Phase I/IIa Dose Finding Study of Triplet Regimen of Relatlimab Ipilimumab and NIvolumab in First Line Therapy of Metastatic Melanoma (TRINITY)

Part of paid clinical trials in Houston, Texas.

Sponsor
M.D. Anderson Cancer Center
Study ID
NCT06683755
Phase
PHASE1/PHASE2
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

To determine the recommended Phase IIa dose (RP2D) of the triplet combination. To determine the safety and efficacy of the combination at the RP2D.

Key Dates

First listed
Nov 12, 2024
Start date
Dec 31, 2024
Status verified
Aug 2026
Primary completion
Aug 16, 2030
Completion
Aug 16, 2032

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Phase I + IIa: Nivolumab + Relatlimab + Ipilimumab
    Participants particiapting on study will be randomized

Primary Outcome Measure

Safety and Adverse Events (AEs) [ Time Frame: Through study completion; an average of 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The University of Texas M. D. Anderson Cancer CenterHoustonTexas77030
Hussein Tawbi, MD,PHD
[email protected]
713-792-4185
Hussein Tawbi, MD,PHD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Houston, TX

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By condition
Melanoma
By specialty
OncologySkin cancerDermatology
By research site
The University of Texas M. D. Anderson Cancer Center· Houston, TX

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