Skin cancer Clinical Trials

Recruiting skin cancer studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat skin cancer. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting skin cancer studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting skin cancer trials

Within

A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck

for Squamous Cell Carcinoma

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07346196·Phase 2

Phase 1 Study Of TROP2 CAR/IL-15 TGFBR2 KO NK Cell In Patients With Oral Premalignant Lesions

for Squamous Cell Carcinoma

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07631013·Phase 1

Aggressive Lipid Lowering Therapy in ICI-Treated Melanoma

for Melanoma

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 55+

Code: NCT07704918

A Study To Assess the Safety, and Tolerability of Nivolumab + Relatlimab Fixed-Dose Combination (FDC) In Untreated, Unresectable or Metastatic Melanoma Participants In India

for Untreated Melanoma

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 12+

Code: NCT07459543·Phase 4

Feasibility of an Enhanced Symptom Monitoring and Expedited Subspecialty Care Referral Intervention to Improve Side Effect Management for Patients With Melanoma Receiving an Immune Checkpoint Inhibitor

for Melanoma

1 site in Portland

Sponsor: OHSU Knight Cancer Institute

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07660666

Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

for Squamous Cell Carcinoma

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07513389·Phase 2

Apply to this trial

Immune Checkpoint Inhibitor (ICI)-Drug-Drug Interaction (DDI) Study

for Gastrointestinal Neoplasms

1 site in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT07389525·EARLY_Phase 1

MELCHRONO: A Prospective Randomized Study Investigating Chrono-immunotherapy for Advanced Melanoma.

for Melanoma

Sponsor: Swiss Cancer Institute

Sex: All·Age: 18+

Code: NCT07574047·Phase 4

PROSECCO: A Phase 2, Single Arm, Neoadjuvant Study Evaluating Combination Cemiplimab, Fianlimab, And Ipilimumab In Patients With Surgically Resectable Melanoma

for Melanoma

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07511036·Phase 2

Dose Ranging, Toxicity Seeking, Phase 1 Trial of Oncolytic Adenoviral Therapy for Melanoma Intracranial and Extracranial Metastases

for Melanoma

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07444606·Phase 1

Combining Neo-adjuvant ATR-inhibition With Nodal SBRT for Early-stage Resectable HPV+ OPSCCs

for HPV Positive Oropharyngeal Squamous Cell Carcinoma

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT07578467·Phase 1, Phase 2

Dermoscopy Augmented Histology Trial, a Randomized Controlled Trial

for Melanoma

Sponsor: Herlev Hospital

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05004792

Timing of Immunotherapy in Melanoma

for Melanoma

Sponsor: Radboud University Medical Center

Sex: All·Age: 18+

Code: NCT07696715

Neoadjuvant Ipilimumab/Nivolumab for Patients With Recurrent, High Risk, Resectable Melanoma

for Melanoma

1 site in Salt Lake City

Sponsor: University of Utah

Sex: All·Age: 18+

Code: NCT06365619·Phase 2

Apply to this trial

Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis

for Metastatic Melanoma

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18+

Code: NCT07281924·Phase 1, Phase 2

Apply to this trial

Cosibelimab for CSCC in Patients With Kidney Transplant or Hematologic Malignancy

for Cutaneous Squamous Cell Carcinoma

2 sites in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07426484·Phase 4

Personalized Cancer Support (Thrive Track) to Manage the Emotional Needs of Young Adults With Thyroid, Melanoma and Testicular Cancer, PerCS-YA Trial

for Differentiated Thyroid Gland Carcinoma

1 site in Ann Arbor

Sponsor: University of Michigan Rogel Cancer Center

Sex: All·Age: 20 - 39

Code: NCT07529080

Clinical Genetics Branch Eligibility Screening Survey

for Melanoma

1 site in Rockville

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 - 99

Code: NCT07005297

Natural History Study of Early Life Exposures in Agriculture (ELEA)

for Prostate Cancer

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07328516

Impact of Dysport on PMFF Donor Scar

for Skin Cancer Excision Site

1 site in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07720726·Phase 4

A Study of HLX18 vs. OPDIVO® in Multiple Resected Solid Tumors

for Esophageal and/or Cardia Cancer

Sponsor: Shanghai Henlius Biotech

Sex: All·Age: 18 - 70

Code: NCT07518043·Phase 1

A Study of IDP-001 in Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

1 site in Edison

Sponsor: InduPro, Inc.

