A Research Study on How NNC0487-0111, a New Medicine, Works in Chinese Participants After 10 Days of Oral Dosing

Sponsor
Novo Nordisk A/S
Study ID
NCT06820476
Phase
PHASE1
Status
Completed

Conditions

Eligibility Criteria

Sex
MALE
Age
18 Years - 55 Years
Healthy Volunteers
Not accepted

Interventions

  • NNC0487-0111 — DRUG
    Participants will be randomized to receive NNC0487-0111 tablet orally at dose levels 1, 2, or 3.
  • Placebo (NNC0487-0111) — DRUG
    Participants will be randomized to receive a placebo tablet orally matched to NNC0487-0111.

Study Details

The study is testing a new study medicine called NNC0487-0111 for weight control in Chinese people with Body mass index (BMI) greater than or equal to (\>=) 24 kilogram per square meter (kg/m\^2). The aim of this study is to find out how safe the study medicine is and how it behaves in your body. Participants will either get NNC0487-0111 or placebo. Which treatment participants will get is decided by chance. Oral NNC0487-0111 is a new medicine which cannot be prescribed by doctors but has previously been tested in humans. The study will last for about 60 days.

Key Dates

Start date
Feb 9, 2025
Status verified
Aug 2025
Primary completion
May 14, 2025
Completion
May 14, 2025

Study Design

Enrollment
29 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: NNC0487-0111 (dose 1)
    Participants will be randomized to receive a single dose of NNC0487-0111.
  • Experimental: NNC0487-0111 (dose 2)
    Participants will be randomized to receive a single dose of NNC0487-0111.
  • Experimental: NNC0487-0111 (dose 3)
    Participants will be randomized to receive a single dose of NNC0487-0111.
  • Placebo Comparator: Placebo
    Participants will be randomized to receive matching Placebo to NNC0487-0111.

Primary Outcome Measure

Number of treatment emergent adverse events (TEAEs) [ Time Frame: From first NNC0487-0111 administration (Day 1) to completion of the end-of-study visit (Day 31) ]

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