A Comparative Evaluation of Different Histopathological Indices of Mucosal Healing in Ulcerative Colitis

Sponsor
Assiut University
Study ID
NCT06918093
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Study Details

* To evaluate the histological activity and the presence of specific histopathologic features at diagnosis in ulcerative colitis patients before and after receiving treatment using the three most widely- used histological scoring indices (Gobeos score , Robarts Histopathologic Index and Nancy Index ) * To compare the findings of the three histopathological indices with each other as a trial to select the best, reproducible, easily and consistently applied system that could be adopted in routine pathological evaluation. Moreover, an attempt to introduce a novel customized method of histopathological evaluation could be carried out. * To correlate the clinical and endoscopic follow up data of patient on treatment with the histopathological evaluation. This will be done in order to evaluate the possible predictive effect of histopathological evaluation on the disease course and hence as a tool to drive possible modification of the therapeutic choices

Key Dates

First listed
Apr 9, 2025
Start date
Jun 30, 2025
Status verified
Apr 2025
Primary completion
Sep 30, 2026
Completion
Oct 31, 2027

Study Design

Enrollment
60 participants (estimated)

Primary Outcome Measure

A Comparative Evaluation of Different Histopathological Indices of Mucosal Healing in Ulcerative Colitis, and their Correlation with Clinical Follow-up Data [ Time Frame: 4 months ]

Central Contacts

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