Sex: All·Age: 18+

Code: NCT07602842·Phase 1, Phase 2

A Randomized, Double-Blind, Pharmacokinetic Similarity Study to Compare AVT32-DRL_PB With Keytruda® in Participants With Fully Resected Melanoma

for Melanoma

Sponsor: Alvotech Swiss AG

Sex: All·Age: 18+

Code: NCT07475572·Phase 1

Developing and Testing the Effectiveness of a Skin Cancer Self-Detection Educational Program

for Skin Cancer

Sponsor: National University Hospital, Singapore

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07247123

Apply to this trial

Dietary Fiber to Induce Gut Microbiota-mediated Response to Immunotherapy in Melanoma.

for Melanoma (Skin) Stage IV

Sponsor: Radboud University Medical Center

Sex: All·Age: 18+

Code: NCT07686835·Phase 2

Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

for Advanced Biliary Tract Carcinoma

1 site in Portland

Sponsor: OHSU Knight Cancer Institute

Sex: All·Age: 18+

Code: NCT07405086·Phase 4

Apply to this trial

Pharmacokinetics, Safety, and Immunogenicity Comparison of Bmab1700 and Opdivo® as Adjuvant Monotherapy in Participants With Melanoma

for Melanoma

Sponsor: Biocon Biologics UK PLC

Sex: All·Age: 18+

Code: NCT07476326·Phase 1

AI-Assisted Endoscopy for Upper Aerodigestive Tract Lesions

for Upper Aerodigestive Tract Neoplasms

Sponsor: Istituto Italiano di Tecnologia

Sex: All·Age: 18+

Code: NCT07596355

Intratumoral N17350 in Advanced Solid Tumors

for Neoplasms, Solid Tumor

4 sites incl. Los Angeles

Sponsor: Onchilles Pharma Inc

Sex: All·Age: 18+

Code: NCT07339176·Phase 1, Phase 2

Apply to this trial

CARES : Customized Aftercare Report for Evaluated Skin Cancer Patients

for Management

Sponsor: Universitaire Ziekenhuizen KU Leuven

Sex: All·Age: 18 - 80

Code: NCT07330323

Apply to this trial

A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients

for Skin Cancer

2 sites in Pittsburgh

Sponsor: Marissa Lobl

Sex: All·Age: 18+

Code: NCT07286318·EARLY_Phase 1

Apply to this trial

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

for Adenocarcinoma

1 site in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT07628634·EARLY_Phase 1

Apply to this trial

Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer

for Squamous Cell Carcinoma

Sponsor: National Cancer Institute, Egypt

Sex: All·Age: 18+

Code: NCT07361133·Phase 2

ctDNA-guided Addition of Ipilimumab to Patients Receiving Nivolumab and Relatlimab

for Metastatic Melanoma

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07504796·Phase 4

Apply to this trial

Neoadjuvant SHR-1701 Plus Famitinib With Response-guided Adjuvant Therapy in Resectable Mucosal Melanoma

for Melanoma

Sponsor: Shanghai Zhongshan Hospital

Sex: All·Age: 18 - 75

Code: NCT07517653·Phase 2

Sub-topic Four: Clinical Translation of Original Radioactive Drugs for Precision Diagnosis and Treatment of Gastrointestinal Tumors -Clinical Application Value of PET Imaging Targeting LRRC15 in Malignant Tumors

for Pancreatic Cancer

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07552467

Apply to this trial

Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)

for Breast Cancer

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT07524114

Apply to this trial

Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization

for Melanoma

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT05264974·Phase 1

Apply to this trial

IL-17 Blockade to Decrease irAEs (REPLAY)

for Metastatic Melanoma

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07237594·Phase 1

Apply to this trial

PDT For Induction Therapy For Head And Neck Cancer

for Squamous Cell Carcinoma

2 sites in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07214987·Phase 2

Apply to this trial

A Study of DXC014 in Patients With Advanced Solid Tumors.

for Small Cell Lung Cancer

Sponsor: Hangzhou DAC Biotechnology Co., Ltd.

