Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT06911229
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Deep Brain Stimulation (DBS) — DEVICE
    Patients will receive DBS in the clinically-optimized setting.

Study Details

Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

Key Dates

First listed
Apr 4, 2025
Start date
Oct 1, 2025
Status verified
Aug 2025
Primary completion
Jul 31, 2027
Completion
Jul 31, 2027

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: DBS ON
    DBS will be turned on
  • No Intervention: DBS OFF
    DBS will be turned off

Primary Outcome Measure

Step length rate of adaptation [ Time Frame: 1 hour ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of FloridaGainesvilleFlorida32611
Julia Choi

Find similar trials in Gainesville, FL

By condition
Parkinson's disease
By specialty
NeurologyBrain disorders
By research site
University of Florida· Gainesville, FL

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