Melanoma Clinical Trials

Recruiting melanoma studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat melanoma. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting melanoma studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting melanoma trials

Within

Aggressive Lipid Lowering Therapy in ICI-Treated Melanoma

for Melanoma

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 55+

Code: NCT07704918

A Study To Assess the Safety, and Tolerability of Nivolumab + Relatlimab Fixed-Dose Combination (FDC) In Untreated, Unresectable or Metastatic Melanoma Participants In India

for Untreated Melanoma

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 12+

Code: NCT07459543·Phase 4

Feasibility of an Enhanced Symptom Monitoring and Expedited Subspecialty Care Referral Intervention to Improve Side Effect Management for Patients With Melanoma Receiving an Immune Checkpoint Inhibitor

for Melanoma

1 site in Portland

Sponsor: OHSU Knight Cancer Institute

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07660666

Immune Checkpoint Inhibitor (ICI)-Drug-Drug Interaction (DDI) Study

for Gastrointestinal Neoplasms

1 site in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT07389525·EARLY_Phase 1

MELCHRONO: A Prospective Randomized Study Investigating Chrono-immunotherapy for Advanced Melanoma.

for Melanoma

Sponsor: Swiss Cancer Institute

Sex: All·Age: 18+

Code: NCT07574047·Phase 4

PROSECCO: A Phase 2, Single Arm, Neoadjuvant Study Evaluating Combination Cemiplimab, Fianlimab, And Ipilimumab In Patients With Surgically Resectable Melanoma

for Melanoma

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07511036·Phase 2

Dose Ranging, Toxicity Seeking, Phase 1 Trial of Oncolytic Adenoviral Therapy for Melanoma Intracranial and Extracranial Metastases

for Melanoma

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07444606·Phase 1

Dermoscopy Augmented Histology Trial, a Randomized Controlled Trial

for Melanoma

Sponsor: Herlev Hospital

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05004792

Timing of Immunotherapy in Melanoma

for Melanoma

Sponsor: Radboud University Medical Center

Sex: All·Age: 18+

Code: NCT07696715

Neoadjuvant Ipilimumab/Nivolumab for Patients With Recurrent, High Risk, Resectable Melanoma

for Melanoma

1 site in Salt Lake City

Sponsor: University of Utah

Sex: All·Age: 18+

Code: NCT06365619·Phase 2

Apply to this trial

Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis

for Metastatic Melanoma

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18+

Code: NCT07281924·Phase 1, Phase 2

Apply to this trial

Personalized Cancer Support (Thrive Track) to Manage the Emotional Needs of Young Adults With Thyroid, Melanoma and Testicular Cancer, PerCS-YA Trial

for Differentiated Thyroid Gland Carcinoma

1 site in Ann Arbor

Sponsor: University of Michigan Rogel Cancer Center

Sex: All·Age: 20 - 39

Code: NCT07529080

Clinical Genetics Branch Eligibility Screening Survey

for Melanoma

1 site in Rockville

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 - 99

Code: NCT07005297

Natural History Study of Early Life Exposures in Agriculture (ELEA)

for Prostate Cancer

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07328516

Impact of Dysport on PMFF Donor Scar

for Skin Cancer Excision Site

1 site in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07720726·Phase 4

A Study of HLX18 vs. OPDIVO® in Multiple Resected Solid Tumors

for Esophageal and/or Cardia Cancer

Sponsor: Shanghai Henlius Biotech

Sex: All·Age: 18 - 70

Code: NCT07518043·Phase 1

A Randomized, Double-Blind, Pharmacokinetic Similarity Study to Compare AVT32-DRL_PB With Keytruda® in Participants With Fully Resected Melanoma

for Melanoma

Sponsor: Alvotech Swiss AG

Sex: All·Age: 18+

Code: NCT07475572·Phase 1

Dietary Fiber to Induce Gut Microbiota-mediated Response to Immunotherapy in Melanoma.

for Melanoma (Skin) Stage IV

Sponsor: Radboud University Medical Center

Sex: All·Age: 18+

Code: NCT07686835·Phase 2

Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

for Advanced Biliary Tract Carcinoma

1 site in Portland

Sponsor: OHSU Knight Cancer Institute

Sex: All·Age: 18+

Code: NCT07405086·Phase 4

Apply to this trial

Pharmacokinetics, Safety, and Immunogenicity Comparison of Bmab1700 and Opdivo® as Adjuvant Monotherapy in Participants With Melanoma

for Melanoma

Sponsor: Biocon Biologics UK PLC

Sex: All·Age: 18+

Code: NCT07476326·Phase 1

Intratumoral N17350 in Advanced Solid Tumors

for Neoplasms, Solid Tumor

4 sites incl. Los Angeles

Sponsor: Onchilles Pharma Inc

Sex: All·Age: 18+

Code: NCT07339176·Phase 1, Phase 2

Apply to this trial

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

for Adenocarcinoma

1 site in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT07628634·EARLY_Phase 1