Sex: All·Age: 18+

Code: NCT07177937·Phase 1

Apply to this trial

Vitamin D Effects on Immune Microenvironment of Nonmelanoma Skin Cancer After Photodynamic Therapy (PDT)

for Nonmelanoma Skin Cancer

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07241585

Apply to this trial

Influence of a High-fiber Diet on the Microbiota and the Response to Immunotherapy in Patients Treated for Melanoma.

for Melanoma

Sponsor: University Hospital, Grenoble

Sex: All·Age: 18+

Code: NCT07437300

A Study of BI 3810944 in Patients With Advanced Cancer

for Solid Tumours

4 sites incl. Louisville

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07224425·Phase 1

Apply to this trial

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

for Head and Neck Cancer

1 site in Baltimore

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18+

Code: NCT07209189·Phase 2

Apply to this trial

TIL Therapy in cSCC and MCC

for Cutaneous Squamous Cell Carcinoma

1 site in Boston

Sponsor: Karam Khaddour, MD, MS

Sex: All·Age: 18+

Code: NCT07288073·Phase 2

Apply to this trial

Early Detection of Skin Tumors Using a Telemedicine Tool in Primary Care

for Skin Cancer Prevention

Sponsor: Institute of Health Information and Statistics of the Czech Republic

Sex: All·Age: 50+

Code: NCT07349940

Apply to this trial

Study of ACC-1898 in Adult Participants With Advanced Solid Tumors

for Hepatocellular Carcinoma

Sponsor: AccSalus Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT07252661·Phase 1

Urolithin A in Patients With Previously Untreated Solid Tumors Receiving Immune Checkpoint Inhibitors

for Solid Cancer

Sponsor: Goethe University

Sex: All·Age: 18+

Code: NCT07161310

Apply to this trial

Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous SCC for Immunocompromised Patients

for Squamous Cell Carcinoma

10 sites incl. Gilbert

Sponsor: Alpha Tau Medical LTD.

Sex: All·Age: 18+

Code: NCT06615635

Apply to this trial

XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation

for Cancer

Sponsor: Xynomic Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05275374·Phase 1, Phase 2

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

for Amyloidosis

1 site in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07285044·Phase 2

Apply to this trial

Promoting Immunotherapy Efficacy With Low-Dose Liver RT

for Low-Dose Liver Radiation (LD-LRT)

1 site in Cincinnati

Sponsor: Jordan Kharofa

Sex: All·Age: 18+

Code: NCT07225036

Apply to this trial

A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3

for Melanoma

1 site in La Jolla

Sponsor: Replimune, Inc.

Sex: All·Age: 18+

Code: NCT06887348

Apply to this trial

Studying Quality of Life Inclusive of Mental Health and Cognitive Behavioral Therapy for Cancer Distress for the Improvement of Quality of Life in Stage III-IV Melanoma Patients

for Melanoma

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07379138

Apply to this trial

The Florida ASCENT Study

for Cancer

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 100

Code: NCT07042243

Apply to this trial

Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma

for Melanoma

1 site in Tampa

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 18+

Code: NCT06961357·Phase 1, Phase 2

Apply to this trial

Optical Characterization and Multi-modality, Multi-scale Modeling of Human Skin Applied to Cancer Diagnosis.

for Skin Cancer

Sponsor: Centre Hospitalier Régional Metz-Thionville

Sex: All·Age: 18+

Code: NCT07406022

Apply to this trial

DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.

for Haematological Malignancy

Sponsor: Cancer Research UK

Sex: All·Age: All ages

Code: NCT05770544·Phase 2, Phase 3

Apply to this trial

Physical Activity Directly Before Immunotherapy (Nivolumab and Ipilimumab) in Melanoma

for Metastatic Melanoma

Sponsor: Universitätsklinikum Hamburg-Eppendorf

Sex: All·Age: All ages

Code: NCT07564570

Apply to this trial

Skin cancer clinical trials — common questions

Are skin cancer clinical trials free to join?

Yes. Participating in a skin cancer clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a skin cancer clinical trial?

Each skin cancer study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a skin cancer trial near me?

Use the location controls above. We'll show recruiting skin cancer trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many skin cancer trials are recruiting right now?

We're currently tracking roughly 198 recruiting skin cancer trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Skin cancer trials by city

Boston, MA Los Angeles, CA Birmingham, AL San Francisco, CA Tampa, FL Duarte, CA Orange, CA Aurora, CO Columbus, OH Jacksonville, FL Madison, WI Portland, OR

Conditions in this area

Melanoma Skin cancer