University of Graz

Sex: All·Age: 18+

Code: NCT07297615

Clinical Trial of TB511 in Advanced Solid Tumors

for NSCLC

Sponsor: Twinpig Biolab, Inc.

Sex: All·Age: 19+

Code: NCT06400160·Phase 1, Phase 2

Efficacy and Safety of Pegylated Interferon Alpha-2β in Patients With Hepatitis B-related Hepatocellular Carcinoma After Radical Resection

for Hepatocellular Carcinoma

Sponsor: Ningbo No.2 Hospital

Sex: All·Age: 18 - 65

Code: NCT07553767·EARLY_Phase 1

Atezolizumab and Bevacizumab in Combination With Y^90 Radioembolization in HCC for Liver Transplant

for Hepatocellular Carcinoma

1 site in New York

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT07059494·Phase 4

Apply to this trial

Safety and Efficacy of Transarterial ICG Fluorescence-Guided Laparoscopic Anatomical Liver Resection

for Liver Cancer

Sponsor: West China Hospital

Sex: All·Age: 18 - 80

Code: NCT07295275

Apply to this trial

Distance-Based Exercise to Preserve Function and Prevent Disability

for Localized Malignant Solid Neoplasm

18 sites incl. Dublin

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07059884

Apply to this trial

Cancer Loyalty Card Study 2 (CLOCS-2)

for Pancreatic Cancer

Sponsor: Imperial College London

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06447064

Apply to this trial

Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid Tumors

for Cancer

Sponsor: Essen Biotech

Sex: All·Age: 8 - 85

Code: NCT07410494·Phase 1, Phase 2

Apply to this trial

Adjuvant TACE in HCC With High-risk Recurrence Factors

for Hepatocellular Carcinoma

Sponsor: Guangxi Medical University

Sex: All·Age: 18 - 70

Code: NCT07417397·Phase 3

Apply to this trial

Study of ACC-1898 in Adult Participants With Advanced Solid Tumors

for Hepatocellular Carcinoma

Sponsor: AccSalus Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT07252661·Phase 1

SARS-CoV-2 mRNA Vaccination in Patients With Hepatocellular Carcinoma Treated With Immune Checkpoint Inhibitors

for mRNA Vaccination

Sponsor: Medical University of Graz

Sex: All·Age: All ages

Code: NCT07341321

A Retrospective Study of Safety and Efficacy of Locoregional Therapies Combined With Anti-VEGF/TKIs and Immune Checkpoint Inhibitors for All Comers of Intention-to-treat Patients With Unresectable Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sponsor: Ningbo Medical Center Lihuili Hospital

Sex: All·Age: 16+

Code: NCT07368023

REGULUS: MRI-guided Adaptive SABR for Liver Cancers

for Liver Cancer

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07223307·Phase 2

Apply to this trial

First in Human Study of SIM0610 in Solid Tumors

for Advanced Solid Tumours

Sponsor: Jiangsu Simcere Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT07348211·Phase 1

Apply to this trial

Sintilimab Plus Bevacizumab Biosimilar as Neoadjuvant Therapy for Resectable Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sponsor: Sun Yat-sen University

Sex: All·Age: 18+

Code: NCT07324824·Phase 2

Apply to this trial

Nanocrystalline Megestrol Acetate for Cachectic Stage Locally Advanced Hepatocellular Carcinoma

for Cachexia

Sponsor: Changchun GeneScience Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 85

Code: NCT07356037·Phase 3

MR 7700 Multinuclear Application Clinical Study

for Hepatocellular Carcinoma

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07368049

Transarterial Chemoembolization With Low-Dose Bevacizumab Plus Atezolizumab as First-Line Treatment for Unresectable Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Sponsor: Third Affiliated Hospital, Sun Yat-Sen University

Sex: All·Age: 18 - 75

Code: NCT07281664

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Liver cancer clinical trials — common questions

Are liver cancer clinical trials free to join?

Yes. Participating in a liver cancer clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a liver cancer clinical trial?

Each liver cancer study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a liver cancer trial near me?

Use the location controls above. We'll show recruiting liver cancer trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many liver cancer trials are recruiting right now?

We're currently tracking roughly 116 recruiting liver cancer trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Liver cancer trials by city

Los Angeles, CA Cleveland, OH Orange, CA Birmingham, AL Duarte, CA San Francisco, CA Boston, MA Ann Arbor, MI Aurora, CO Chicago, IL Columbus, OH Jacksonville, FL

Related specialties

Oncology GI oncology Hepatology