Apply to this trial

ctDNA-guided Addition of Ipilimumab to Patients Receiving Nivolumab and Relatlimab

for Metastatic Melanoma

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07504796·Phase 4

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Neoadjuvant SHR-1701 Plus Famitinib With Response-guided Adjuvant Therapy in Resectable Mucosal Melanoma

for Melanoma

Sponsor: Shanghai Zhongshan Hospital

Sex: All·Age: 18 - 75

Code: NCT07517653·Phase 2

Sub-topic Four: Clinical Translation of Original Radioactive Drugs for Precision Diagnosis and Treatment of Gastrointestinal Tumors -Clinical Application Value of PET Imaging Targeting LRRC15 in Malignant Tumors

for Pancreatic Cancer

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07552467

Apply to this trial

Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)

for Breast Cancer

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT07524114

Apply to this trial

Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization

for Melanoma

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT05264974·Phase 1

Apply to this trial

IL-17 Blockade to Decrease irAEs (REPLAY)

for Metastatic Melanoma

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07237594·Phase 1

Apply to this trial

A Study of DXC014 in Patients With Advanced Solid Tumors.

for Small Cell Lung Cancer

Sponsor: Hangzhou DAC Biotechnology Co., Ltd.

Sex: All·Age: 18+

Code: NCT07177937·Phase 1

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Influence of a High-fiber Diet on the Microbiota and the Response to Immunotherapy in Patients Treated for Melanoma.

for Melanoma

Sponsor: University Hospital, Grenoble

Sex: All·Age: 18+

Code: NCT07437300

A Study of BI 3810944 in Patients With Advanced Cancer

for Solid Tumours

4 sites incl. Louisville

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07224425·Phase 1

Apply to this trial

Study of ACC-1898 in Adult Participants With Advanced Solid Tumors

for Hepatocellular Carcinoma

Sponsor: AccSalus Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT07252661·Phase 1

Urolithin A in Patients With Previously Untreated Solid Tumors Receiving Immune Checkpoint Inhibitors

for Solid Cancer

Sponsor: Goethe University

Sex: All·Age: 18+

Code: NCT07161310

Apply to this trial

XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation

for Cancer

Sponsor: Xynomic Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05275374·Phase 1, Phase 2

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

for Amyloidosis

1 site in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07285044·Phase 2

Apply to this trial

Promoting Immunotherapy Efficacy With Low-Dose Liver RT

for Low-Dose Liver Radiation (LD-LRT)

1 site in Cincinnati

Sponsor: Jordan Kharofa

Sex: All·Age: 18+

Code: NCT07225036

Apply to this trial

A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3

for Melanoma

1 site in La Jolla

Sponsor: Replimune, Inc.

Sex: All·Age: 18+

Code: NCT06887348

Apply to this trial

Studying Quality of Life Inclusive of Mental Health and Cognitive Behavioral Therapy for Cancer Distress for the Improvement of Quality of Life in Stage III-IV Melanoma Patients

for Melanoma

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07379138

Apply to this trial

The Florida ASCENT Study

for Cancer

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 100

Code: NCT07042243

Apply to this trial

Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma

for Melanoma

1 site in Tampa

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 18+

Code: NCT06961357·Phase 1, Phase 2

Apply to this trial

DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.

for Haematological Malignancy

Sponsor: Cancer Research UK

Sex: All·Age: All ages

Code: NCT05770544·Phase 2, Phase 3

Apply to this trial

Physical Activity Directly Before Immunotherapy (Nivolumab and Ipilimumab) in Melanoma

for Metastatic Melanoma

Sponsor: Universitätsklinikum Hamburg-Eppendorf

Sex: All·Age: All ages

Code: NCT07564570

Apply to this trial

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

for Locally Advanced Alveolar Soft Part Sarcoma

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06066138·Phase 1

Apply to this trial

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

for Renal Cell Carcinoma

1 site in Pittsburgh

Sponsor: Diwakar Davar

Sex: All·Age: 18+

Code: NCT07223424·Phase 2

Apply to this trial

Testing the Effect of Sulforaphane, a Compound Naturally Found in Cruciferous Vegetables, on Preventing Melanoma in Patients With a Prior History of Melanoma

for Melanoma

1 site in Pittsburgh

Sponsor: Eastern Cooperative Oncology Group

Sex: All·Age: 18+

Code: NCT07040280·Phase 2

Evaluate the Safety and Efficacy of Autologous Tumor-infiltrating Lymphocyte in Patients With Refractory Melanoma Who Failed to Immune Checkpoint Inhibitors

for Melanoma

Sponsor: Samsung Medical Center

Sex: All·Age: 19 - 80

Code: NCT07028008

Mirdametinib in Patients With Advanced NF1-mutant Melanoma

for Advanced Unresectable Melanoma

1 site in San Francisco

Sponsor: Kevin Kim, MD

Sex: All·Age: 18+

Code: NCT07237100·Phase 2

Apply to this trial

Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

for Metastatic Malignant Solid Neoplasm

3 sites incl. Duarte

Sponsor: Anusha Kalbasi

Sex: All·Age: 18 - 75

Code: NCT04119024·Phase 1

Apply to this trial

A Study to Evaluate Adze1.C in Participants With Metastatic Melanoma

for Metastatic Melanoma

Sponsor: Adze Biotechnology Australia Pty Ltd

Sex: All·Age: 18+

Code: NCT07086105·Phase 1

Apply to this trial

A Phase I Clinical Study to Evaluate the PK Profile, Efficacy, Safety and Immunogenicity of HLX17 vs. Keytruda® in Multiple Resected Solid Tumors

for Non-small Cell Lung Cancer

12 sites incl. Glendale

Sponsor: Shanghai Henlius Biotech

Sex: All·Age: 18 - 85

Code: NCT07160335·Phase 1

Apply to this trial

VSV-02 Compassionate Use in Advanced Solid Tumors

for Advanced Solid Tumor

Sponsor: The First Affiliated Hospital of Xinxiang Medical College

Sex: All·Age: 18+

Code: NCT07260591·Phase 1

Apply to this trial

DESTINY-PANTUMOUR04

for Adenocarcinoma (NOS)

18 sites incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT07124000

Apply to this trial

Contrast-enhanced Ultrasound for Sentinel Node Detection

for Melanoma

Sponsor: The Netherlands Cancer Institute

Sex: All·Age: 18+

Code: NCT07310758·Phase 2, Phase 3

Apply to this trial

Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

for Melanoma

2 sites incl. Tucson

Sponsor: University of Arizona

Sex: All·Age: 18 - 99

Code: NCT06814496·Phase 1, Phase 2

Apply to this trial

A Study of GV20-0251 in Advanced or Refractory Solid Tumors

for HCC - Hepatocellular Carcinoma

Sponsor: West China Hospital

Sex: All·Age: 18+

Code: NCT07106827·Phase 1

Apply to this trial

NG2 and DLL3 CAR-T Cells Targeting Melanoma

for Melanoma

Sponsor: Shenzhen Geno-Immune Medical Institute

Sex: All·Age: 18 - 75

Code: NCT07193966·Phase 1, Phase 2

Apply to this trial

Combination Immunotherapy Targeting Melanoma

for Melanoma

Sponsor: Shenzhen Geno-Immune Medical Institute

Sex: All·Age: 18 - 75

Code: NCT06739226·Phase 1, Phase 2

Apply to this trial

IDOV-Immune for Advanced Solid Tumors

for Colorectal Cancer

3 sites incl. St Louis

Sponsor: ViroMissile, Inc.

Sex: All·Age: 18+

Code: NCT06910657·Phase 1

Apply to this trial

Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases

for Melanoma

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT06712927·Phase 2

Apply to this trial

MELAFERT: Impact of Adjuvant Therapy on FERTility in Patients With Resected MELAnoma at High Risk of Relapse.

for Melanoma

Sponsor: Intergruppo Melanoma Italiano

Sex: Female·Age: Up to 40

Code: NCT07092670

Apply to this trial

Melanoma clinical trials — common questions

Are melanoma clinical trials free to join?

Yes. Participating in a melanoma clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a melanoma clinical trial?

Each melanoma study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a melanoma trial near me?

Use the location controls above. We'll show recruiting melanoma trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many melanoma trials are recruiting right now?

We're currently tracking roughly 144 recruiting melanoma trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Melanoma trials by city

Los Angeles, CA Birmingham, AL Boston, MA Duarte, CA Orange, CA San Francisco, CA Tampa, FL Aurora, CO Columbus, OH Jacksonville, FL Madison, WI Portland, OR

Related specialties

Oncology Skin cancer Dermatology